CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling

Biochemical and Biophysical Research Communications

Volumn 366, Issue 3, 2008, Pages 840-847

  Watanabe, Yumi ^a,b   Tsuchiya, Hiroyuki ^a   Sakabe, Tomohiko ^a   Matsuoka, Saori ^a,b   Akechi, Yuji ^a   Fujimoto, Yuka ^a   Yamane, Keitaro ^a   Ikeda, Remina ^a   Nishio, Ren ^a   Terabayashi, Kei ^a   Ishii, Kyoko ^a   Gonda, Kazue ^a   Matsumi, Yoshiaki ^a   Ashla, An Afida ^a   Okamoto, Hideharu ^b   Takubo, Kazuko ^b   Tomita, Akiko ^a   Hoshikawa, Yoshiko ^a   Kurimasa, Akihiro ^a   Itamochi, Hiroaki ^b   Harada, Tasuku ^b   Terakawa, Naoki ^b   Shiota, Goshi ^a   more..

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

CD437; ER stress; IRE1; Ovarian adenocarcinoma; PERK

Indexed keywords

6 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 2 NAPHTHOIC ACID; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELLULAR STRESS SIGNAL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; OVARY ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN INDUCTION; UPREGULATION;

ADENOCARCINOMA; APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; FEMALE; HUMANS; OVARIAN NEOPLASMS; OXIDATIVE STRESS; RETINOIDS; SIGNAL TRANSDUCTION;

EID: 37649023947     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.028     Document Type: Article

References (22)

1. Ozols R.F. Systemic therapy for ovarian cancer: current status and new treatments. Semin. Oncol. 33 (2006) S3-S11
2. McGuire W.P., Hoskins W.J., and Brad M.F. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N. Engl. J. Med. 334 (1996) 1-6
3. Wu S., Zhang D., Donigan A., Dawson M.I., Soprano D.R., and Soprano K.J. Effects of conformationally restricted synthetic retinoids on ovarian tumor cell growth. J. Cell. Biochem. 68 (1998) 378-388
4. Parrella E., Giannì M., Fratelli M., Barzago M.M., Raska Jr. I., Diomede L., Kurosaki M., Pisano C., Carminati P., Merlini L., Dallavalle S., Tavecchio M., Rochette-Egly C., Terao M., and Garattini E. Antitumor activity of the retinoid-related molecules (E)-3-(4′-hydroxy-3′-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: role of retinoic acid receptor gamma and retinoid-independent pathways. Mol. Pharmacol. 70 (2006) 909-924
5. Garattini E., Parrella E., Diomede L., Gianni M., Kalac Y., Merlini L., Simoni D., Zanier R., Ferrara F.F., Chiarucci I., Carminati P., Terao M., and Pisano C. ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood 103 (2004) 194-207
6. Kumar A., Soprano D.R., and Parekh H.K. Cross-resistance to the synthetic retinoid CD437 in a paclitaxel-resistant human ovarian carcinoma cell line is independent of the overexpression of retinoic acid receptor-gamma. Cancer Res. 61 (2001) 7552-7555
7. Liang B., Song X., Liu G., Li R., Xie J., Xiao L., Du M., Zhang Q., Xu X., Gan X., and Huang D. Involvement of TR3/Nur77 translocation to the endoplasmic reticulum in ER stress-induced apoptosis. Exp. Cell Res. 313 (2007) 2833-2844
8. Tsutusmi A., Shiota G., Yamazaki H., Kunisada T., Terada T., and Kawasaki H. Accelerated growth of hepatocytes in association with up-regulation of cyclin E in transgenic mice expressing the dominant negative form of retinoic acid receptor. Biochem. Biophys. Res. Commun. 278 (2000) 229-235
9. Yoshida H., Matsui T., Yamamoto A., Okada T., and Mori K. XBP1 mRNA is induced by p90ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107 (2001) 881-891
10. Soprano D.R., Chen L.X., Wu S., Donigan A.M., Borghaei R.C., and Soprano K.J. Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition. Oncogene 12 (1996) 577-584
11. Ma Y., and Hendershot L.M. Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J. Biol. Chem. 278 (2003) 34864-34873
12. Oyadomari S., and Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 (2004) 381-389
13. Bernard B.A., Bernardon J.M., Delescluse C., Martin B., Lenoir M.C., Maignan J., Charpentier B., Pilgrim W.R., Reichert U., and Shroot B. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem. Biophys. Res. Commun. 186 (1992) 977-983
14. Han Y.H., Cao X., Lin B., Lin F., Kolluri S.K., Stebbins J., Reed J.C., Dawson M.I., and Zhang X.K. Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene 25 (2006) 2974-2986
15. Averous J., Bruhat A., Jousse C., Carraro V., Thiel G., and Fafournoux P. Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J. Biol. Chem. 279 (2004) 5288-5297
16. Yoshida H., Okada T., Haze K., Yanagi H., Yura T., Negishi M., and Mori K. p90ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 20 (2000) 6755-6767
17. Yamamoto K., Yoshida H., Kokame K., Kaufman R.J., and Mori K. Differential contributions of p90ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J. Biochem. (Tokyo) 136 (2004) 343-350
18. Okada T., Yoshida H., Akazawa R.R., Negishi M., and Mori K. Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem. J. 366 (2002) 585-594
19. Zinszner H., Kuroda M., Wang X., Batchvarova N., Lightfoot R.T., Remotti H., Stevens J.L., and Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 12 (1998) 982-995
20. Matsumoto M., Minami M., Takeda K., Sakao Y., and Akira S. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett. 395 (1996) 143-147
21. Ron D., and Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8 (2007) 519-529
22. Haze K., Yoshida H., Yanagi H., Yura T., and Mori K. Mammalian transcription factor p90ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 10 (1999) 3787-3799