RP-HPLC study of resveratrol derivative (BTM-0512) in rat plasma and tissue distribution

Yaoxue Xuebao

Volumn 42, Issue 11, 2007, Pages 1183-1188

  Ma, Ning ^a,b   Liu, Wen Ying ^a   Li, Huan De ^b   Jiang, Xin Yu ^c   Zhang, Bi Kui ^b   Zhu, Rong Hua ^b   Wang, Feng ^b   Xie, Yue Liang ^c   Zhou, Xiao Qian ^d   Wu, Xue ^c   Xiang, Da Xiong ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d HUNAN NORMAL UNIVERSITY   (China)

Author keywords

(E) 3,5,4 trimethoxystilbene; HPLC; Resveratrol

Indexed keywords

3,4',5 TRIMETHOXYSTILBENE; 3,4',5-TRIMETHOXYSTILBENE; ANGIOGENESIS INHIBITOR; ANTIALLERGIC AGENT; ANTINEOPLASTIC AGENT; STILBENE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METHODOLOGY; RAT; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; ULTRAVIOLET SPECTROPHOTOMETRY;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-ALLERGIC AGENTS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; STILBENES; TISSUE DISTRIBUTION;

EID: 37549014577     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Frémont L. Minireview: biological effects of resveratrol [J]. Life Sci. 2000,66:663-673.
2. Cao Y, Cao R, Brakenhielm E. Antiangiogenic mechanisms of diet-derived polyphenols [J]. J Nutr Biochem, 2002,13:380-390.
3. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes [J]. Science, 1997,275:218-220.
4. Belleri M, Ribatti D, Nicoli S, et al. Antiangiogenic and vascular-targeting activity of the microtubule destabilizing frans-resveratrol derivative 3, 5, 4′trimethoxystilbene [J]. Mol Pharmacol, 2005,67:1451-1459.
5. L5] Chabert P, Fougerousse A, Brouillard R. Anti-mitotic properties of resveratrol analog (Z ) -3, 5, 4′-trimethoxystilbene [J]. Biofactors, 2006,27:37-46.
6. Cushman M, Nagarathnam D, Gopal D, et al. Synthesis and evaluation of analogues of (Z )-1-(4-methoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) ethene as potential cytotoxic and antimitotic agents [J]. J Med Chem, 1992,35:2293-2306.
7. Simoni D, Roberti M, Invidiata FP, et al. Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism [J]. Bioorg Med Chem Lett, 2006,16;3245-3248.
8. Matsuda H, Tewtrakul S, Morikawa T, et al. Antiallergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-a and IL-4 in RBL-2H3 cells [J]. Bioorg Med Chem, 2004,12:4871-4876.
9. Kim S, Ko H, Park JE, et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors [J]. J Med Chem, 2002,45:160-164.
10. Pettit GR, Grealish MP, Jung MK, et al. Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate [J]. J Med Chem, 2002, 45:2534-2542.
11. Sale S, Verschoyle RD, Boocock D, et al. Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3, 4, 5, 4′-tetramethoxystilbene [J]. Br J Cancer, 2004,90:736-744.
12. Schneider Y, Chabert P, Stutzmann J, et al. Resveratrol analog (Z) -3, 5, 4′-trimethoxystilbene is a potent antimitotic drug inhibiting tubulin polymerization [J]. Int J Cancer, 2003,107:189-196.
13. Thakkar K, Geahlen RL, Cushman M. Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol [J]. J Med Chem, 1993,36:2950-2955.
14. Azzena U, Dettori G, Idini MV, et al. Regioselective reductive demethoxylation of 3, 4, 5-trimethoxystilbenes [J]. Tetrahedron, 2003,59:7961-7966.
15. Cardile V, Lombarde L, Spatafora C, et al. Chemoenzymatic synthesis and cell-growth inhibition activity of resveratrol analogues [J]. Bioorg Chem, 2005,33:22-33.
16. Farines V, Monje MC, Telo JP, et al. Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors [J]. Anal Chim Acta, 2004,513:103-111.
17. Vitrac X, Desmouliere A, Brouillaud B, et al. Distribution of [14C ] -trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration [J]. Life Sci, 2003,72:2219-2233.