Quantitative analysis of ciliary ultrastructure in patients with primary ciliary dyskinesia

Acta Histochemica

Volumn 110, Issue 1, 2008, Pages 34-41

  Sirvanci, Serap ^a   Seda Uyan, Z ^b   Ercan, Feriha ^a   Karadag, Bulent ^b   Ersu, Refika ^b   Karakoc, Fazilet ^b   Dagli, Elif ^b   San, Tangul ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b Section of Pediatric Epileptology and Video EEG Lab Acibadem   (Turkey)

Author keywords

Cilia; Primary ciliary dyskinesia; Quantitative analysis; Ultrastructure

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; GLUTARALDEHYDE;

ADULT; ARTICLE; CELL ULTRASTRUCTURE; CHILD; CILIARY DYSKINESIA; CILIATED EPITHELIUM; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN CELL; LOWER RESPIRATORY TRACT INFECTION; MALE; MICROTUBULE; MICROTUBULE ASSEMBLY; NOSE MUCOSA; PROTEIN DEFICIENCY; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RECURRENT DISEASE; SCHOOL CHILD; STATISTICAL ANALYSIS; UPPER RESPIRATORY TRACT INFECTION;

EID: 37549072286     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2007.05.006     Document Type: Article

References (38)

1. Afzelius B.A. A human syndrome caused by immotile cilia. Science 193 (1976) 317-319
2. Afzelius B.A. Immotile-cilia syndrome: ultrastructural features. Eur J Respir Dis 63 Suppl.118 (1982) 117-122
3. Afzelius B.A. The immotile-cilia syndrome: a microtubule-associated defect. CRC Crit Rev Biochem 19 (1985) 63-87
4. Boat T.F., and Carson J.L. Ciliary dysmorphology and dysfunction: primary or acquired?. N Engl J Med 323 (1990) 1700-1702
5. Brody S.L. Genetic regulation of cilia assembly and the relationship to human disease. Am J Respir Cell Mol Biol 30 (2004) 435-437
6. Bush A., and O'Callaghan C. Primary ciliary dyskinesia. Arch Dis Child 12 (2002) 363-365
7. Chilvers M.A., Rutman A., and O'Callaghan C. Functional analysis of cilia and ciliated epithelial ultrastructure in healthy children and young adults. Thorax 58 (2003) 333-338
8. Chilvers M.A., Rutman A., and O'Callaghan C. Primary ciliary dyskinesia: ciliary beat pattern is associated with specific ultrastructural defects. J Allergy Clin Immunol 112 (2003) 518-524
9. De Boeck K., Jorissen M., Wonters K., Van der Schueren B., Eyssen M., Casteels-Van Daele M., et al. Aplasia of respiratory tract cilia. Pediatr Pulmonol 13 (1992) 259-265
10. De Iongh R.U., and Rutland J. Ciliary defects in healthy subjects, bronchiectasis and primary ciliary dyskinesia. Am J Respir Crit Care Med 152 (1995) 1559-1567
11. Ehouman A., Pinchon M.C., Escudier E., and Bernaudin J.F. Ultrastructural abnormalities of respiratory cilia. Descriptive and quantitative study of respiratory mucosa in a series of 33 patients. Virch Arch (Cell Biol) 48 (1985) 87-95
12. Eliasson R., Mossberg B., Camner P., and Afzelius B.A. The immotile-cilia syndrome: a congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. N Engl J Med 297 (1977) 1-6
13. Guichard C., Harricane M.C., Lafitte J.J., Godard P., Zaegel M., Tack V., et al. Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). Am J Hum Genet 68 (2001) 1030-1035
14. Harris G.B., Bermejo J.C.R., and Suarez M.C. Different frequency of cilia with transposition in human nasal and bronchial mucosa. A case of acquired ciliary dyskinesia. Virch Arch 437 (2000) 325-330
15. Ibañez-Tallon I., Heintz N., and Orman H. To beat or not to beat: roles of cilia in development and disease. Hum Mol Genet 12 1 (2003) R27-R35
16. Jorissen M., Bertrand B., and Eloy P. Ciliary dyskinesia in the nose and paranasal sinuses. Acta Otorhinolaryngol Belg 51 (1997) 353-366
17. Jorissen M., and Willems T. Success rates of respiratory epithelial cell culture techniques with ciliogenesis for diagnosing primary ciliary dyskinesia. Acta Otorhinolaryngol Belg 54 (2000) 357-365
