Evidence of different pharmacokinetics including relationship among AUC, peak, and trough levels between cyclosporine and tacrolimus in renal transplant recipients using new pharmacokinetic parameter - Why cyclosporine is monitored by C2 level and tacrolimus by trough level

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 1, 2008, Pages 90-94

  Takeuchi, Hironori ^a   Matsuno, Naoto ^b   Senuma, Kayoko ^a   Hirano, Toshihiko ^a   Yokoyama, Takayoshi ^b   Taira, Shinichiro ^b   Kihara, Yu ^b   Kuzuoka, Kentaro ^b   Konno, Osamu ^b   Jojima, Yoshimaro ^b   Mejit, Abudushukur ^b   Akashi, Isao ^b   Nakamura, Yuki ^b   Iwamoto, Hitoshi ^b   Hama, Koichiro ^b   Iwahori, Tohru ^b   Ashizawa, Tatsuto ^b   Nagao, Takeshi ^b   Toraishi, Tatsunori ^b   Okuyama, Kiyoshi ^b   Oka, Kitaro ^a   Unezaki, Sakae ^a   more..

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Area under the concentration time curve; Area under the trough level; Blood concentration at 2 h after administration; Cyclosporine; Tacrolimus; Trough concentration

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; CYCLOSPORIN A; MEPREDNISONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; HUMAN; KIDNEY TRANSPLANTATION; MALE; MAXIMUM PLASMA CONCENTRATION;

ADULT; AREA UNDER CURVE; CYCLOSPORINE; DRUG MONITORING; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; TACROLIMUS;

EID: 37848999419     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.90     Document Type: Article

References (12)

1. Wang C. H., Ko W. J., Chou N. K., Wang S. S., Transplant Proc., 36, 2386-2387 (2004).
2. Grevel J., Welsh M. S., Kahan B., Ther. Drug Monit., 11, 246-248 (1989).
3. Meyer M. M., Munar M., Udeaja J., Bennett W., J. Am. Soc. Nephrol., 4, 1306-1315 (1993).
4. Lindholm A., Kahan B. D., Clin. Pharmacol. Ther., 54, 205-217 (1993).
5. Mahalati K., Belitsky P., Sketris I., West K., Panek R., Transplantation, 68, 55-62 (1999).
6. Levy G. A., BioDrugs, 15, 279-290 (2001).
7. Haycock K. A., Roth R., Gagnon J., "Statview," Abacus Concepts, Berkeley, CA, U.S.A.,1994.
8. Mahalati K., Belitsky P., Sketris I., West K., Panek R., Transplantation, 68, 55-62 (1999).
9. Levy G. A., Transplant Proc., 30, 1812-1815 (1998).
10. Miller K. B., Schenkein D. P., Comenzo R., Erban J. K., Fogaren T., Hirsch C. A., Berkman E., Rabson A., Ann. Hematol., 68, 15-20 (1994).
11. Ogawa N., Kanda Y., Matsubara M., Asano Y., Nakagawa M., Sakata-Yanagimoto M., Kandabashi K., Izutsu K., Imai Y., Hangaishi A., Kurokawa M., Tsujino S., Ogawa S., Aoki K., Bone Marrow Transplant., 33, 549-552 (2004).
12. Nakamura Y., Takeuchi H., Okuyama K., Akashi T., Konno O., Jojima Y., Akashi I., Hama K., Iwahori T., Ashizawa T., Hirano T., Oka K., Matsuno N., Nagao T., Transplant Proc., 37, 1725-1727 (2005).