Are age-specific high serum IgE levels associated with worse symptomatology in children with atopic dermatitis?

International Journal of Dermatology

Volumn 46, Issue 12, 2007, Pages 1258-1262

  Hon, Kam Lun Ellis ^a   Lam, Man Ching Adrian ^a   Leung, Ting Fan ^a   Wong, Kin Yee ^a   Chow, Chung Mo ^a   Fok, Tai Fai ^a   Ng, Pak Cheung ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYTOKINE; EMOLLIENT AGENT; IMMUNOGLOBULIN E; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ADOLESCENT; ARTICLE; ATOPIC DERMATITIS; CHILD; CHINESE; CONFIDENCE INTERVAL; DIAGNOSTIC VALUE; DISEASE MARKER; DISEASE SEVERITY; EOSINOPHIL COUNT; FEMALE; HUMAN; HYPERIMMUNOGLOBULINEMIA; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SYMPTOMATOLOGY;

ADOLESCENT; AGE FACTORS; BIOLOGICAL MARKERS; CHEMOKINE CCL17; CHEMOKINE CCL27; CHILD; DERMATITIS, ATOPIC; EOSINOPHILS; FEMALE; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN E; MALE; PREDICTIVE VALUE OF TESTS; PRURITUS; ROC CURVE; SEVERITY OF ILLNESS INDEX; SKIN; SLEEP INITIATION AND MAINTENANCE DISORDERS; STATISTICS, NONPARAMETRIC;

EID: 37549042789     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2007.03407.x     Document Type: Article

References (17)

1. Laske N, Bunikowski R, Niggemann B. Extraordinarily high serum IgE levels and consequences for atopic phenotypes. Ann Allergy, Asthma, Immunol 2003; 91: 202-204.
2. Laske N, Niggemann B. Does the severity of atopic dermatitis correlate with serum IgE levels? Pediatr Allergy Immunol 2004; 15: 86-88.
3. Severity scoring of atopic dermatitis: The SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993; 186: 23-31.
4. Hon KL, Leung TF, Wong Y, et al. Subjective symptoms do not correlate well with disease extent or intensity in children with atopic dermatitis. Int J Dermatol 2006; 45: 728-730.
5. Hon KL, Leung TF, Ma KC, et al. Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Clin Exp Dermatol 2004; 29: 293-296.
6. Hon KL, Leung TF, Ma KC, et al. Urinary leukotriene E4 correlates with severity of atopic dermatitis in children. Clin Exp Dermatol 2004; 29: 277-281.
7. Leung TF, Ma KC, Hon KL, et al. Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children. Pediatr Allergy Immunol 2003; 14: 296-301.
8. Hon KL, Leung TF, Ma KC, et al. Serum concentration of IL-18 correlates with disease extent in young children with atopic dermatitis. Pediatr Dermatol 2004; 21: 619-622.
9. Hanifin JM, Rajka RG. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 2: 44-47.
10. Kunz B, Oranje AP, Labreze L, et al. Clinical validation and guidelines for the SCORAD index: Consensus report of the European task force on atopic dermatitis. Dermatology 1997; 195: 10-19.
11. Kulig M, Tacke U, Forster J, et al. Serum IgE levels during the first 6.years of life. J Pediatr 1999; 134: 453-458.
12. Wittig HJ, Belloit J, De FI, et al. Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease. J Allergy Clin Immunol 1980; 66: 305-313.
13. Hetman S, Kivity S, Greif J, et al. IgE values in the allergic and healthy Israeli population. Ann Allergy 1988; 61: 123-128.
14. Neuber K, Steinrucke K, Ring J. Staphylococcal enterotoxin B affects in vitro IgE synthesis, interferon-gamma, interleukin-4 and interleukin-5 production in atopic eczema. Int Arch Allergy Immunol 1995; 107: 179-182.
15. Leung DY, Harbeck R, Bina P, et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis: evidence for a new group of allergens. J Clin Invest 1993; 92: 1374-1380.
16. Zollner TM, Wichelhaus TA, Hartung A, et al. Colonization with superantigen-producing Staphylococcus aureus is associated with increased severity of atopic dermatitis. Clin Exp Allergy 2000; 30: 994-1000.
17. Hon KL, Lam MCA, Leung TF, et. al. Clinical features associated with nasal Staphylococcus aureus colonization in children with moderate to severe atopic dermatitis. Ann Acad Med Sing 2005; 34: 602-605.