The nimorazole regimen in patients with head and neck cancer can increase the effect of vitamin K antagonists [1]

Acta Oncologica

Volumn 47, Issue 1, 2008, Pages 150-151

  Bjarnason, Nina H ^a,b   Christiansen, Michael ^c   Specht, Lena ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVITAMIN K; DICLOFENAC; FLUCONAZOLE; NIMORAZOLE; PHENPROCOUMON;

AGED; CANCER RADIOTHERAPY; CANCER THERAPY; CASE REPORT; DRUG ANTAGONISM; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEAD AND NECK CANCER; HEART ATRIUM FIBRILLATION; HEMATEMESIS; HEMATURIA; HEMOPTYSIS; HUMAN; LETTER; MALE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; DRUG INTERACTIONS; FEMALE; FIBRINOLYSIS; GLOTTIS; HEAD AND NECK NEOPLASMS; HUMANS; HYPOPHARYNGEAL NEOPLASMS; INTERNATIONAL NORMALIZED RATIO; LARYNGEAL NEOPLASMS; MALE; NIMORAZOLE; VITAMIN K;

EID: 37549055123     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.1080/02841860701381242     Document Type: Letter

References (5)

1. Wells PS, Holbrook AM, Crowther NR, Hirsh J. Interactions of warfarin with drugs and food. Ann Intern Med 1994;121:676-83.
2. O'Reilly RA. The stereoselective interaction of warfarin and metronidazole in man. N Engl J Med 1976;295:354-7.
3. Overgaard J, Hansen HS, Overgaard M, Bastholt L, Berthelsen A, Specht L, et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 1998;46:135-46.
4. Bjarnason NH, Specht L, Dalhoff K. Nimorazole may increase the effect of phenprocoumon. Radiother Oncol 2005;74:345.
5. Joffe HV, Xu R, Johnson FB, Longtine J, Kucher N, Goldhaber SZ. Warfarin dosing and cytochrome P450 2C9 polymorphisms. Thromb Haemost 2004;91:1123-8.