메뉴 건너뛰기




Volumn 20, Issue 1, 2008, Pages 141-154

Massive but selective cytokine dysregulation in the colon of IL-10-/- mice revealed by multiplex analysis

Author keywords

Cell activation; Chemokine; Cytokine; Mucosa; Rodent

Indexed keywords

CXCL1 CHEMOKINE; EOTAXIN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA;

EID: 37549047983     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm126     Document Type: Article
Times cited : (16)

References (51)
  • 1
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. and Muller, W. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
    • (1993) Cell , vol.75 , pp. 263
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 2
    • 0027922467 scopus 로고
    • Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    • Mombaerts, P., Mizoguchi, E., Grusby, M, J., Glimcher, L. H., Bhan, A. K. and Tonegawa, S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75:274.
    • (1993) Cell , vol.75 , pp. 274
    • Mombaerts, P.1    Mizoguchi, E.2    Grusby, M.J.3    Glimcher, L.H.4    Bhan, A.K.5    Tonegawa, S.6
  • 4
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon, R. K., Tonkonogy, S., Schultz, M. et al. 1998. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66:5224.
    • (1998) Infect. Immun , vol.66 , pp. 5224
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3
  • 5
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • Strober, W., Fuss, I. J. and Blumberg, R. S. 2002. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495.
    • (2002) Annu. Rev. Immunol , vol.20 , pp. 495
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3
  • 6
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    • Berg, D. J., Davidson, N., Kuhn, R. et al. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Investig. 98:1010.
    • (1996) J. Clin. Investig , vol.98 , pp. 1010
    • Berg, D.J.1    Davidson, N.2    Kuhn, R.3
  • 7
    • 33646058313 scopus 로고    scopus 로고
    • Induction of chronic colitis in IL-10 deficient mice requires IL-4
    • Specht, S., Arriens, S. and Hoerauf, A. 2006. Induction of chronic colitis in IL-10 deficient mice requires IL-4. Microbes Infect. 8:694.
    • (2006) Microbes Infect , vol.8 , pp. 694
    • Specht, S.1    Arriens, S.2    Hoerauf, A.3
  • 8
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen, D., Cheung, J., Scheerens, H. et al. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Investig. 116:1310.
    • (2006) J. Clin. Investig , vol.116 , pp. 1310
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 9
    • 8344242910 scopus 로고    scopus 로고
    • IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice
    • Shiraki, M., Aihara, H., Kinouchi, Y. et al. 2004. IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice. Lab. Investig. 84:1491.
    • (2004) Lab. Investig , vol.84 , pp. 1491
    • Shiraki, M.1    Aihara, H.2    Kinouchi, Y.3
  • 10
    • 0030018186 scopus 로고    scopus 로고
    • T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    • Davidson, N. J., Leach, M. W., Fort, M. M. et al. 1996. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J. Exp. Med. 184:241.
    • (1996) J. Exp. Med , vol.184 , pp. 241
    • Davidson, N.J.1    Leach, M.W.2    Fort, M.M.3
  • 11
    • 0034128634 scopus 로고    scopus 로고
    • Claudins regulate the intestinal barrier in response to immune mediators
    • Kinugasa, T., Sakaguchi, T., Gu, X. and Reinecker, H. C. 2000. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118:1001.
    • (2000) Gastroenterology , vol.118 , pp. 1001
    • Kinugasa, T.1    Sakaguchi, T.2    Gu, X.3    Reinecker, H.C.4
  • 12
    • 0028101467 scopus 로고
    • IL-4 directly modulates function of a model human intestinal epithelium
    • Colgan, S. P., Resnick, M. B., Parkos, C. A. et al. 1994. IL-4 directly modulates function of a model human intestinal epithelium. J. Immunol. 153:2122.
    • (1994) J. Immunol , vol.153 , pp. 2122
    • Colgan, S.P.1    Resnick, M.B.2    Parkos, C.A.3
  • 13
    • 0000418018 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6
    • Schmitz, H., Fromm, M., Bentzel, C. J. et al. 1999. Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J. Cell Sci. 112:137.
    • (1999) J. Cell Sci , vol.112 , pp. 137
