The validity of mitochondrial dehydrogenases as antimalarial drug targets

Trends in Parasitology

Volumn 24, Issue 1, 2008, Pages 8-9

  Vaidya, Akhil B ^a   Painter, Heather J ^a   Morrisey, Joanne M ^a   Mather, Michael W ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMALARIAL AGENT; DIHYDROOROTATE DEHYDROGENASE; DIPHENYLIODONIUM SALT; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE;

DRUG TARGETING; ENZYMATIC ASSAY; ESCHERICHIA COLI; GENE EXPRESSION; GENETIC RESISTANCE; GROWTH INHIBITION; LETTER; MALARIA; MITOCHONDRION; NONHUMAN; PLASMODIUM FALCIPARUM; RESPIRATORY CHAIN;

ANIMALS; ANTIMALARIALS; DRUG DELIVERY SYSTEMS; MALARIA; MITOCHONDRIA; OXIDOREDUCTASES; PLASMODIUM;

EID: 37549014901     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2007.10.005     Document Type: Letter

References (9)

1. Vaidya A.B. Mitochondrial physiology as a target for atovaquone and other antimalarials. In: Sherman I.W. (Ed). Malaria: Parasite Biology, Pathogenesis, and Protection (1998), ASM Press 355-368
2. Fisher N., et al. The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle. Trends Parasitol. 23 (2007) 305-310
3. Vaidya A.B., and Mather M.W. A post-genomic view of the mitochondrion in malaria parasites. Curr. Top. Microbiol. Immunol. 295 (2005) 233-250
4. Gardner M.J., et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419 (2002) 498-511
5. Mather M.W., et al. Mitochondrial drug targets in apicomplexan parasites. Curr. Drug Targets 8 (2007) 49-60
6. Painter H.J., et al. Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446 (2007) 88-91
7. Gutteridge W.E., et al. Conversion of dihydroorotate to orotate in parasitic protozoa. Biochim. Biophys. Acta 582 (1979) 390-401
8. Fry M., and Beesley J.E. Mitochondria of mammalian Plasmodium spp. Parasitology 102 (1991) 17-26
9. Biagini G.A., et al. Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria. Antimicrob. Agents Chemother. 50 (2006) 1841-1851