Effects of initial eye position on saccade-related behavior of abducens nucleus neurons in the primate

Journal of Neurophysiology

Volumn 98, Issue 6, 2007, Pages 3581-3599

  Ling, Leo ^a   Fuchs, Albert ^a   Siebold, Christoph ^a   Dean, Paul ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABDUCENS NERVE; ABDUCENS NUCLEUS; ANIMAL BEHAVIOR; ARTICLE; EXTRAOCULAR MUSCLE; EYE MOVEMENT CONTROL; EYE POSITION; LINEAR REGRESSION ANALYSIS; MOTONEURON; NERVE CELL; NONHUMAN; PRIMATE; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT;

ABDUCENS NERVE; ANIMALS; BEHAVIOR, ANIMAL; DATA INTERPRETATION, STATISTICAL; ELECTROMYOGRAPHY; ELECTROPHYSIOLOGY; EYE MOVEMENTS; FIXATION, OCULAR; MACACA MULATTA; MICROELECTRODES; MODELS, NEUROLOGICAL; MOTOR NEURONS; OCULOMOTOR MUSCLES; SACCADES;

EID: 37549013751     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00992.2007     Document Type: Article

References (48)

1. Abel L, Dell'ossa L, Daroff R, Parker L. Saccades in extremes of lateral gaze. Invest Ophthalmol Vis Sci 18: 324-327, 1979.
2. Collewijn H, Erklens C, Steinman R. Binocular co-ordination of human horizontal saccadic eye movements. J Physiol 404: 157-182, 1988.
3. Collins C, O'Meara D, Scott A. Muscle tension during unrestrained human eye movements. J Physiol 245: 351-369, 1975.
4. Collins CC. The human oculomotor control system. In: Basic Mechanisms of Ocular Motility and Their Clinical Implications, edited by Lennerstrand G, Bach-y-Rita P. Oxford, UK: Pergamon Press, 1975, p. 145-180.
5. Cullen KE, Guitton D. Analysis of primate IBN spike trains using system identification techniques. I. Relationship to eye movement dynamics during head-fixed saccades. J Neurophysiol 78: 3259-3282, 1997.
6. Dean P. Motor unit recruitment in a distributed model of extraocular muscle. J Neurophysiol 76: 727-742, 1996.
7. Dean P, Porrill J, Warren PA. Optimality of static force control by horizontal eye muscles: a test of the minimum norm rule. J Neurophysiol 81: 735-757, 1999.
8. Eggert T, Mezger F, Robinson F, Straube A. Orbital position dependency is different for the gain of externally and internally triggered saccades. Neuroreport 10: 2665-2670, 1999.
9. Escudero M, De La Cruz RR, Delgado-García JM. A physiological study of vestibular and prepositus hypoglossi neurones projecting to the abducens nucleus in the alert cat. J Physiol 458: 539-560, 1992.
10. Evinger LC, Fuchs AF, Baker R. Bilateral lesions of the medial longitudinal fasciculus in monkeys: effects on the horizontal and vertical components of voluntary and vestibular induced eye movements. Exp Brain Res 28: 1-20, 1977.
11. Frost D, Pöppel E. Different programming modes of human saccadic eye movements as a function of stimulus eccentricity: indications of a functional subdivision of the visual field. Biol Cybern 23: 39-48, 1976.
12. Fuchs AF, Luschei ES. Firing patterns of abducens neurons of alert monkeys in relationship to horizontal eye movement. J Neurophysiol 33: 382-392, 1970.
13. Fuchs AF, Luschei ES. The activity of single trochlear nerve fibers during eye movements in the alert monkey. Exp Brain Res 13: 78-89, 1971.
14. Fuchs AF, Robinson DA. A method for measuring horizontal and vertical eye movement chronically in the monkey. J Appl Physiol 21: 1068-1070, 1966.
15. Fuchs AF, Scudder CA, Kaneko CRS. Discharge patterns and recruitment order of identified motoneurons and internuclear neurons in the monkey abducens nucleus. J Neurophysiol 60: 1874-1895, 1988.
16. Goldberg SJ, Meredith MA, Shall MS. Extraocular motor units and wholemuscle responses in the lateral rectus muscle of the squirrel monkey. J Neurosci 18: 10629-10639, 1998.
17. Goldstein H. The Neural Encoding of Saccades in the Rhesus Monkey (PhD dissertation). Baltimore, MD: The Johns Hopkins Univ., 1983.
18. Goldstein H, Robinson DA. Position dependence of saccadic signals on oculomotor neurons. In: Proceedings of the Mechanics of Strabismus Symposium. San Francisco, CA: Smith-Kettlewell Eye Research Institute, 1992, p. 171-186.
19. Hannaford B, Stark L. Roles of the elements of the triphasic control signal. Exp Neurol 90: 619-634, 1985.
20. Hazel TR, Sklavos SG, Dean P. Estimation of premotor synaptic drives to simulated abducens motoneurons for control of eye position. Exp Brain Res 146: 184-196, 2002.
21. Henneman E, Mendell LM. Functional organization of motoneuron pool and its inputs. In: Handbook of Physiology. The Nervous System. Motor Control. Bethesda, MD: Am. Physiol. Soc., 1981, sect. 1, vol. II, pt. 1, p. 423-507.
