Autoantibodies to neurotypic and gliotypic proteins as biomarkers of neurotoxicity: Assessment of trimethyltin (TMT)

NeuroToxicology

Volumn 29, Issue 1, 2008, Pages 109-115

  El Fawal, Hassan A N ^a   O'Callaghan, James P ^b  

^a MERCY COLLEGE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Autoantibodies; Biomarkers; GFAP; Myelin basic protein; Nervous system proteins; Neurofilament; Neurotoxicity; Trimethyltin

Indexed keywords

AUTOANTIBODY; BIOLOGICAL MARKER; BRAIN ANTIBODY; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; MYELIN BASIC PROTEIN; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN 160; NEUROFILAMENT PROTEIN 200; NEUROFILAMENT PROTEIN 68; SODIUM CHLORIDE; TRIMETHYLTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BLOOD SAMPLING; BRAIN SLICE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; MALE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AUTOANTIBODIES; BIOLOGICAL MARKERS; BRAIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MYELIN BASIC PROTEINS; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; RATS; RATS, LONG-EVANS; TIME FACTORS; TRIMETHYLTIN COMPOUNDS;

ANIMALIA; RATTUS;

EID: 37849022444     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2007.09.009     Document Type: Article

References (40)

1. Abbas A.K., Lichtman A.H., and Pober J.S. B cell activation and antibody production. Cellular and molecular immunology. fourth ed. (2000), WB Saunders, New York pp. 182-207
2. Balaban C.D., O'Callaghan J.P., and Billingsley M.L. Trimethyltin-induced neuronal damage in the rat brain: comparative studies using silver degeneration stains, immunocytochemistry and immunoassay for neuronotypic and gliotypic proteins. Neurosci 26 (1988) 337-361
3. Block M.L., and Hong J. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76 (2005) 77-98
4. Bora N.S., Kim M.C., Kabeer N.H., Simpson S.C., Tandhasetti M.T., Cirrito T.P., et al. Experimental autoimmune anterior uveitis. Induction with melanin-associated antigen from the iris and ciliary body. Invest Ophthalmol Vis Sci 36 (1995) 1056-1066
5. Bouras C., Riederer B.M., Kovari E., Hof P.R., and Giannakopoulos P. Humoral immunity in brain aging and Alzheimer's disease. Brain Res. Rev 48 (2005) 477-487
6. Brock T.O., and O'Callaghan J.P. Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocyte-specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system. J Neurosci 7 (1987) 931-942
7. Chang L.W. Toxico-neurology and neuropathology induced by metals. In: Chang L.W. (Ed). Toxicology of metals (1996), CRC Press, Inc., Boca Raton 511-536
8. de Vos A.F., van Meurs M., Brok M.H., Boven L.A., Hintzen R.Q., van der Valk P., et al. Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J Immunol 169 (2002) 5415-5423
9. El-Fawal H.A.N. Concepts of immunological markers of metal toxicity. In: Chang L. (Ed). Metal toxicity (1996), CRC Press, Boca Raton 857-865
10. El-Fawal H.A.N., Gong Z.L., Little A.R., and Evans H.L. Exposure to methyl mercury results in serum autoantibodies to neurotypic and gliotypic proteins. NeuroToxicol 17 (1996) 531-540
11. El-Fawal H.A.N., Waterman S.J., De Feo A., and Shamy M.Y. Neuroimmunotoxicology: humoral assessment of neurotoxicity and autoimmune mechanisms. Environ Health Perspect 107 Supl 5 (1999) 680-775
12. Fichorova R., Mavrov C., Mladenov I., Dimitrova E., and Nakov L. A novel approach to the generation of antibodies against phylogenetically preserved sperm antigens. Theriogenol 45 (1996) 957-975
13. Frank R.A., Galasko D., Hampel H., Hardy J., de Leon M.J., Mehta P.D., et al. Biological markers for therapeutic trials in Alzheimer's disease. Neurobiol Aging 24 (2003) 521-536
14. Garman R.H., Fix A.S., Jortner B.S., Jensen K.F., Hardisty J.F., Claudio L., et al. Methods to identify and characterize developmental neurotoxicity for human health risk assessment. II: neuropathology. Environ Health Perspect 109 Suppl. 1 (2001) 93-100
15. Kawano K., Hirashima T., Mori S., Saitoh Y., Kurosumi M., and Natori T. New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia. Diabetes 40 (1999) 1375-1381
16. Kindt T.J., Goldsby R.A., and Osborne B.A. B-cell generation, activation and differentiation. Kuby immunology. sixth ed. (2007), WH Freeman, New York pp: 271-301
17. Little A.R., Benkovic S.A., Miller D.B., and O'Callaghan J.P. Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines. Neurosci 115 (2002) 307-320