    • Schmitz, H.1    Fromm, M.2    Bentzel, C.J.3
  • 14
    • 0032977248 scopus 로고    scopus 로고
    • Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin
    • Youakim, A. and Ahdieh, M. 1999, Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am. J. Physiol. 276:G1279.
    • (1999) Am. J. Physiol , vol.276
    • Youakim, A.1    Ahdieh, M.2
  • 15
    • 0033565947 scopus 로고    scopus 로고
    • Cutting edge: Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells
    • Ozaki, H., Ishii, K., Horiuchi, H. et al. 1999. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J. Immunol. 163:553.
    • (1999) J. Immunol , vol.163 , pp. 553
    • Ozaki, H.1    Ishii, K.2    Horiuchi, H.3
  • 16
    • 0035047036 scopus 로고    scopus 로고
    • Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11
    • Lui, W. Y., Lee, W. M. and Cheng, C. Y. 2001. Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11. Endocrinology 142: 1865.
    • (2001) Endocrinology , vol.142 , pp. 1865
    • Lui, W.Y.1    Lee, W.M.2    Cheng, C.Y.3
  • 17
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells
    • Nusrat, A., Turner, J. R. and Madara, J. L. 2000. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G851.
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol , vol.279
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 18
    • 0030969845 scopus 로고    scopus 로고
    • Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain
    • Stevens, A. C., Matthews, J., Andres, P. et al. 1997. Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain. Am. J. Physiol. 272:G1201.
    • (1997) Am. J. Physiol , vol.272
    • Stevens, A.C.1    Matthews, J.2    Andres, P.3
  • 19
    • 33749007683 scopus 로고    scopus 로고
    • Inflammatory bowel disease and the apical junctional complex
    • Bruewer, M., Samarin, S. and Nusrat, A. 2006. Inflammatory bowel disease and the apical junctional complex. Ann. N. Y. Acad. Sci. 1072:242.
    • (2006) Ann. N. Y. Acad. Sci , vol.1072 , pp. 242
    • Bruewer, M.1    Samarin, S.2    Nusrat, A.3
  • 20
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath, M. F., Fuss, I., Kelsall, B. L., Stuber, E. and Strober, W. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281.
    • (1995) J. Exp. Med , vol.182 , pp. 1281
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 21
    • 30844452189 scopus 로고    scopus 로고
    • An improved method for isolating intraepithelial lymphocytes (IELs) from the murine small intestine with consistently high purity
    • Montufar-Solis, D. and Klein, J. R. 2006. An improved method for isolating intraepithelial lymphocytes (IELs) from the murine small intestine with consistently high purity. J. Immunol. Methods 308:251.
    • (2006) J. Immunol. Methods , vol.308 , pp. 251
    • Montufar-Solis, D.1    Klein, J.R.2
  • 22
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
    • Livak, K. J. and Schmittgen, T. D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25:402.
    • (2001) Methods , vol.25 , pp. 402
    • Livak, K.J.1    Schmittgen, T.D.2
  • 23
    • 10744229101 scopus 로고    scopus 로고
    • Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis
    • Ishii, K., Kanai, T., Totsuka, T. et al. 2004. Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. J. Gastroenterol. Hepatol. 19:174.
    • (2004) J. Gastroenterol. Hepatol , vol.19 , pp. 174
    • Ishii, K.1    Kanai, T.2    Totsuka, T.3
  • 24
    • 0037309841 scopus 로고    scopus 로고
    • Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis
    • Totsuka, T., Kanai, T, Iiyama, R. et al. 2003. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology 124:410.
    • (2003) Gastroenterology , vol.124 , pp. 410
    • Totsuka, T.1    Kanai, T.2    Iiyama, R.3
  • 25
    • 10744221436 scopus 로고    scopus 로고
    • Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease
    • Sato, T., Kanai, T., Watanabe, M. et al. 2004. Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. Gastroenterology 126:829.
    • (2004) Gastroenterology , vol.126 , pp. 829
    • Sato, T.1    Kanai, T.2    Watanabe, M.3
  • 26
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park, H., Li, Z., Yang, X. O. et al. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6:1133.
    • (2005) Nat. Immunol , vol.6 , pp. 1133
