Back to the future: The ribosome as an antibiotic target

Future Microbiology

Volumn 2, Issue 6, 2007, Pages 571-574

  Franceschi, François ^a  

^a Rib X Pharmaceuticals Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; AZITHROMYCIN; BACTERIAL RNA; CHLORAMPHENICOL; CLARITHROMYCIN; CLINDAMYCIN; DALFOPRISTIN PLUS QUINUPRISTIN; FLORFENICOL; KETOLIDE; LINCOSAMIDE; LINEZOLID; MACROLIDE; MESSENGER RNA; OXAZOLIDINONE DERIVATIVE; PEPTIDYLTRANSFERASE; RIBOSOME RNA; SPARSOMYCIN; STREPTOGRAMIN; TETRACYCLINE; THIAZOLE DERIVATIVE; TIAMULIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTERIAL MEMBRANE; BINDING AFFINITY; CLINICAL TRIAL; DRUG BINDING; DRUG DESIGN; DRUG RESEARCH; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; EDITORIAL; HOSPITAL INFECTION; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIDRUG RESISTANCE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; QUANTITATIVE ANALYSIS; RIBOSOME; RNA TRANSLATION;

ANTI-BACTERIAL AGENTS; BACTERIA; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; RIBOSOMES;

EID: 37549066311     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460913.2.6.571     Document Type: Editorial

References (26)

1. NIAID. The problem of antibiotic resistance, NIAID fact sheet. April 2006. NIAID (2006).
2. Klevens RM, Morrison MA, Nadle J et al.: Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298, 1763-1771 (2007).
3. Maaloe O: Regulation of the protein synthesis machinery. In: Biological Regulation and Development. Goldberg RF (Ed.). Vol. 1. Plenum Publishing Corp., NY, USA 487-542 (1979).
4. Ban N, Nissen P, Hansen J, Moore PB, Steitz TA: The complete atomic structure of the large ribosomal subunit at 2.4 angstrom resolution. Science 289, 905-920 (2000).
5. Harms J, Schluenzen F, Zarivach R et al.: High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. Cell 107, 679-688 (2001).
6. Schluenzen F, Tocilj A, Zarivach R et al.: Structure of functionally activated small ribosomal subunit at 3.3 angstrom resolution. Cell 102, 615-623 (2000).
7. Wimberly BT, Brodersen DE, Clemons WM Jr et al.: Structure of the 30S ribosomal subunit. Nature 407, 327-39 (2000).
8. Brodersen DE, Clemons WM, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V: The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell 103, 1143-1154 (2000).
9. Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V: Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 407, 340-348 (2000).
10. Hansen JL, Ippolito JA, Ban N, Nissen P, Moore PB, Steitz TA: The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell 10, 117-128 (2002).
11. Hansen JL, Moore PB, Steitz TA: Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J. Mol. Biol. 330, 1061-1075 (2003).
12. Pioletti M, Schlunzen F, Harms J et al.: Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J. 20, 1829-1839 (2001).
13. Schlunzen F, Harms JM, Franceschi F et al.: Structural basis for the antibiotic activity of ketolides and azalides. Structure 11, 329-338 (2003).
14. Schlunzen F, Zarivach R, Harms J et al.: Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413, 814-821 (2001).
15. Tu D, Blaha G, Moore PB, Steitz TA: Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell 121, 257-270 (2005).
16. Vicens, Q, Westhof E: Crystal structure of paromomycin docked into the eubacterial ribosomal decoding a site. Structure 9, 647-658 (2001).
17. Vicens Q, Westhof E: Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. Chem. Biol. 9, 747-755 (2002).
18. Steitz TA, Moore PB: RNA, the first macromolecular catalyst: the ribosome is a ribozyme. Trends Biochem. Sci. 28, 411-418 (2003).
19. Nissen P, Hansen J, Ban N, Moore PB, Steitz TA: The structural basis of ribosome activity in peptide bond synthesis. Science 289, 920-930 (2000).
20. Zhou YF, Gregor VE, Sun ZX et al.: Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors. Antimicrob. Agents Chemother. 49, 4942-4949 (2005).
21. Russell RJM, Murray JB, Lentzen G, Haddad J, Mobashery S: The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by x-ray crystallography. J. Am. Chem. Soc. 125, 3410-3411 (2003).
22. Franceschi F, Duffy EM: Structure-based drug design meets the ribosome. Biochem. Pharmacol. 71, 1016-1025 (2006).
23. χ-01: A new family of oxazolidinones that overcomes ribosomal-based linezolid resistance. Antimicrob. Agents Chemother. Submitted (2007).
24. χ-01, a novel oxazolidinone class, to bacterial ribosomes. Presented at: Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA, 16-19 December 2005.
25. Zhou J, Bhattacharjee A, Chem S et al.: Design at the atomic level: synthesis of biaryl oxazolidinones as potent, orally active antibiotics. Presented at: Interscience Conference on Antimicrobial Agents and Chemotheraphy. Washington DC, USA, 16-19 December 2005.
26. Douthwaite S: Functional interactions within 23S-ribosomal-RNA involving the peptidyltransferase center. J. Bacteriol. 174, 1333-1338 (1992).