No association between common variants in glyoxalase 1 and autism spectrum disorders

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 1, 2008, Pages 124-127

  Rehnström, Karola ^a,b   Ylisaukko oja, Tero ^a,b   Vanhala, Raija ^c   Von Wendt, Lennart ^c   Peltonen, Leena ^a,b,d   Hovatta, Iiris ^a,b,e  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BIOMEDICUM HELSINKI   (Finland)

Author keywords

Asperger syndrome; Autism; Candidate gene study; Family based association; Glyoxalase 1

Indexed keywords

GLYOXALASE; HYDROXYACYLGLUTATHIONE HYDROLASE; LACTOYLGLUTATHIONE LYASE;

ARTICLE; ASPERGER SYNDROME; AUTISM; BRAIN TISSUE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME STRUCTURE; FINLAND; GENE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; GLO1 GENE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; AUTISTIC DISORDER; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LACTOYLGLUTATHIONE LYASE; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; VARIATION (GENETICS);

EID: 37849005694     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30582     Document Type: Article

References (23)

1. Auranen M, Vanhala R, Varilo T, Ayers K, Kempas E, Ylisaukko-Oja T, Sinsheimer JS, Peltonen L, Jarvela I. 2002. A genomewide screen for autism-spectrum disorders: Evidence for a major susceptibility locus on chromosome 3q25-27. Am J Hum Genet 71(4):777-790.
2. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M. 1995. Autism as a strongly genetic disorder: Evidence from a British twin study. Psychol Med 25(1):63-77.
3. Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, Charman T. 2006. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The Special Needs and Autism Project (SNAP). Lancet 368(9531):210-215.
4. Barrett JC, Fry B, Mailer J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-265.
5. Bolton P, Macdonald H, Pickles A, Rios P, Goode S, Crowson M, Bailey A, Rutter M. 1994. A case-control family history study of autism. J Child Psychol Psychiatry 35(5):877-900.
6. Chen F, Wollmer MA, Hoerndli F, Munch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Gotz J. 2004. Role for glyoxalase I in Alzheimer's disease. Proc Natl Acad Sci USA 101(20):7687-7692.
7. Fombonne E. 2005. Epidemiology of autistic disorder and other pervasive developmental disorders. J Clin Psychiatry 66 (Suppl 10):3-8.
8. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, et al. 2002. The structure of haplotype blocks in the human genome. Science 296(5576):2225-2229.
9. Goring HH, Terwilliger JD. 2000. Linkage analysis in the presence of errors IV: Joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. Am J Hum Genet 66(4):1310-1327.
10. Horvath S, Xu X, Laird NM. 2001. The family based association test method: Strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9(4):301-306.
11. Hovatta I, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, Schadt EE, Ellison JA, Verma IM, Lockhart DJ, et al. 2005. Glyoxalase 1 and glutathione reductase regulate anxiety in mice. Nature 438:662-666.
12. Jamain S, Quach H, Betancur C, Rastam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, et al. 2003. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet 34(1):27-29.
13. Junaid MA, Kowal D, Barua M, Pullarkat PS, Sklower Brooks S, Pullarkat RK. 2004. Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor. Am J Med Genet Part A 131(1):11-17.
14. Kromer SA, Kessler MS, Milfay D, Birg IN, Bunck M, Czibere L, Panhuysen M, Putz B, Deussing JM, Holsboer F, et al. 2005. Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety. J Neurosci 25(17):4375-4384.
15. Kuhla B, Boeck K, Luth HJ, Schmidt A, Weigle B, Schmitz M, Ogunlade V, Munch G, Arendt T. 2006. Age-dependent changes of glyoxalase I expression in human brain. Neurobiol Aging 27(6):815-822.
16. Laumonnier F, Bonnet-Brilhault F, Gomot M, Blanc R, David A, Moizard MP, Raynaud M, Ronce N, Lemonnier E, Calvas P, et al. 2004. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. Am J Hum Genet 74(3):552-557.
17. Rehnstrom K, Ylisaukko-oja T, Nieminen-von Wendt T, Sarenius S, Kallman T, Kempas E, von Wendt L, Peltonen L, Jarvela I. 2006. Independent replication and initial fine mapping of 3p 21-24in Asperger syndrome. J Med Genet 43(2):e6.
18. Sacco R, Papaleo V, Hager J, Rousseau F, Moessner R, Militerni R, Bravaccio C, Trillo S, Schneider C, Melmed R, et al. 2007. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC Med Genet 8(1):11.
19. Tafti M, Petit B, Chollet D, Neidhart E, de Bilbao F, Kiss JZ, Wood PA, Franken P. 2003. Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Nat Genet 34(3):320-325.
20. Thornalley PJ. 2003. Glyoxalase I - Structure, function and a critical role in the enzymatic defence against glycation. Biochem Soc Trans 31(Pt 6):1343-1348.
21. World Health Organization. 1993. The ICD-10 Classification of Mental and Behavioural Disorders Diagnostic Criteria for Research. Geneva: WHO.
22. Yang MS, Gill M. 2007. A review of gene linkage, association and expression studies in autism and an assessment of convergent evidence. Int J Dev Neurosci 25(2):69-85.
23. Ylisaukko-oja T, Nieminen-von Wendt T, Kempas E, Sarenius S, Varilo T, von Wendt L, Peltonen L, Jarvela I. 2004. Genome-wide scan for loci of Asperger syndrome. Mol Psychiatry 9(2):161-168.