Benidipine, an anti-hypertensive drug, inhibits reactive oxygen species production in polymorphonuclear leukocytes and oxidative stress in salt-loaded stroke-prone spontaneously hypertensive rats

European Journal of Pharmacology

Volumn 580, Issue 1-2, 2008, Pages 201-213

  Matsubara, Masahiro ^a   Akizuki, Osamu ^a   Ikeda, Jun ichi ^a   Saeki, Koji ^a   Yao, Kozo ^a   Sasaki, Katsutoshi ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Antioxidant; Benidipine; Polymorphonuclear leukocyte; Reactive oxygen species

Indexed keywords

AMLODIPINE; AZELNIDIPINE; BENIDIPINE; CALCIUM ION; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MESSENGER RNA; NIFEDIPINE; NITRENDIPINE; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SODIUM CHLORIDE; THIOBARBITURIC ACID; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY INJURY; MALE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SALT INTAKE; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE;

ANIMALS; ANTIOXIDANTS; CALCIUM; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; HYPERTENSION; MALE; NADP; NEUTROPHILS; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; REACTIVE OXYGEN SPECIES; SODIUM CHLORIDE, DIETARY; STROKE;

EID: 37649017410     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.10.072     Document Type: Article

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