메뉴 건너뛰기




Volumn 132, Issue 6, 2007, Pages 1898-1905

Low-molecular-weight heparin inhibits hypoxic pulmonary hypertension and vascular remodeling in guinea pigs

Author keywords

Dalteparin; Enoxaparin; Hypoxia; Low molecular weight heparin

Indexed keywords

ARDEPARIN; CERTOPARIN; DALTEPARIN; ENOXAPARIN; LOW MOLECULAR WEIGHT HEPARIN; PARNAPARIN; PROTEIN P27;

EID: 37549005172     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.06-0941     Document Type: Article
Times cited : (15)

References (44)
  • 1
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med 2004; 351:1655-1665
    • (2004) N Engl J Med , vol.351 , pp. 1655-1665
    • Farber, H.W.1    Loscalzo, J.2
  • 2
    • 0028519806 scopus 로고
    • Hypoxia and endothelial-smooth muscle cell interactions in the lung
    • Kourembanas S, Bernfield M. Hypoxia and endothelial-smooth muscle cell interactions in the lung. Am J Respir Cell Mol Biol 1994; 11:373-374
    • (1994) Am J Respir Cell Mol Biol , vol.11 , pp. 373-374
    • Kourembanas, S.1    Bernfield, M.2
  • 3
    • 0025342724 scopus 로고
    • Pulmonary hypertension due to chronic hypoxia
    • Peacock A. Pulmonary hypertension due to chronic hypoxia. BMJ 1990; 300:763
    • (1990) BMJ , vol.300 , pp. 763
    • Peacock, A.1
  • 4
    • 0024414987 scopus 로고
    • Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium
    • Tozzi CA, Poiani GJ, Harangozo AM, et al. Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium. J Clin Invest 1989; 84:1005-1012
    • (1989) J Clin Invest , vol.84 , pp. 1005-1012
    • Tozzi, C.A.1    Poiani, G.J.2    Harangozo, A.M.3
  • 5
    • 0024510073 scopus 로고
    • Acute and chronic hypoxic pulmonary hypertension in guinea pigs
    • Thompson BT, Hassoun PM, Kradin RL, et al. Acute and chronic hypoxic pulmonary hypertension in guinea pigs. J Appl Physiol 1989; 66:920-928
    • (1989) J Appl Physiol , vol.66 , pp. 920-928
    • Thompson, B.T.1    Hassoun, P.M.2    Kradin, R.L.3
  • 6
    • 0030782624 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary hypertension in an optimized environment for the guinea pig
    • Bochnowicz S, Osborn RR, Hay DW, et al. Hypoxia-induced pulmonary hypertension in an optimized environment for the guinea pig. Lab Anim 1997; 31:347-356
    • (1997) Lab Anim , vol.31 , pp. 347-356
    • Bochnowicz, S.1    Osborn, R.R.2    Hay, D.W.3
  • 7
    • 0024537365 scopus 로고
    • Effect of heparin and warfarin on chronic hypoxic pulmonary hypertension and vascular remodeling in the guinea pig
    • Hassoun PM, Thompson BT, Steigman D, et al. Effect of heparin and warfarin on chronic hypoxic pulmonary hypertension and vascular remodeling in the guinea pig. Am Rev Respir Dis 1989; 139:763-768
    • (1989) Am Rev Respir Dis , vol.139 , pp. 763-768
    • Hassoun, P.M.1    Thompson, B.T.2    Steigman, D.3
  • 8
    • 0023002454 scopus 로고
    • Glomerular endothelial cells secrete a heparin like inhibitor and a peptide stimulator of mesangial cell proliferation
    • Castellot JJ Jr, Hoover RL, Karnovsky MJ. Glomerular endothelial cells secrete a heparin like inhibitor and a peptide stimulator of mesangial cell proliferation. Am J Pathol 1986; 125:493-500
    • (1986) Am J Pathol , vol.125 , pp. 493-500
    • Castellot Jr, J.J.1    Hoover, R.L.2    Karnovsky, M.J.3
  • 9
    • 0028200639 scopus 로고