18. Jorissen M., Willems T., Van der Schueren B., and Verbeken E. Secondary ciliary dyskinesia is absent after ciliary genesis in culture. Acta Otorhinolaryngol Belg 54 (2000) 333-342
19. Konrádová V., Vavrová V., Hlousková Z., Copova M., Tománek A., and Houstek J. Ultrastructure of bronchial epithelium in children with chronic or recurrent respiratory diseases. Eur J Respir Dis 63 (1982) 516-525
20. McDowell E.M., Barret L.A., Harris C.C., and Trump B.F. Abnormal cilia in human bronchial epithelium. Arch Pathol Lab Med 100 (1976) 426-436
21. Meeks M., and Bush A. Primary ciliary dyskinesia (PCD). Pediatr Pulmonol 29 (2000) 307-316
22. Mierau G.W., Agostini B.R., Bealls T.F., Carlén B., Dardick I., Henderson D.N., et al. The role of electron microscopy in evaluating ciliary dysfunction. Report of a workshop. Ultrastruct Pathol 16 (1992) 245-254
23. Moreau M.F., Chretien M.F., Dubin J., Rebel A., and Malkani K. Transposed ciliary microtubules in Kartagener's syndrome: a case report with electron microscopy of bronchial and nasal brushings. Acta Cytol 29 (1985) 248-253
24. Mygind N., Pedersen M., and Nielsen M. Primary and secondary ciliary dyskinesia. Acta Otolaryngol 95 (1983) 688-694
25. Narayan D., Krishnan S.N., Upender M., Ravikumar T.S., Mahoncy M.J., Dolan Jr. T.F., et al. Unusual inheritance of primary ciliary dyskinesia (Kartagener's syndrome). J Med Genet 31 (1994) 493-496
26. Ostrowski L.E., Blackburn K., Radde K.M., Moyer M.B., Schlatzer D.M., Moseley A., et al. A proteomic analysis of human cilia: identification of novel components. Mol Cell Proteomics 1 (2002) 451-465
27. Pifferi M., Cangiotti A.M., Ragazzo V., Baldini G., Cinti S., and Boner A.L. Primary ciliary dyskinesia: diagnosis in children with inconclusive ultrastructural evaluation. Pediatr Allergy Immunol 12 (2001) 274-282
28. Polosukhin V.V. Ultrastructure of the bronchial epithelium in chronic inflammation. Ultrastruct Pathol 25 (2001) 119-128
29. Robson A.M., Smallman L.A., Gregory J., and Drake-Lee A.B. Ciliary ultrastructure in nasal brushings. Cytopathology 4 (1993) 149-159
30. Rossman C.M., Lee R.M.K.W., Forrest J.B., and Newhouse M.T. Nasal ciliary ultrastructure and function in patient with primary ciliary dyskinesia compared with that in normal subjects and in subjects with various respiratory disease. Am Rev Respir Dis 129 (1984) 161-167
31. Rubin B.K. Immotile cilia syndrome (primary ciliary dyskinesia) and inflammatory lung disease. Clin Chest Med 9 4 (1988) 657-668
32. Schneeberger E.E., McCormack J., Issenberg H.J., Schuster S.R., and Gerald P.S. Heterogeneity of ciliary morphology in the immotile cilia syndrome in man. J Ultrastruct Res 73 (1980) 34-43
33. Sleigh M.A. Primary ciliary dyskinesia. Lancet 2 (1981) 476
34. Sturguess J.M., Chao J., Wong J., Aspin N., and Turner J.A.P. Cilia with defective radial spokes: a cause of human respiratory disease. N Engl J Med 300 (1979) 53-56
35. Sturgess J.M., Chao J., and Turner J.A.P. Transposition of ciliary microtubules: another cause of impaired ciliary motility. N Engl J Med 303 (1980) 318-322
36. Toledo M.F., and Adde F.V. Primary ciliary dyskinesia in children. J Pediatr (Rio J) 76 1 (2000) 9-16
37. Torkkeli T., Rautiainen M., and Nuutinen J. Long-term follow-up of the clinical relevance of short outer dynein arms in human nasal cilia. Eur Arch Otorhinolaryngol 255 (1998) 495-498
38. Van der Baan S., Veerman A.J.P., Bezemer P.D., and Feenstra L. Primary ciliary dyskinesia: quantitative investigation of the ciliary ultrastructure with statistical analysis. Ann Otol Rhinol Laryngol 96 (1987) 264-272