Neuroprotection by 7-nitroindazole against iron-induced hippocampal neurotoxicity

Cellular and Molecular Neurobiology

Volumn 27, Issue 7, 2007, Pages 933-941

  Bostanci, M Ömer ^a   Bağirici, Faruk ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

7 Nitroindazole; Cell death; Hippocampus; Iron; Stereology

Indexed keywords

7 NITROINDAZOLE; ARACHIS OIL; FERRIC CHLORIDE; IRON; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANESTHESIA; ARTICLE; BRAIN VENTRICLE; CELL COUNT; CELL LOSS; CONTROLLED STUDY; HIPPOCAMPUS; HISTOLOGY; MALE; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOMETRY;

ANIMALIA; ARACHIS HYPOGAEA; RATTUS;

EID: 37549000559     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-007-9223-4     Document Type: Article

References (49)

1. Aisen P, Wessling-Resnick M, Leibold EA (1999) Iron metabolism. Curr Opin Chem Biol 3:200-206
2. Aust SD, Morehouse LA, Thomas CE (1985) Role of metals in oxygen radicals reactions. J Free Rad Biol Med 1:3-25
3. Babbedge RC, Bland-Wart PA, Hart SL, Moore PK (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br J Pharmacol 110:225-228
4. Beckman JS, Beckman TW, Chen J, Marshall PM, Freeman BA (1990) Apparent hydroxyl radicals production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624
5. Bostanci MO, Bagirici F, Korkmaz A (2003) The neurotoxic effect of iron on pyramidal cell number in rat hippocampus: a stereological study. Neurosci Res Commun 32:151-159
6. Bostanci MO, Bagirici F, Canan S (2006) A calcium channel blocker flunarizine attenuates the neurotoxic effects of iron. Cell Biol Toxicol 22:119-125
7. Braughler JM, Duncan LA, Chase RL (1986) The involvement of iron in lipid peroxidation. J Biol Chem 261:10282-10289
8. Danielisova V, Nemethova M, Burda J (2004) The protective effect of aminoguanidine on cerebral ischemic damage in the rat brain. Physiol Res 53:533-540
9. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368-6371
10. Dawson TM, Dawson VL, Snyder SH (1992) A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol 32:297-311
11. Deibel MA, Ehmann WD, Markesbery WR (1996) Copper, iron and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress. J Neurol Sci 143:137-142
12. Endoh M, Maiese K, Wagner JA (1994) Expression of the neural form of nitric oxide synthase by CA1 hippocampal neurons and other central nervous system neurons. Neuroscience 63:679-689
13. Garthwaite J, Boulton CL (1995) Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57:683-706
14. Gokce FM, Bagirici F, Kaplan S, Demir S, Ayyildiz M, Marangoz C (2003) A NOS inhibitor aminoguanidine reduces zinc-induced neuron loss in rat hippocampus. Neurosci Res Commun 33:53-62
15. Guevara BH, Cespedes GC, Cubeddu LX (2002) Treatment with 7-nitroindazole enhances kainic acid induced cholinergic neurotoxicity in the rat striatum: a neuroprotective role for neuronal nitric oxide. Cell Mol Neurobiol 22:827-834
16. Gundersen HJ (1986) Stereology of arbitrary particles. A review of unbiased number and size estimator and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143:3-45
17. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379-94
18. Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS (1992) Peroxynitrite mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 298:431-437
19. Jang MH, Shin MC, Chang HK, Lee TH, Lee HH, Shin MS, Kim CJ, Kang JO, Hong SP, Cho S (2004) 7-nitroindazole reduces ischemia-induced increment of apoptosis and cell proliferation in the dentate gyrus of rats. Neurosci Res Commun 35:164-172
20. Jones PA, Smith RA, Stone TW (1998) Nitric oxide synthase inhibitors L-NAME and 7-nitroindazole protect rat hippocampus against kainate-induced excitotoxicity. Neurosci Lett 249:75-78
21. Lafon-Cazal M, Culcasi M, Gaven F, Pietri S, Bockaert J (1993) Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells. Neuropharmacology 32:1259-1266