    • Park, H.1    Li, Z.2    Yang, X.O.3
  • 27
    • 0034541221 scopus 로고    scopus 로고
    • Microbial lipopeptides induce the production of IL-17 in Th cells
    • Infante-Duarte, C., Horton, H. F., Byrne, M. C. and Kamradt, T. 2000. Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol. 165:6107.
    • (2000) J. Immunol , vol.165 , pp. 6107
    • Infante-Duarte, C.1    Horton, H.F.2    Byrne, M.C.3    Kamradt, T.4
  • 28
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L. E., Hatton, R. D., Mangan, P. R. et al. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6:1123.
    • (2005) Nat. Immunol , vol.6 , pp. 1123
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 29
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue, S., Ahern, P., Buonocore, S. et al. 2006. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J. Exp. Med. 203:2473.
    • (2006) J. Exp. Med , vol.203 , pp. 2473
    • Hue, S.1    Ahern, P.2    Buonocore, S.3
  • 30
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal, S., Ghilardi, N., Xie, M. H., de Sauvage, F. J. and Gurney, A. L. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278:1910.
    • (2003) J. Biol. Chem , vol.278 , pp. 1910
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 31
    • 33750450544 scopus 로고    scopus 로고
    • Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection
    • Chackerian, A. A., Chen, S. J., Brodie, S. J. et al. 2006. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Infect. Immun. 74:6092.
    • (2006) Infect. Immun , vol.74 , pp. 6092
    • Chackerian, A.A.1    Chen, S.J.2    Brodie, S.J.3
  • 32
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish, C. L., Chen, Y., Blumenschein, W. M. et al. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201:233.
    • (2005) J. Exp. Med , vol.201 , pp. 233
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3
  • 33
    • 34547188748 scopus 로고    scopus 로고
    • Zhou, L. 2007. Ivanov, I. I., Spolski, R. et al. 2007. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8:967.
    • Zhou, L. 2007. Ivanov, I. I., Spolski, R. et al. 2007. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8:967.
  • 34
    • 0034125228 scopus 로고    scopus 로고
    • Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease
    • Korzenik, J. R. and Dieckgraefe, B. K. 2000. Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease. Dig. Dis. Sci. 45:1121.
    • (2000) Dig. Dis. Sci , vol.45 , pp. 1121
    • Korzenik, J.R.1    Dieckgraefe, B.K.2
  • 35
    • 0037048904 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor
    • Dieckgraefe, B. K. and Korzenik, J. R. 2002. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 360:1478.
    • (2002) Lancet , vol.360 , pp. 1478
    • Dieckgraefe, B.K.1    Korzenik, J.R.2
  • 36
    • 14644404938 scopus 로고    scopus 로고
    • An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease
    • Korzenik, J. R. and Dieckgraefe, B. K. 2005. An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease. Aliment. Pharmacol. Ther. 21:391.
    • (2005) Aliment. Pharmacol. Ther , vol.21 , pp. 391
    • Korzenik, J.R.1    Dieckgraefe, B.K.2
  • 37
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller, F, Florian, P., Bojarski, C. et al. 2005. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129:550.
    • (2005) Gastroenterology , vol.129 , pp. 550
    • Heller, F.1    Florian, P.2    Bojarski, C.3
  • 38
    • 0027492915 scopus 로고
    • Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-garnma or IL-10
    • de Waal Malefyt, R., Figdor, C. G., Huijbens, R. et al. 1993. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-garnma or IL-10. J. Immunol. 151:6370.
    • (1993) J. Immunol , vol.151 , pp. 6370
    • de Waal Malefyt, R.1    Figdor, C.G.2    Huijbens, R.3
  • 39
    • 0028930076 scopus 로고
    • Regulatory effects of IL-13 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis
    • Hart, P. H., Ahern, M. J., Smith, M. D. and Finlay-Jones, J. J. 1995. Regulatory effects of IL-13 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis. Clin. Exp. Immunol. 99:331.
    • (1995) Clin. Exp. Immunol , vol.99 , pp. 331
    • Hart, P.H.1    Ahern, M.J.2    Smith, M.D.3    Finlay-Jones, J.J.4
  • 40
