Altered morphology, nuclear stability and adhesion of highly metastatic derivatives of osteoblast-like SAOS-2 osteosarcoma cells

Anticancer Research

Volumn 27, Issue 6 B, 2007, Pages 3973-3979

  Muff, Roman ^a   Nigg, Natalie ^a   Gruber, Philipp ^a   Walters, Denise ^a   Born, Walter ^a   Fuchs, Bruno ^a  

^a BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Adhesion; Alkaline phosphatase; Cytotoxicity; Metastasis; Osteosarcoma

Indexed keywords

ALKALINE PHOSPHATASE; CISPLATIN; CYCLIC AMP; DOXORUBICIN; ETOPOSIDE; PARATHYROID HORMONE;

ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL MIGRATION; CELL NUCLEUS; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VIVO STUDY; METASTASIS; OSTEOBLAST; OSTEOSARCOMA CELL; PHENOTYPE; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; BONE NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL NUCLEUS; CISPLATIN; CYCLIC AMP; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; NEOPLASM INVASIVENESS; OSTEOBLASTS; OSTEOSARCOMA;

EID: 37549033087     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Bacci G, Longhi A, Fagioli F, Briccoli A, Versari M and Picci P: Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy. Eur J Cancer 41: 2836-2845, 2005.
2. Bacci G, Longhi A, Ferrari S, Lari S, Manfrini M, Donati D, Forni C and Versari M: Prognostic significance of serum alkaline phosphatase in osteosarcoma of the extremity treated with neoadjuvant chemotherapy: recent experience at Rizzoli Institute. Oncol Rep 9: 171-175, 2002.
3. Mialou V, Philip T, Kalifa C, Perol D, Gentet JC, Marec-Berard P, Pacquement H, Chastagner P, Defaschelles AS and Hartmann O: Metastatic osteosarcoma at diagnosis: prognostic factors and long-term outcome-the French pediatric experience. Cancer 104: 1100-1109, 2005.
4. Manoso MW, Healey JH, Boland PJ, Athanasian EA, Maki RG, Huvos AG and Morris CD: De novo osteogenic sarcoma in patients older than forty: benefit of multimodality therapy. Clin Orthop Relat Res 438: 110-115, 2005.
5. Bramer JA, Abudu AA, Tillman RM, Carter SR, Sumathi VP and Grimer RJ: Pre- and post-chemotherapy alkaline phosphatase levels as prognostic indicators in adults with localised osteosarcoma. Eur J Cancer 41: 2846-2852, 2005.
6. Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A and Picci P: Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer 106: 1154-1161, 2006.
7. Jia S-F, Worth LL and Kleinerman ES: A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies. Clin Exp Metastasis 17: 501-506, 1999.
8. Farley JR, Hall SL, Herring S, Tarbaux NM, Matsuyama T and Wergedal JE: Skeletal alkaline phosphatase specific activity is an index of the osteoblastic phenotype in subpopulations of the human osteosarcoma cell line SaOS-2. Metabolism 40: 664-671, 1991.
9. Moran J, Hunziker W and Fischer JA: Calcitonin and calcium ionophores: cyclic AMP responses in cells of a human lymphoid line. Proc Natl Acad Sci USA 75: 3984-3988, 1978.
10. Forrest SM, Ng KW, Findlay DM, Michelangeli VP, Livesey SA, Partridge NC, Zajac JD and Martin TJ: Characterization of an osteoblast-like clonal cell line which responds to both parathyroid hormone and calcitonin. Calcif Tissue Int 37: 51-56, 1985.
11. Kimura K, Nakano T, Park Y-B, Tani M, Tsuda H, Beppu Y, Moriya H and Yokota J: Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma. Clin Exp Metastasis 19: 477, 2002.
12. Manara MC, Baldini N, Serra M, Lollini PL, De Giovanni C, Vaccari M, Argnani A, Benini S, Maurici D, Picci P and Scotlandi K: Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. Bone 26: 215-220, 2000.
13. Duan X, Jia SF, Zhou Z, Langley RR, Bolontrade MF and Kleinerman ES: Association of avβ3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells. Clin Exp Metastasis 21: 747-753, 2004.
14. Pasquini GM, Davey RA, Ho PW, Michelangeli VP, Grill V, Kaczmarczyk SJ and Zajac JD: Local secretion of parathyroid hormone-related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition. Bone 31: 598-605, 2002.
15. Rodan SB, Wesolowski G, Ianacone J, Thiede MA and Rodan GA: Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor. J Endocrinol 122: 219-227, 1989.
16. Lohse CM, Blute ML, Zincke H, Weaver AL and Cheville JC: Comparison of standardized and nonstandardized nuclear grade of renal cell carcinoma to predict outcome among 2,042 patients. Am J Clin Pathol 118: 877-886, 2002.
17. Leleu X, Genevieve F, Guieze R, Duhamel A, Andrieux J, Berthon C, Godon A, Prat-Lesaffre S, Depil S, Lai JL, Facon T and Zandecki M: Irregular nuclear shape of bone marrow plasma cells defines a multiple myeloma subgroup related to hypodiploidy and to short survival. Leuk Res 29: 665-671, 2005.
18. Fischer AH, Bardarov S Jr and Jiang Z: Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancer. J Cell Biochem 91: 170-184, 2004.
19. Liu CQ, Sasaki H, Fahey MT, Sakamoto A, Sato S and Tanaka T: Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. Br J Cancer 79: 1736-1741, 1999.
20. Kobayashi Y, Yokose T, Kawamura K, Iwasaki S, Murata Y, Onuma S, Hasebe T, Nagai K, Sasaki S and Ochiai A: Cytologic factors associated with prognosis in patients with peripheral adenocarcinoma of the lung measuring 3 cm or less in greatest dimension. Cancer 105: 44-51, 2005.
21. Fan F, Namiq AL, Tawfik OW and Thomas PA: Proposed prognostic score for breast carcinoma on fine needle aspiration based on nuclear grade, cellular dyscohesion and bare atypical nuclei. Diagn Cytopathol 34: 542-546, 2006.
22. Domanski HA, Akerman M, Rissler P and Gustafson P: Fine-needle aspiration of soft tissue leiomyosarcoma: an analysis of the most common cytologic findings and the value of ancillary techniques. Diagn Cytopathol 34: 597-604, 2006.
23. Li Y, Tang ZY, Ye SL, Liu YK, Chen J, Xue Q, Chen J, Gao DM and Bao WH: Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol 7: 630-636, 2001.
24. Martin TA, Watkins G and Jiang WG: KiSS-1 expression in human breast cancer. Clin Exp Metastasis 22: 503-511, 2005.
25. Murata K, Miyoshi E, Ihara S, Noura S, Kameyama M, Ishikawa O, Doki Y, Yamada T, Ohigashi H, Sasaki Y, Higashiyama M, Tarui T, Takada Y, Kannagi R, Taniguchi N and Imaoka S: Attachment of human colon cancer cells to vascular endothelium is enhanced by N-acetylglucosaminyltransferase V. Oncology 66: 492-501, 2004.