    • Inhibition of hypoxic pulmonary hypertension by heparins of differing in vitro antiproliferative potency
    • Thompson BT, Spence CR, Janssens SP, et al. Inhibition of hypoxic pulmonary hypertension by heparins of differing in vitro antiproliferative potency. Am J Respir Crit Care Med 1994; 149:1512-1517
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 1512-1517
    • Thompson, B.T.1    Spence, C.R.2    Janssens, S.P.3
  • 10
    • 0037470456 scopus 로고    scopus 로고
    • Heparin inhibits SMC growth in the presence of human and fetal bovine serum
    • Cindhuchao N, Quinn DA, Garg HG, et al. Heparin inhibits SMC growth in the presence of human and fetal bovine serum. Biochem Biophys Res Commun 2003; 302:84-88
    • (2003) Biochem Biophys Res Commun , vol.302 , pp. 84-88
    • Cindhuchao, N.1    Quinn, D.A.2    Garg, H.G.3
  • 11
    • 27644564685 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice
    • Yu L, Quinn DA, Garg HG, et al. Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice. Circ Res 2005; 97:937-945
    • (2005) Circ Res , vol.97 , pp. 937-945
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3
  • 12
    • 0032745131 scopus 로고    scopus 로고
    • Production and chemical processing of low molecular weight heparins
    • Linhardt RJ, Gunay NS. Production and chemical processing of low molecular weight heparins. Semin Thromb Haemost 1999; 25(suppl 3):5-16
    • (1999) Semin Thromb Haemost , vol.25 , Issue.SUPPL. 3 , pp. 5-16
    • Linhardt, R.J.1    Gunay, N.S.2
  • 13
    • 0032042304 scopus 로고    scopus 로고
    • Low molecular weight heparin prevents the pulmonary hemodynamic and pathomorphologic effects of endotoxin in a porcine acute lung injury model
    • Darien BJ, Fareed J, Centgraf KS, et al. Low molecular weight heparin prevents the pulmonary hemodynamic and pathomorphologic effects of endotoxin in a porcine acute lung injury model. Shock 1998; 9:274-281
    • (1998) Shock , vol.9 , pp. 274-281
    • Darien, B.J.1    Fareed, J.2    Centgraf, K.S.3
  • 14
    • 0029780448 scopus 로고    scopus 로고
    • Are the available low-molecular-weight heparin preparations the same?
    • Fareed J, Jeske W, Hoppensteadt D, et al. Are the available low-molecular-weight heparin preparations the same? Semin Thromb Haemost 1996; 22(suppl 1):77-91
    • (1996) Semin Thromb Haemost , vol.22 , Issue.SUPPL. 1 , pp. 77-91
    • Fareed, J.1    Jeske, W.2    Hoppensteadt, D.3
  • 15
    • 0031051446 scopus 로고    scopus 로고
    • Production method affects the pharmacokinetic and ex vivo biological properties of low molecular weight heparins
    • Brieger D, Dawes J. Production method affects the pharmacokinetic and ex vivo biological properties of low molecular weight heparins. Thromb Haemost 1997; 77:317-322
    • (1997) Thromb Haemost , vol.77 , pp. 317-322
    • Brieger, D.1    Dawes, J.2
  • 16
    • 0016045133 scopus 로고
    • Growth of the heart and lungs in hypoxic rodents: A model of human hypoxic disease
    • Hunter C, Barer GR, Shaw JW, et al. Growth of the heart and lungs in hypoxic rodents: a model of human hypoxic disease. Clin Sci Mol Med 1974; 46:375-391
    • (1974) Clin Sci Mol Med , vol.46 , pp. 375-391
    • Hunter, C.1    Barer, G.R.2    Shaw, J.W.3
  • 18
    • 0018340698 scopus 로고
    • The pulmonary circulation: Remodeling in growth and disease: the 1978
