Influence of verapamil on tachycardia-induced alterations of PP1 and PP2A in rabbit atrium

Experimental and Clinical Cardiology

Volumn 12, Issue 4, 2007, Pages 175-178

  Laszlo, Roman ^a   Winkler, Christoph ^a   Wöhrl, Stefan ^a   Laszlo, Sara ^a   Eick, Christian ^a   Schreieck, Jürgen ^a   Bosch, Ralph F ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Kardiologische Praxis Asperger Straße   (Germany)

Author keywords

Atrial fibrillation; Atrial remodelling; L type Ca2+ channel; PP1; PP2A

Indexed keywords

CALCIUM CHANNEL L TYPE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEART ATRIUM FIBRILLATION; NONHUMAN; PROTEIN EXPRESSION; RABBIT; WESTERN BLOTTING;

EID: 37549069706     PISSN: 12056626     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Hennersdorf MG, Perings C, Kelm M, Strauer BE. [Atrial fibrillation.] Internist (Berl) 2001;42:1631-40.
2. Dobrev D, Ravens U. Remodeling of cardiomyocyte ion channels in human atrial fibrillation. Basic Res Cardiol 2003;98:137-48.
3. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995;92:1954-68.
4. Bosch RF, Zeng X, Grammer JB, Popovic K, Mewis C, Kühlkamp V. Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc Res 1999;44:121-31.
5. Bosch RF, Scherer CR, Rüb N, et al. Molecular mechanisms of early electrical remodeling: Transcriptional downregulation of ion channel subunits reduces I(Ca,L) and I(to) in rapid atrial pacing in rabbits. J Am Coll Cardiol 2003;41:858-69.
6. 2+ currents and human atrial fibrillation. Circ Res 1999;85:428-36.
7. Workman AJ, Kane KA, Rankin AC. The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res 2001;52:226-35.
8. Brundel BJ, Van Gelder IC, Henning RH, et al. Gene expression of proteins influencing the calcium homeostasis in patients with persistent and paroxysmal atrial fibrillation. Cardiovasc Res 1999;42:443-54.
9. Lai LP, Su MJ, Lin JL, et al. Down-regulation of L-type calcium channel and sarcoplasmic reticular Ca(2+)-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor, calsequestrin and phospholamban: An insight into the mechanism of atrial electrical remodeling. J Am Coll Cardiol 1999;33:1231-7.
10. Van Gelder IC, Brundel BJ, Henning RH, et al. Alterations in gene expression of proteins involved in the calcium handling in patients with atrial fibrillation. J Cardiovasc Electrophysiol 1999;10:552-60.
11. 2+-channel, beta-adrenoreceptor, and 5-hydroxytryptamine type 4 receptor mRNAs in human atrial fibrillation. Basic Res Cardiol 2001;96:82-90.
12. 2+-channel subunits alpha1C and beta2 are not downregulated in atrial myocardium of patients with chronic atrial fibrillation. J Mol Cell Cardiol 2003;35:437-43.
13. 2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases. Circulation 2004;110:2651-7.
14. Kamp TJ, Hell JW. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ Res 2000;87:1095-102.
15. 2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx. Proc Natl Acad Sci U S A 1994;91:9659-63.
16. Herzig S, Neumann J. Effects of serine/threonine protein phosphatases on ion channels in excitable membranes. Physiol Rev 2000;80:173-210.
17. Hagiwara S, Byerly L. Calcium channel. Annu Rev Neurosci 1981;4:69-125.
18. Hofmann F, Lacinová L, Klugbauer N. Voltage-dependent calcium channels: From structure to function. Rev Physiol Biochem Pharmacol 1999;139:33-87.
19. Reuter H. Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature 1983;301:569-74.
20. 2+ channel affecting different kinetic functions. J Physiol 1993;470:73-84.
21. Wessel RE, Wöhrl S, Gogel J, et al. Prevention of tachycardia induced cellular electrical remodelling by verapamil in rabbit atria. Eur Heart J 2004;25(Suppl 1):478. (Abst)
22. Davison R, Hartz R, Kaplan K, Parker M, Feiereisel P, Michaelis L. Prophylaxis of supraventricular tachyarrhythmia after coronary bypass surgery with oral verapamil: A randomized, double-blind trial. Ann Thorac Surg 1985;39:336-9.
23. Seitelberger R, Hannes W, Gleichauf M, Keilich M, Christoph M, Fasol R. Effects of diltiazem on perioperative ischemia, arrhythmias, and myocardial function in patients undergoing elective coronary bypass grafting. J Thorac Cardiovasc Surg 1994;107:811-21.
24. Smith EE, Shore DF, Monro JL, Ross JK. Oral verapamil fails to prevent supraventricular tachycardia following coronary artery surgery. Int J Cardiol 1985;9:37-44.
25. Tieleman RG, Van Gelder IC, Crijns HJ, et al. Early recurrences of atrial fibrillation after electrical cardioversion: A result of fibrillation-induced electrical remodeling of the atria? J Am Coll Cardiol 1998;31:167-73.
26. Kurita Y, Mitamura H, Shiroshita-Takeshita A, et al. Daily oral verapamil before but not after rapid atrial excitation prevents electrical remodeling. Cardiovasc Res 2002;54:447-55.
27. Kinebuchi O, Mitamura H, Shiroshita-Takeshita A, et al. Oral verapamil attenuates the progression of pacing-induced electrical and mechanical remodeling of the atrium. Circ J 2004;68:494-500.
28. Moriguchi M, Niwano S, Yoshizawa N, Kojima J, Inuo K, Izumi T. Verapamil suppresses the inhomogeneity of electrical remodeling in a canine long-term rapid atrial stimulation model. Pacing Clin Electrophysiol 2003;26:2072-82.
29. Daoud EG, Knight BP, Weiss R, et al. Effect of verapamil and procainamide on atrial fibrillation-induced electrical remodeling in humans. Circulation 1997;96:1542-50.
30. Fareh S, Bénardeau A, Nattel S. Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs. Cardiovasc Res 2001;49:762-70.
31. Lee SH, Yu WC, Cheng JJ, et al. Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling. Circulation 2000;101:200-6.
32. Duytschaever MF, Garratt CJ, Allessie MA. Profibrillatory effects of verapamil but not of digoxin in the goat model of atrial fibrillation. J Cardiovasc Electrophysiol 2000;11:1375-85.
33. Shenasa M, Kus T, Fromer M, LeBlanc RA, Dubuc M, Nadeau R. Effect of intravenous and oral calcium antagonists (diltiazem and verapamil) on sustenance of atrial fibrillation. Am J Cardiol 1988;62:403-7.