    • 33750519061 scopus 로고    scopus 로고
    • 006. Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: Implications for hepatic anti-tumour immunity
    • Kelly, A. M., Golden-Mason, L., Traynor, O. et al. 006. Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: Implications for hepatic anti-tumour immunity. Cytokine 35:171.
    • Cytokine , vol.35 , pp. 171
    • Kelly, A.M.1    Golden-Mason, L.2    Traynor, O.3
  • 41
    • 0034090602 scopus 로고    scopus 로고
    • Anti-inflammatory cytokines
    • Opal, S. M. and DePalo, V A. 2000. Anti-inflammatory cytokines. Chest 117:1162.
    • (2000) Chest , vol.117 , pp. 1162
    • Opal, S.M.1    DePalo, V.A.2
  • 42
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    • Lee, C. G., Homer, R. J., Zhu, Z. et al. 2001. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J. Exp. Med. 194:809.
    • (2001) J. Exp. Med , vol.194 , pp. 809
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3
  • 43
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis
    • Kitani, A., Fuss, I., Nakamura, K., Kumaki, F., Usui, T. and Strober, W. 2003. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J. Exp. Med. 198:1179.
    • (2003) J. Exp. Med , vol.198 , pp. 1179
    • Kitani, A.1    Fuss, I.2    Nakamura, K.3    Kumaki, F.4    Usui, T.5    Strober, W.6
  • 44
    • 0032167603 scopus 로고    scopus 로고
    • The murine IL-13 receptor alpha 2: Molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1
    • Donaldson, D. D., Whitters, M. J., Fitz, L. J. et al. 1998. The murine IL-13 receptor alpha 2: Molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J. Immunol. 161:2317.
    • (1998) J. Immunol , vol.161 , pp. 2317
    • Donaldson, D.D.1    Whitters, M.J.2    Fitz, L.J.3
  • 45
    • 0031573220 scopus 로고    scopus 로고
    • Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
    • Wynn, T A., Morawetz, R., Scharton-Kersten, T. et al. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J. Immunol. 159:5014.
    • (1997) J. Immunol , vol.159 , pp. 5014
    • Wynn, T.A.1    Morawetz, R.2    Scharton-Kersten, T.3
  • 46
    • 34247853488 scopus 로고    scopus 로고
    • Drug insight: Different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?
    • Rigby, W. F. 2007. Drug insight: Different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior? Nat. Clin. Pract Rheumatol. 3:227.
    • (2007) Nat. Clin. Pract Rheumatol , vol.3 , pp. 227
    • Rigby, W.F.1
  • 47
    • 0033919790 scopus 로고    scopus 로고
    • Rescue of human T cells by interieukin-9 (IL-9) from IL-2 deprivation-induced apoptosis: Correlation with alpha subunit expression of the IL-9 receptor
    • Perdow-Hickman, S. and Salgame, P. 2000. Rescue of human T cells by interieukin-9 (IL-9) from IL-2 deprivation-induced apoptosis: correlation with alpha subunit expression of the IL-9 receptor. J. Interferon Cytokine Res. 20:603.
    • (2000) J. Interferon Cytokine Res , vol.20 , pp. 603
    • Perdow-Hickman, S.1    Salgame, P.2
  • 48
    • 0027717408 scopus 로고
    • Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice
    • Gessner, A., Blum, H. and Rollinghoff, M. 1993. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology 189:419.
    • (1993) Immunobiology , vol.189 , pp. 419
    • Gessner, A.1    Blum, H.2    Rollinghoff, M.3
  • 49
    • 0027197714 scopus 로고
    • Interleukin-9 potentiates the interieukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes
    • Dugas, B., Renauld, J. C., Pene, J. et al. 1993. Interleukin-9 potentiates the interieukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes. Eur. J. Immunol. 23:1687.
    • (1993) Eur. J. Immunol , vol.23 , pp. 1687
    • Dugas, B.1    Renauld, J.C.2    Pene, J.3
  • 50
    • 0033038648 scopus 로고    scopus 로고
    • IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice
    • Dong, Q., Louahed, J., Vink, A. et al. 1999. IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur. J. Immunol. 29:2130.
    • (1999) Eur. J. Immunol , vol.29 , pp. 2130
    • Dong, Q.1    Louahed, J.2    Vink, A.3
  • 51
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C. and Horak, I. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
    • (1993) Cell , vol.75 , pp. 253
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.