    • Reid LM. The pulmonary circulation: remodeling in growth and disease: the 1978 J. Burns Amberson lecture. Am Rev Respir Dis 1979; 119:531-546
    • (1979) J. Burns Amberson lecture. Am Rev Respir Dis , vol.119 , pp. 531-546
    • Reid, L.M.1
  • 19
    • 0017836440 scopus 로고
    • The effect of continued hypoxia on rat pulmonary arterial circulation: An ultrastructural study
    • Meyrick B, Reid L. The effect of continued hypoxia on rat pulmonary arterial circulation: an ultrastructural study. Lab Invest 1978; 38:188-200
    • (1978) Lab Invest , vol.38 , pp. 188-200
    • Meyrick, B.1    Reid, L.2
  • 20
    • 0029865044 scopus 로고    scopus 로고
    • Differential effect of three commercial heparins on Na+/H+ exchange and growth of PASMC
    • Dahlberg CG, Thompson BT, Joseph PM, et al. Differential effect of three commercial heparins on Na+/H+ exchange and growth of PASMC. Am J Physiol 1996; 270:L260-L265
    • (1996) Am J Physiol , vol.270
    • Dahlberg, C.G.1    Thompson, B.T.2    Joseph, P.M.3
  • 21
    • 0019829625 scopus 로고
    • Cultured endothelial cells produce a heparin-like inhibitor of smooth muscle cell growth
    • Castellot JJ Jr, Addonizio ML, Rosenberg R, et al. Cultured endothelial cells produce a heparin-like inhibitor of smooth muscle cell growth. J Cell Biol 1981; 90:372-379
    • (1981) J Cell Biol , vol.90 , pp. 372-379
    • Castellot Jr, J.J.1    Addonizio, M.L.2    Rosenberg, R.3
  • 22
    • 0017576983 scopus 로고
    • Suppression by heparin of smooth muscle cell proliferation in injured arteries
    • Clowes AW, Karnowsky MJ. Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature 1977; 265:625-626
    • (1977) Nature , vol.265 , pp. 625-626
    • Clowes, A.W.1    Karnowsky, M.J.2
  • 23
    • 0018950165 scopus 로고
    • Inhibition of rat arterial smooth muscle cell proliferation by heparin: II. In vitro studies
    • Hoover RL, Rosenberg R, Haering W, et al. Inhibition of rat arterial smooth muscle cell proliferation by heparin: II. In vitro studies. Circ Res 1980; 47:578-583
    • (1980) Circ Res , vol.47 , pp. 578-583
    • Hoover, R.L.1    Rosenberg, R.2    Haering, W.3
  • 24
    • 0025081635 scopus 로고
    • Endothelial heparan sulfate proteoglycan: I. Inhibitory effects on smooth muscle cell proliferation
    • Benitz WE, Kelley RT, Anderson CM, et al. Endothelial heparan sulfate proteoglycan: I. Inhibitory effects on smooth muscle cell proliferation. Am J Respir Cell Mol Biol 1990; 2:13-24
    • (1990) Am J Respir Cell Mol Biol , vol.2 , pp. 13-24
    • Benitz, W.E.1    Kelley, R.T.2    Anderson, C.M.3
  • 25
    • 0021889240 scopus 로고
    • Binding and internalization of heparin by vascular smooth muscle cells
    • Castellot JJ Jr, Wong K, Herman B, et al. Binding and internalization of heparin by vascular smooth muscle cells. J Cell Physiol 1985; 124:13-20
    • (1985) J Cell Physiol , vol.124 , pp. 13-20
    • Castellot Jr, J.J.1    Wong, K.2    Herman, B.3
  • 26
    • 0020404071 scopus 로고
    • Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin: Possible role of a platelet endoglycosidase
    • Castellot JJ Jr, Favreau LV, Karnovsky MJ, et al. Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin: possible role of a platelet endoglycosidase. J Biol Chem 1982; 257:11256-11260
    • (1982) J Biol Chem , vol.257 , pp. 11256-11260