18. Miller D.B., and O'Callaghan J.P. Biochemical, functional and morphological indicators of neurotoxicity: effects of acute administration of trimethyltin to the developing rat. J Pharmacol Exp Ther 231 (1964) 744-751
19. Nieborj-Dobosz I., Dziewulska D., and Janik P. Auto-antibodies against proteins of spinal cord cells in cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS). Folia Neuropathol 44 (2006) 191-196
20. O'Callaghan J.P. Neurotypic and gliotypic proteins as biochemical markers of neurotoxicity. Neurotoxicol Teratol 10 (1988) 445-452
21. O'Callaghan J.P. Quantification of glial fibrillary acidic protein: comparison of slot-immunobinding assays with a novel sandwich ELISA. Neurotoxicol Teratol 13 (1991) 275-281
22. O'Callaghan J.P. Measurement of glial fibrillary acidic protein. In: Costa L.G. (Ed). Current protocols in toxicology (2002), John Wiley and Sons, New York p.12.81.1-12.8.12
23. O'Callaghan J.P., and Miller D.B. Neuron-specific phosphoproteins as biochemical indicators of neurotoxicity: effects of acute administration of trimethyltin to the adult rat. J Pharmacol Exp Ther 231 (1984) 736-743
24. O'Callaghan J.P., Imai H., Miller D.B., and Minter A. Quantitative immunoblots of proteins resolved from brain homogenates: underestimation of specific protein concentration and of treatment effects. Anal Biochem 274 (1999) 18-26
25. O'Callaghan J.P., and Sriram K. Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity. Expert Opin Drug Safety 4 (2005) 433-442
26. Orr C.F., Rowe D.B., Mizuno Y., Mori H., and Halliday G.M. A possible role for humoral immunity in the pathogenesis of Parkinson's disease. Brain 128 (2005) 2665-2674
27. Pagani M.R., Reisin R.C., and Uchitel O.D. Calcium signaling pathways mediating synaptic potentiation triggered by amyotropic lateral sclerosis IgG in motor nerve terminals. J Neurosci 26 (2006) 2661-2672
28. Papachroni K.K., Ninkina N., Papapanagiotou A., Hadjigeorgiou J.M., Xiromerisiou G., Papadimitriou A., et al. Autoantibodies to alpha-synuclein in inherited Parkinson's disease. J Neurochem (2007) 749-756
29. Petricoin E.F., Belluco C., Araujo R.P., and Liotta L.A. The blood peptidome: a higher dimension of information content for cancer biomarker discovery. Nat Rev Cancer 6 (2006) 961-967
30. Poletaev A., and Osipenko L. General network of natural autoantibodies as immunological homunculus (Immunculus). Autoimmun Rev 2 (2003) 264-271
31. Poletaev A.B., Morozov S.G., Gnedenko B.B., Zlunikin V.M., and Korzhenevskey D.A. Serum anti-S100b, anti-GFAP and anti-NGF autoantibodies of IgG class in healthy persons and patients with mental and neurological disorders. Autoimmunity 32 (2000) 33-38
32. Poon H.F., Castegna A., Farr S.A., Thongboonkerd V., Lynn B.C., Banks W.A., et al. Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone eight mice brain. Neurosci 126 (2004) 915-926
33. Rowland L.P., and Shneider N.A. Amyotrophic lateral sclerosis. New Eng J Med 344 (2001) 1688-1700
34. Scott D., Smith K.E., O'Brien B.J., and Angelides K.J. Characterization of mammalian neurofilament triplet proteins. Subunit stoichiometry and morphology of native and reconstituted filaments. J Biol Chem 260 (1985) 10736-10747
35. Streit W.J., Mrak R.E., and Griffen W.S.T. Microglia and neuroinflammation: a pathological perspective. J Neuroinflamm 1 (2004) 14-18
36. Switzer R.C. Application of silver degeneration stains for neurotoxicity testing. Toxicol Pathol 28 (2000) 70-83
37. Targoni O.S., Baus J., Hofstetter H.H., Hesse M.D., Karulin A.Y., Boehm B.O., et al. Frequencies of neuroantigen-specific T cells in the central nervous system versus the immune periphery during the course of experimental allergic encephalomyelitis. J. Immunol 166 (2001) 4757-4764
38. Town T., Nikolic V., and Tan J. The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflamm 2 (2005) 24-34
39. Veronesi B., Pringle J., and Mezei C. Myelin basic protein-mRNA used to monitor trimethyltin neurotoxicity in rats. Toxicol Appl Pharmacol 108 (1991) 428-435
40. Yokoi T., Nagayama T.S., Kajiwara R., Kawaguchi Y., Aizawa T., Otaki Y., et al. Occurrence of autoimmune antibodies to liver microsomal proteins associated with lethal hepatitis in LEC rats: effects of TJN-101 ((+)-(6S,7S,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11-methylenedioxy-6-dibenzo[a,c]cyclooctenol) on the development of hepatitis and the autoantibodies. Toxicol Lett 76 (1995) 33-38