Use of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (P-15) in the treatment of class II furcation defects: A clinical and radiographic study in humans

Journal of Periodontology

Volumn 78, Issue 12, 2007, Pages 2277-2283

  Eto, Ana L ^a   Joly, Julio C ^a   Jeffcoat, Marjorie ^b   De Araújo, Ney S ^c   De Araújo, Vera C ^a   Cury, Patricia R ^a  

^a SÃO LEOPOLDO MANDIC INSTITUTE AND RESEARCH CENTER   (Brazil)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Clinical trial; Furcation defect; Periodontal regeneration; Periodontitis

Indexed keywords

CELL BINDING PEPTIDE P 15; CELL-BINDING PEPTIDE P-15; COLLAGEN; HYDROXYAPATITE; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG;

ADULT; ANIMAL; ARTICLE; BONE REGENERATION; CATTLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IMAGE SUBTRACTION; MALE; MIDDLE AGED; NONPARAMETRIC TEST; PERIODONTAL DISEASE; PERIODONTITIS; PLASTIC SURGERY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; TOOTH RADIOGRAPHY; TREATMENT OUTCOME;

ADULT; ANIMALS; BONE REGENERATION; CATTLE; COLLAGEN; DOUBLE-BLIND METHOD; DURAPATITE; FEMALE; FURCATION DEFECTS; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PERIODONTITIS; RADIOGRAPHY, BITEWING; STATISTICS, NONPARAMETRIC; SUBTRACTION TECHNIQUE; SURGICAL FLAPS; TREATMENT OUTCOME;

EID: 37648999415     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2007.070234     Document Type: Article

References (31)

1. Jepsen S, Eberhard J, Herrera D, Needleman I. A systematic review of guided tissue regeneration for periodontal furcation defects. What is the effect of guided tissue regeneration compared with surgical debridement in the treatment of furcation defects? J Clin Periodontol 2002;29(Suppl.):s103- s116.
2. Tsao YP, Neiva R, Al-Shammari K, Oh TJ, Wang HL. Factors influencing treatment outcomes in mandibular Class II furcation defects. J Periodontol 2006;77:641-646.
3. Eickholz P, Pretzl B, Holle R, Kim TS. Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. III. Class II furcations after 10 years. J Periodontol 2006;77: 88-94.
4. Tsao YP, Neiva R, Al-Shammari K, Oh TJ, Wang HL. Effects of a mineralized human cancellous bone allograft in regeneration of mandibular Class II furcation defects. J Periodontol 2006;77:416-425.
5. Akbay A, Baran C, Gunhan O, Ozmeric N, Balos K. Periodontal regenerative potential of autogenous periodontal ligament grafts in Class II furcation defects. J Periodontol 2005;76:595-604.
6. Jepsen S, Heinz B, Jepsen K, et al. A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars. Part I: Study design and results for primary outcomes. J Periodontol 2004; 75:1150-1160.
7. Cury PR, Sallum EA, Nociti FH Jr., Sallum AW, Jeffcoatt MK. Long-term results of guided tissue regeneration therapy in the treatment of class II furcation defects: A randomized clinical trial. J Periodontol 2003; 74:3-9.
8. Nevins M, Camelo M, Nevins ML, Schenk RK, Lynch SE. Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone. J Periodontol 2003; 74:1282-1292.
9. Lekovic V, Camargo PM, Weinlaender M, Vasilic N, Aleksic Z, Kenney EB. Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans. J Clin Periodontol 2003;30:746-751.
10. Eickholz P, Kim TS, Holle R, Hausmann E. Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. I. Class II furcations. J Periodontol 2001;72:35-42.
11. De Leonardis D, Garg AK, Pedrazzoli V, Pecora GE. Clinical evaluation of the treatment of class II furcation involvements with bioabsorbable barriers alone or associated with demineralized freeze-dried bone allografts. J Periodontol 1999;70:8-12.
12. Bowers GM, Schallhorn RG, McClain PK, Morrison GM, Morgan R, Reynolds MA. Factors influencing the outcome of regenerative therapy in mandibular Class II furcations: Part I. J Periodontol 2003;74:1255-1268.
13. Qian JJ, Bhatnagar RS. Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen. J Biomed Mater Res 1996; 31:545-554.
14. Bhatnagar RS, Qian JJ, Gough CA. The role in cell binding of a beta-bend within the triple helical region in collagen alpha 1 (I) chain: Structural and biological evidence for conformational tautomerism on fiber surface. J Biomol Struct Dyn 1997;14:547-560.
15. Bhatnagar RS. Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng 1999;5:53-65.
16. Yukna RA, Krauser JT, Callan DP, Evans GH, Cruz R, Martin M. Multi-center clinical comparison of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) and ABM in human periodontal osseous defects. 6-month results. J Periodontol 2000;71:1671-1679.
17. Yukna RA, Callan DP, Krauser JT, et al. Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects. 6-month results. J Periodontol 1998;69:655-663.
18. Roriz VM, Souza SL, Taba M Jr., Palioto DB, Grisi MF. Treatment of Class III furcation defects with expanded polytetrafluoroethylene membrane associated or not with anorganic bone matrix/synthetic cell-binding peptide: A histologic and histomorphometric study in dogs. J Periodontol 2006;77:490-497.
19. Vastardis S, Yukna RA, Mayer ET, Atkinson BL. Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs. J Periodontol 2005;76:1690-1696.
20. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-235.
21. Jeffcoat MK, Reddy MS, van den Berg HR, Bertens E. Quantitative digital subtraction radiography for the assessment of peri-implant bone change. Clin Oral Implants Res 1992;3:22-27.
22. Yukna RA, Krauser JT, Callan DP, Evans GH, Cruz R, Martin M. Thirty-six month follow-up of 25 patients treated with combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) bone replacement grafts in human infrabony defects. I. Clinical findings. J Periodontol 2002;73:123-128.
23. Lindhe J, Palmer R. Group C summary. J Clin Periodontol 2002;29(Suppl. 3):S160-S162.
24. Vuddhakanok S, Solt CW, Mitchell JC, Foreman DW, Alger FA. Histologic evaluation of periodontal attachment apparatus following the insertion of a biodegradable copolymer barrier in humans. J Periodontol 1993; 64:202-210.
25. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol 1989;60:683-693.
26. Caton J, Nyman S, Zander H. Histometric evaluation of periodontal surgery. II. Connective tissue attachment levels after four regenerative procedures. J Clin Periodontol 1980;7:224-231.
27. Yukna R, Salinas TJ, Carr RF. Periodontal regeneration following use of ABM/P-15: A case report. Int J Periodontics Restorative Dent 2002;22:146-155.
28. Cugini MA, Haffajee AD, Smith C, Kent RL Jr., Socransky SS. The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 2000;27:30-36.
29. Bhatnagar RS, Qian JJ, Wedrychowska A, Sadeghi M, Wu YM, Smith N. Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng 1999;5:53-65.
30. Yang XB, Bhatnagar RS, Li S, Oreffo RO. Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Eng 2004;10:1148-1159.
31. Bhatnagar RS, Qian JJ, Wedrychowska A, Dixon E, Smith N. Biomimetic habitats for cells: Ordered matrix deposition and differentiation in gingival fibroblast cultured on hydroxyapatite coated with a collagen analogue. Cells Mater 1999;9:93-104.