    • Castellot Jr, J.J.1    Favreau, L.V.2    Karnovsky, M.J.3
  • 27
    • 0020606230 scopus 로고
    • Impairment of hypoxic pulmonary artery remodeling by heparin in mice
    • Hales CA, Kradin RL, Brandstetter RD, et al. Impairment of hypoxic pulmonary artery remodeling by heparin in mice. Am Rev Respir Dis 1983; 128:747-751
    • (1983) Am Rev Respir Dis , vol.128 , pp. 747-751
    • Hales, C.A.1    Kradin, R.L.2    Brandstetter, R.D.3
  • 29
    • 0037470456 scopus 로고    scopus 로고
    • Heparin inhibits SMC growth in the presence of human and fetal bovine serum
    • Cindhuchao N, Quinn DA, Garg HG, et al. Heparin inhibits SMC growth in the presence of human and fetal bovine serum. Biochem Biophys Res Commun 2003; 302:84-88
    • (2003) Biochem Biophys Res Commun , vol.302 , pp. 84-88
    • Cindhuchao, N.1    Quinn, D.A.2    Garg, H.G.3
  • 30
    • 0035912864 scopus 로고    scopus 로고
    • Guide to anticoagulant therapy: Heparin; a statement for healthcare professionals from the American Heart Association
    • Hirsh J, Anand SS, Halperin JL, et al. Guide to anticoagulant therapy: heparin; a statement for healthcare professionals from the American Heart Association. Circulation 2001; 103:2994-3018
    • (2001) Circulation , vol.103 , pp. 2994-3018
    • Hirsh, J.1    Anand, S.S.2    Halperin, J.L.3
  • 31
    • 17444415310 scopus 로고    scopus 로고
    • Safety profile of different low-molecular weight heparins used at therapeutic dose
    • Gouin-Thibanlt I, Pautas E, Siguret V. Safety profile of different low-molecular weight heparins used at therapeutic dose. Drug Saf 2005; 28:333-349
    • (2005) Drug Saf , vol.28 , pp. 333-349
    • Gouin-Thibanlt, I.1    Pautas, E.2    Siguret, V.3
  • 32
    • 0026593425 scopus 로고
    • Low molecular weight heparin
    • Hirsh J, Levine MN. Low molecular weight heparin. Blood 1992; 79:1-17
    • (1992) Blood , vol.79 , pp. 1-17
    • Hirsh, J.1    Levine, M.N.2
  • 33
    • 0030858230 scopus 로고    scopus 로고
    • Low-molecular-weight heparins
    • Weitz JI. Low-molecular-weight heparins. N Engl J Med 1997; 337:688-698
    • (1997) N Engl J Med , vol.337 , pp. 688-698
    • Weitz, J.I.1
  • 34
    • 0026316713 scopus 로고
    • Polycythemia and vascular remodeling in chronic hypoxic pulmonary hypertension in guinea pigs
    • Janssens SP, Thompson BT, Spence CR, et al. Polycythemia and vascular remodeling in chronic hypoxic pulmonary hypertension in guinea pigs. J Appl Physiol 1991; 71:2218-2223
    • (1991) J Appl Physiol , vol.71 , pp. 2218-2223
    • Janssens, S.P.1    Thompson, B.T.2    Spence, C.R.3
  • 35
    • 0242469234 scopus 로고    scopus 로고
    • Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight
    • Khorana AA, Sahni A, Altland OD, et al. Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight. Arterioscler Thromb Vasc Biol 2003; 23:2110-2115
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 2110-2115
    • Khorana, A.A.1    Sahni, A.2    Altland, O.D.3
  • 36
    • 0028217757 scopus 로고
    • Modulation of human fibroblast activity by selected angiogenesis inhibitors
    • Wong J, Wang N, Miller JW, et al. Modulation of human fibroblast activity by selected angiogenesis inhibitors. Exp Eye Res 1994; 58:439-451
    • (1994) Exp Eye Res , vol.58 , pp. 439-451
    • Wong, J.1    Wang, N.2    Miller, J.W.3
  • 37
    • 0031560415 scopus 로고    scopus 로고
