Too old for IVF: Are we discriminating against older women?

Journal of Assisted Reproduction and Genetics

Volumn 24, Issue 12, 2007, Pages 639-644

  Gleicher, Norbert ^a,d,e,f   Weghofer, Andrea ^b,d   Barad, David ^c,d,e,f  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d CENTER FOR HUMAN REPRODUCTION   (United States)

^e Foundation for Reproductive Medicine   (United States)

^f Foundation for Reproductive Medicine   (United States)

Author keywords

Age; Diminished ovarian reserve; Embryos; Follicle stimulating hormone (FSH); In vitro fertilization (IVF); Oocytes; Premature ovarian aging

Indexed keywords

FOLLITROPIN;

CLINICAL PRACTICE; CONFERENCE PAPER; FERTILITY; FERTILIZATION IN VITRO; FOLLITROPIN BLOOD LEVEL; HEALTH CARE NEED; HEALTH INSURANCE; HUMAN; POPULATION DYNAMICS; PRIORITY JOURNAL; REPRODUCTIVE HEALTH; UNITED STATES;

ADULT; AGING; COST-BENEFIT ANALYSIS; FEMALE; FERTILIZATION IN VITRO; HEALTH SERVICES ACCESSIBILITY; HUMANS; MATERNAL AGE; PHYSICIAN'S PRACTICE PATTERNS; PREGNANCY; PREGNANCY RATE; PREJUDICE; TREATMENT OUTCOME;

EID: 37549007253     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10815-007-9182-1     Document Type: Conference Paper

References (31)

1. Wright VC, Chang J, Jeng G, Chen M, Macaluso M. Assisted reproductive technology surveillance-United States, 2004. MMWR Surveill Summ 2007;56(6):1-22.
2. Hamilton BE, Martin JA, Sutton PD. Births: preliminary data for 2003. Natl Vital Stat Rep 2004;53(9):1-17.
3. Hamilton BE, Martin JA, Sutton PD. Births: preliminary data for 2002. Natl Vital Stat Rep 2003;51(11):1-20.
4. Gleicher N, Barad D. Unexplained infertility: does it really exist? Hum Reprod 2006;21(8):1951-5.
5. Assisted Reproductive Technology Success rates. National Summary and Fertility Clinic Reports. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention December 2006.
6. Faddy MJ. Follicle dynamics during ovarian ageing. Mol Cell Endocrinol 2000;163(1-2):43-8.
7. Faddy MJ, Gosden RG. A mathematical model of follicle dynamics in the human ovary. Hum Reprod 1995;10(4):770-5.
8. ASRM. Aging and infertility in women: a committee opinion. Fertil Steril 2002;78(1):215-9.
9. Scott RT Jr. Diminished ovarian reserve and access to care. Fertil Steril 2004;81(6):1489-92. discussion 496-7.
10. Barad DH, Weghofer A, Gleicher N. Age-specific levels for basal follicle-stimulating hormone assessment of ovarian function. Obstet Gynecol 2007;109(6):1404-10.
11. Frattarelli JL, Levi AJ, Miller BT, Segars JH. A prospective assessment of the predictive value of basal antral follicles in in vitro fertilization cycles. Fertil Steril 2003;80(2):350-5.
12. van Rooij IA, Broekmans FJ, te Velde ER, et al. Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve. Hum Reprod 2002;17(12):3065-71.
13. Chuang CC, Chen CD, Chao KH, Chen SU, Ho HN, Yang YS. Age is a better predictor of pregnancy potential than basal follicle-stimulating hormone levels in women undergoing in vitro fertilization. Fertil Steril 2003;79(1):63-8.
14. van Rooij IA, Bancsi LF, Broekmans FJ, Looman CW, Habbema JD, te Velde ER. Women older than 40 years of age and those with elevated follicle-stimulating hormone levels differ in poor response rate and embryo quality in in vitro fertilization. Fertil Steril 2003;79(3):482-8.
15. van Rooij IA, de Jong E, Broekmans FJ, Looman CW, Habbema JD, te Velde ER. High follicle-stimulating hormone levels should not necessarily lead to the exclusion of subfertile patients from treatment. Fertil Steril 2004;81(6):1478-85.
16. Wolff EF, Taylor HS. Value of the day 3 follicle-stimulating hormone measurement. Fertil Steril 2004;81(6):1486-8. discussion 496-7.
17. Toner JP. Modest follicle-stimulating hormone elevations in younger women: warn but don't disqualify. Fertil Steril 2004;81(6):1493-5. discussion 496-7.
18. Spandorfer SD, Bendikson K, Dragisic K, Schattman G, Davis OK, Rosenwaks Z. Outcome of in vitro fertilization in women 45 years and older who use autologous oocytes. Fertil Steril 2007;87(1):74-6.
19. Nikolaou D, Templeton A. Early ovarian ageing: a hypothesis. Detection and clinical relevance. Hum Reprod 2003;18(6):1137-9.
20. Gleicher N, Barad D. "Ovarian age-based" stimulation of young women with diminished ovarian reserve results in excellent pregnancy rates with in vitro fertilization. Fertil Steril 2006;86(6):1621-5.
21. Weghofer A, Barad D, Li J, Gleicher N. Aneuploidy rates in embryos from women with prematurely declining ovarian function: a pilot study. Fertil Steril 2007;88(1):90-4.
22. Hull MG, Fleming CF, Hughes AO, McDermott A. The age-related decline in female fecundity: a quantitative controlled study of implanting capacity and survival of individual embryos after in vitro fertilization. Fertil Steril 1996;65(4):783-90.
23. Marcus SF, Brinsden PR. In-vitro fertilization and embryo transfer in women aged 40 years and over. Hum Reprod Update 1996;2(6):459-68.
24. Barad D, Gleicher N. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum Reprod 2006;21(11):2845-9.
25. Brill H, Barad DH, Gleicher N. O-289: Dehydroepiandrosterone (DHEA) supplementation and pregnancy outcome: effect on pregnancy rate and speed of conception. Fertil Steril 2006;86(3, Supplement 1):S124-S5.
26. Thornton K, Ryley D, Alper M, Ezcurra D. 2):S141. S. IVF outcome in women over age 40 years with elevated cycle day 3 FSH (≥10 mIU/mL). Fertil Steril 2006;86(Suppl 2):S141.
27. Hernandez J, Sanabria V, Chinea E, Palumbo A. Reproductive outcome in women 40 and older undergoing in vitro fertilization (IVF). Fertil Steril 2006;86(Suppl 2):S166-7.
28. Watt AH, Legedza AT, Ginsburg ES, Barbieri RL, Clarke RN, Hornstein MD. The prognostic value of age and follicle-stimulating hormone levels in women over forty years of age undergoing in vitro fertilization. J Assist Reprod Genet 2000;17(5):264-8.
29. Osmanagaoglu K, Tournaye H, Kolibianakis E, Camus M, Van Steirteghem A, Devroey P. Cumulative delivery rates after ICSI in women aged >37 years. Hum Reprod 2002;17(4):940-4.
30. Awonuga A, Merhi Z, Grazi R. Intrauterine inseminations versus in vitro fertilization in infertile women 40 years and older. Fertil Steril 2006;86(Suppl 2):S143.
31. Gleicher N, Barad D. The relative myth of elective single embryo transfer. Hum Reprod 2006;21(6):1337-44.