No association of migraine to the GABA-A receptor complex on chromosome 15

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 1, 2008, Pages 33-36

  Oswell, G ^a,b   Kaunisto, M A ^a,c   Kallela, M ^c   Hamalainen E ^a   Anttila, V ^a   Kaprio, J ^a,d   Farkkila M ^c   Wessman, M ^a,c   Palotie, A ^a,c,e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Association study; Gamma amino butyric acid (GABA) A; Migraine; Single nucleotide polymorphisms (SNP)

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A5 RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B3 RECEPTOR; 4 AMINOBUTYRIC ACID G RECEPTOR; 4 AMINOBUTYRIC ACID G3 RECEPTOR; DNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHROMOSOME 15; CHROMOSOME 15Q; CONTROLLED STUDY; FEMALE; GABAERGIC SYSTEM; GENE CLUSTER; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MIGRAINE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 15; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MIGRAINE WITH AURA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A; VARIATION (GENETICS);

EID: 37849015494     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30566     Document Type: Article

References (11)

1. Estevez M, Gardner KL. 2004. Update on the genetics of migraine. Hum Genet 114:225-235.
2. Kallela M, Wessman M, Färkkilä M. 2001. Validation of a migraine specific questionnaire for use in family studies. Eur J Neurol 8:61-66.
3. Kaunisto M, Kallela M, Hämäläinen E, Kilpikari R, Havanka H, Harno H, Nissilä M, Säkö E, Ilmavirta M, Liukkonen J, Teirmaa H, Törnwall O, Jussila M, Terwilliger J, Färkkilä M, Kaprio J, Palotie A, Wessman M. 2006. Testing of variants in the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association to migraine with aura. Cephalalgia 26(12):1462-1472.
4. Li J, Ji L. 2005. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95:221-227.
5. Netzer C, Freudenberg J, Toliat M, Heinze A, Heinze-Kuhn K, Thiele H, Goebel I, Nürnberg P, Ptáček LJ, Göbel H, Todt U, Kubisch C. 2007. Genetic association studies of the chromosome 15 GABA-A receptor cluster in migraine with aura. Am J Med Genet Part B (in press).
6. Nyholt DR. 2004. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765-769.
7. Russell MB, Olesen J. 1995. Increased familial risk and evidence of genetic factor in migraine. Brit Med J 311:541-544.
8. Russo L, Mariotti P, Sangiorgi E, Giordano T, Ricci I, Iupi F, Chiera R, Guzzetta F, Neri G, Gurrieri F. 2005. A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes. Am J Hum Genet 76:327-333.
9. Silander K, Axelsson T, Widen E, Dahlgren A, Palotie A, Syvänen AC. 2003. Analysis of genetic variation in the GenomEUtwin project. Twin Res 6:391-398.
10. The International Classification of Headache Disorders. 2nd edition. 2004. Cephalalgia 24 (Suppl 1):9-160.
11. Wessman M, Kallela M, Kaunisto MA, Marttila P, Sobel E, Hartial J, Oswell G, Leal SM, Papp JC, Hamalainen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor RM, Zwart JA, Ilmavirta M, Havanka H, Farkkila M, Peltonen L, Palotie A. 2002. A susceptibility locus for migraine with aura, on chromosome 4q24. Am J Hum Genet 70:652-662.