    • Influence of molecular weight, protein core and charge of native heparin fractions on pulmonary artery smooth muscle cell proliferation
    • Joseph PA, Garg HG, Thompson BT, et al. Influence of molecular weight, protein core and charge of native heparin fractions on pulmonary artery smooth muscle cell proliferation. Biochem Biophys Res Commun 1997; 241:18-23
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 18-23
    • Joseph, P.A.1    Garg, H.G.2    Thompson, B.T.3
  • 38
    • 0024581580 scopus 로고
    • Structural determinants of heparin's growth inhibitory activity: Interdependence of oligosaccharide size and charge
    • Wright TC Jr, Castellot JJ Jr, Petitou M, et al. Structural determinants of heparin's growth inhibitory activity: interdependence of oligosaccharide size and charge. J Biol Chem 1989; 264:1534-1542
    • (1989) J Biol Chem , vol.264 , pp. 1534-1542
    • Wright Jr, T.C.1    Castellot Jr, J.J.2    Petitou, M.3
  • 39
    • 0032702533 scopus 로고    scopus 로고
    • Structural features and bleeding activity of commercial low molecular weight heparins: Neutralization by ATP and protamine
    • Dietrich CP, Shinjo SK, Moraes FA, et al. Structural features and bleeding activity of commercial low molecular weight heparins: neutralization by ATP and protamine. Semin Thromb Haemost 1999; 25(suppl 3):43-50
    • (1999) Semin Thromb Haemost , vol.25 , Issue.SUPPL. 3 , pp. 43-50
    • Dietrich, C.P.1    Shinjo, S.K.2    Moraes, F.A.3
  • 40
    • 0025428735 scopus 로고
    • Endothelial cell proteoglycans: Possible mediators of vascular responses to injury
    • Benitz WE, Bernfield M. Endothelial cell proteoglycans: possible mediators of vascular responses to injury. Am J Respir Cell Mol Biol 1990; 2:407-408
    • (1990) Am J Respir Cell Mol Biol , vol.2 , pp. 407-408
    • Benitz, W.E.1    Bernfield, M.2
  • 41
    • 0027223173 scopus 로고
    • Effect of the desulfation of heparin on its anticoagulant and anti-proliferative activity
    • Tiozzo R, Cingi MR, Reggiani D, et al. Effect of the desulfation of heparin on its anticoagulant and anti-proliferative activity. Thromb Res 1993; 70:99-106
    • (1993) Thromb Res , vol.70 , pp. 99-106
    • Tiozzo, R.1    Cingi, M.R.2    Reggiani, D.3
  • 42
    • 4844226355 scopus 로고    scopus 로고
    • Antiproliferative effects of low molecular weight heparin
    • Fletcher JP, Ao PY, Hawthorne WJ. Antiproliferative effects of low molecular weight heparin. ANZ J Surg 2004; 74:793-796
    • (2004) ANZ J Surg , vol.74 , pp. 793-796
    • Fletcher, J.P.1    Ao, P.Y.2    Hawthorne, W.J.3
  • 43
    • 0031758671 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight heparin: Mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety
    • Hirsh J, Warkentin TE, Raschke R, et al. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest 1998; 114:489S-510S
    • (1998) Chest , vol.114
    • Hirsh, J.1    Warkentin, T.E.2    Raschke, R.3
  • 44
    • 24044515025 scopus 로고    scopus 로고
    • Low molecular weight heparins: Are they different?
    • Fareed J, Hoppensteadt D, Jeske W, et al. Low molecular weight heparins: are they different? Can J Cardiol 1998; 14(suppl E):28E-34E
    • (1998) Can J Cardiol , vol.14 , Issue.SUPPL. E
    • Fareed, J.1    Hoppensteadt, D.2    Jeske, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.