22. Lin AMY (1999) Recovery by NO of the iron-attenuated dopamine dynamics in nigrostriatal system of rat brain. Neurosci Res 34:133-139
23. Meldrum B, Garthwaite J (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trend Pharmacol Sci 11:379-387
24. Meyerhoff JL, Lee JK, Rittase BW, Tsang AY, Yourick DL (2004) Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat. Brain Res 1016:139-144
25. Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012
26. Montecot C, Borredon J, Seylaz J, Pinard E (1997) Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate. J Cereb Blood Flow Metab 17:94-99
27. Montecot C, Rondi Reig L, Springhetti V, Seylaz J, Pinard E (1998) Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperemia and hippocampal lesions resulting from kainate-induced seizures. Neuroscience 84:791-800
28. Moore PK, Babbedge RC, Wallace P, Gaffen ZA, Hart SL (1993) 7-Nitroindazol, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol 108:296-297
29. Moos T (2002) Brain iron homeostasis. Dan Med Bull 49:279-301
30. Muramatsu Y, Kurosaki R, Mikami T, Michimata M, Matsubara M, Imai Y, Kato H, Itoyama Y, Araki T (2002) Therapeutic effect of neuronal nitric oxide synthase inhibitor (7-nitroindazole) against MPTP neurotoxicity in mice. Metab Brain Dis 17:169-182
31. Pantopoulos K, Weiss G, Hentze M (1994) Nitric oxide and the post-transcriptional control of cellular iron traffic. Trends Cell Biol 4:82-86
32. Paxinos G, Watson C (1998) The rat brain in the stereotaxic coordinates, 4th edn. Academic Press, London
33. Qian ZM, Shen X (2001) Brain iron transport and neurodegeneration. Trends Mol Med 7:103-108
34. Qian ZM, Wang Q (1998) Expression of iron transport proteins and excessive iron accumulation of iron in the brain in neurodegenerative disorders. Brain Res Rev 27:257-267
35. Qian ZM, Wang Q, Pu Y (1997) Brain iron and neurological disorders. Chin Med J 110:455-458
36. Rauhala P, Sziraki I, Chiueh CC (1996) Peroxidation of brain lipids in vitro: nitric oxide versus hydroxyl radicals. Free Rad Biol Med 21:391-394
37. Reif DW, Simmons RD (1990) Nitric oxide mediates iron release from ferritin. Arch Biochem Biophy 283:537-541
38. Samudralwer DL, Diprete CC, Ni B-F, Ehmann WD, Markesbery WR (1995) Elemental imbalances in the olfactory pathway in Alzheimer's disease. J Neurol Sci 130:139-145
39. Skaper SD, Ancona B, Facci L, Franceschini D, Giusti P (1998) Melatonin prevents the delayed death of hippocampal neurons induced by enhanced excitatory neurotransmission and the nitridergic pathway. FASEB J 12:725-731
40. Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 134:127-136
41. Swaiman KF (1991) Hallervorden-Spatz and brain iron metabolism. Arch Neurol 48:1285-1293
42. Tipton KF, Singer TP (1993) Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem 61:1191-1206
43. Van der Vliet A, O'Neill CA, Halliwell B, Cross CE, Kaur H (1994) Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitrite. FEBS Lett 339:89-92
44. Verrecchia C, Boulu RG, Plotkine M (1995) Neuroprotective and deleterious effects of nitric oxide on focal cerebral ischemia-induced neuron death. Adv Neuroimmunol 5:359-378
45. Wendland B, Schweizer FE, Ryan TA, Nakane M, Murad F, Scheller RH Tsien RW (1994) Existence of nitric oxide synthase in rat hippocampal pyramidal cells. Proc Natl Acad Sci 91:2151-2155
46. West MJ, Slomianka L, Gundersen HJG (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Record 231:482-497
47. Willmore LJ, Triggs WJ (1991) Iron-induced lipid peroxidation and brain injury responses. Int J Dev Neurosci 9:175-180
48. Willmore LJ, Hiramatsu M, Kochi H, Mori A (1983) Formation of superoxide radicals after FeCl3 injection into rat isocortex. Brain Res 277:393-396
49. Yang SN, Hsieh WY, Liu DD, Tsai LM, Tung CS, Wu JN (1998) The involvement of nitric oxide in synergistic neuronal damage induced by β-amyloid peptide and glutamate in primary cortical neurons. Chin J Physiol 41:175-179