22. Hyde J. Some characteristics of voluntary human ocular movements in the horizontal plane. Am J Ophthalmol 48: 88-94, 1959.
23. Inchingolo P, Spanio, M, Bianchi M. The characteristic peak velocity-mean velocity of saccadic eye movements in man. In: Eye Movements: From Physiology to Cognition, edited by O'Regan J, Lèvy-Schoen A. Amsterdam: Elsevier Science/North-Holland, 1987, p. 17-26.
24. Jürgens R, Becker W, Kornhuber H. Natural and drug-induced variations of velocity and duration of human saccadic eye movements: evidence for a control of the neural pulse generator by local feedback. Biol Cybern 39: 87-96, 1981.
25. Keller EL. Participation of medial pontine reticular formation in eye movement generation in monkey. J Neurophysiol 37: 316-332, 1974.
26. Keller EL, Robinson DA. Absence of a stretch reflex in extraocular muscles of the monkey. J Neurophysiol 34: 908-919, 1971.
27. Koene A, Erklens C. Cause of kinematic differences during centrifugal and centripetal saccades. Vision Res 42: 1797-1808, 2002.
28. Langer T, Fuchs AF, Scudder CA, Chubb MC. Afferents to the flocculus of the cerebellum in the rhesus macaque as revealed by retrograde transport of horseradish peroxidase. J Comp Neurol 235: 1-25, 1985.
29. Lennerstrand G, Schiavi C, Tian S, Benassi M, Campos EC. Isometric force measured in human horizontal eye muscles attached to or detached from the globe. Graefes Arch Clin Exp Ophthalmol 244: 539-544, 2006.
30. McClung JR, Shall MS, Goldberg SJ. Motoneurons of the lateral and medial rectus extraocular muscles in squirrel monkey and cat. Cells Tissues Organs 168: 220-227, 2001.
31. McFarland JL, Fuchs AF. Role of the nucleus prepositus hypoglossi and adjacent medial vestibular nucleus in the control of horizontal eye movements in behaving primates. J Neurophysiol 68: 319-332, 1992.
32. Miller J, Robins D. Extraocular muscle forces in alert monkeys. Vision Res 32: 1099-1113, 1992.
33. Pélisson D, Prablanc C. Kinematics of centrifugal and centripetal saccadic eye movements in man. Vision Res 28: 87-94, 1988.
34. Phillips JO, Ling L, Fuchs AF, Siebold C, Plorde J. Rapid horizontal gaze movement in the monkey. J Neurophysiol 73: 1632-1652, 1995.
35. Robinson DA. A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Trans Biomed Electron BME-10: 137-145, 1963.
36. Robinson DA. Oculomotor unit behavior in the monkey. J Neurophysiol 33: 393-404, 1970.
37. Robinson DA. Oculomotor control signals. In: Basic Mechanisms of Ocular Motility and Their Clinical Implications, edited by Lennerstrand G, Bach-y-Rita P. Oxford, UK: Pergamon, 1975, p. 337-374.
38. Rottach K, Das V, Wohlgemuth W, Zivotofsky A, Leigh R. Properties of horizontal saccades accompanied by blink. J Neurophysiol 79: 2895-2902, 1998.
39. Schiller P. The discharge characteristics of single units in the oculomotor and abducens nuclei of the unanesthetized monkey. Exp Brain Res 10: 347-362, 1970.
40. Scudder C, Fuchs AF, Langer T. Characteristics and functional identification of saccadic inhibitory burst neurons in the alert monkey. J Neurophysiol 59: 1430-1454, 1988.
41. Scudder CA, Fuchs AF. Physiological and behavioral identification of secondary neurons mediating the horizontal vestibulo-ocular reflex in trained rhesus monkeys. J Neurophysiol 68: 244-264, 1992.
42. Shall M, Dimitrova D, Goldberg S. Extraocular motor unit and whole-muscle contractile properties in the squirrel monkey. Exp Brain Res 151: 338-345, 2003.
43. Siebold C, Ling L, Fuchs AF. Saccadic bursts of abducens neurons do not fully compensate for orbital nonlinearities. Soc Neurosci Abstr 18: 700, 1992.
44. Strassman A, Highstein SM, McCrea RA. Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. I. Excitatory burst neurons. J Comp Neurol 249: 337-357, 1986a.
45. Strassman A, Highstein SM, McCrea RA. Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. II. Inhibitory burst neurons. J Comp Neurol 249: 358-380, 1986b.
46. Sylvestre P, Cullen K. Quantitative analysis of abducens neuron discharge dynamics during saccadic and slow eye movements. J Neurophysiol 82: 2612-2632, 1999.
47. Van Gisbergen J, Robinson DA, Gielen SA. A quantitative analysis of generation of saccadic eye movements by burst neurons. J Neurophysiol 45: 417-442, 1981.
48. Wong AMF, McReelis K, Sharpe JA. Saccade dynamics in peripheral vs. central sixth nerve palsies. Neurology 66: 1390-1398, 2006.