Targeted contrast agent helps to monitor advanced plaque during progression: A magnetic resonance imaging study in rabbits

Investigative Radiology

Volumn 43, Issue 1, 2008, Pages 49-55

  Zheng, Jie ^a   Ochoa, Elizabeth ^a   Misselwitz, Bernd ^b   Yang, Deshan ^a   El Naqa, Issam ^a   Woodard, Pamela K ^a   Abendschein, Dana ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYER PHARMA AG   (Germany)

Author keywords

Atherosclerosis; Gadofluorine; MRI; Neointima; Progression

Indexed keywords

CONTRAST MEDIUM; GADOFLUORINE M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY WALL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL DIET; CONTRAST TO NOISE RATIO; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; FEMORAL ARTERY; FOAM CELL; HISTOPATHOLOGY; INTIMA; MATHEMATICAL PARAMETERS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER;

EID: 37549055422     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/RLI.0b013e318155aa5a     Document Type: Article

References (19)

1. Tsimikas S, Shaw PX. Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies. J Cell Biochem Suppl. 2002;39:138-146.
2. Skinner MP, Yuan C, Mitsumori L, et al. Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complications in vivo. Nat Med. 1995;1:69-73.
3. McConnell MV, Aikawa M, Maier SE, et al. MRI of rabbit atherosclerosis in response to dietary cholesterol lowering. Arterioscler Thromb Vasc Biol. 1999;19:1956-1959.
4. Helft G, Worthley SG, Fuster V, et al. Progression and regression of atherosclerotic lesions: monitoring with serial noninvasive magnetic resonance imaging. Circulation. 2002;105:993-998.
5. Corti R, Osende JI, Fallon JT, et al. The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging. J Am Coll Cardiol. 2004;43:464-473.
6. Hegyi L, Hockings PD, Benson MG, et al. Short term arterial remodelling in the aortae of cholesterol fed New Zealand white rabbits shown in vivo by high-resolution magnetic resonance imaging-implications for human pathology. Pathol Oncol Res. 2004;10:159-165.
7. Corti R, Osende J, Hutter R, et al. Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI. Atherosclerosis. 2007;190:106-113.
8. Steen H, Kolmakova A, Stuber M, et al. MRI visualized neo-intimal dissection and co-localization of novel apoptotic markers apolipoprotein C-1, ceramide and caspase-3 in a Watanabe hyperlipidemic rabbit model. Atherosclerosis. 2007;191:82-89.
9. Barkhausen J, Ebert W, Heyer C, et al. Detection of atherosclerotic plaque with Gadofluorine-enhanced magnetic resonance imaging. Circulation. 2003;108:605-609.
10. Sirol M, Itskovich VV, Mani V, et al. Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging. Circulation. 2004;109:2890-2896.
11. Koktzoglou I, Harris KR, Tang R, et al. Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine. Invest Radiol. 2006;41:299-304.
12. Meding J, Misselwitz B, Weinmann HJ. The mechanism of gadofluorine accumulation in atherosclerotic lesions. Constrast Media Mol Imaging. 2006;1:61.
13. Sarembock IJ, LaVeau PJ, Sigal SL, et al. Influence of inflation pressure and balloon size on the development of intimal hyperplasia after balloon angioplasty. A study in the atherosclerotic rabbit. Circulation. 1989;80:1029-1040.
14. Misselwitz B, Platzek J, Weinmann HJ. Early MR lymphography with gadofluorine M in rabbits. Radiology. 2004;231:682-688.
15. Gertz SD, Barry WL, Gimple LW, et al. Predictors of luminal narrowing by neointima after angioplasty in atherosclerotic rabbits. Cardiovasc Res. 1997;36:396-407.
16. Giesel FL, Stroick M, Griebe M, et al. Gadofluorine m uptake in stem cells as a new magnetic resonance imaging tracking method: an in vitro and in vivo study. Invest Radiol. 2006;41:868-873.
17. Peukert D, Kaufels N, Laule M, et al. Improved evaluation of myocardial perfusion and viability with the magnetic resonance blood pool contrast agent p792 in a nonreperfused porcine infarction model. Invest Radiol. 2007;42:248-255.
18. Eldredge HB, Spiller M, Chasse JM, et al. Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325. Invest Radiol. 2006;41:229-243.
19. de Haën C, Anelli PL, Lorusso V, et al. Gadocoletic acid trisodium salt (b22956/1): a new blood pool magnetic resonance contrast agent with application in coronary angiography. Invest Radiol. 2006;41:279-291.