Higher gastric mucin secretion and lower gastric acid output in first-degree relatives of gastric cancer patients

Journal of Clinical Gastroenterology

Volumn 42, Issue 1, 2008, Pages 36-41

  Vilkin, Alexander ^a   Levi, Zohar ^a   Morgenstern, Sara ^a   Shmuely, Haim ^a   Gal, Eyal ^a   Hadad, Bracha ^a   Hardi, Britta ^b   Niv, Yaron ^a  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Gastric acid; Gastric cancer; Mucin; Relatives of gastric cancer patients; Stomach

Indexed keywords

STOMACH MUCIN;

ADULT; AGED; ARTICLE; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPEPSIA; ESOPHAGOGASTRODUODENOSCOPY; FAMILY HISTORY; FEMALE; GASTRITIS; HELICOBACTER INFECTION; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN SECRETION; RELATIVE; STOMACH ACID SECRETION; STOMACH BIOPSY; STOMACH CANCER; STOMACH JUICE;

ACHLORHYDRIA; ADOLESCENT; ADULT; AGED; COHORT STUDIES; DISEASE SUSCEPTIBILITY; FAMILY HEALTH; GASTRIC MUCIN; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INFLAMMATION; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; RISK FACTORS; STOMACH NEOPLASMS;

EID: 37548998958     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3181574d39     Document Type: Article

References (39)

1. Neutra MR, Forstrer JF. Gastrointestinal mucus: synthesis, secretion and function. In: Johnson DF, ed. Physiology of the Gastrointestinal Tract. 2nd ed. New York: Raven; 1987:975-1009.
2. Gendler SJ, Spicer AP. Epithelial mucin genes. Ann Rev Physiol. 1995;57:607-634.
3. Abe M, Kufe D. Characterization of cis-acting elements regulating transcription of human DF3 breast carcinoma associated antigen (MUC1) gene. Proc Natl Acad Sci U S A. 1993;90:282-286.
4. Gum JR, Byrd JC, Hicks JW, et al. Molecular cloning of human intestinal mucin cDNAs: sequence analysis and evidence for genetic polymorphism. J Biol Chem. 1989;264:6480-6487.
5. Gum JR, Hicks JW, Swallow DM, et al. Molecular cloning of cDNA derived from a novel human intestinal mucin gene. Biochem Biophys Res Commun. 1990;171:407-415.
6. Porchet N, Van Cong N, Dufosse J, et al. Molecular cloning and chromosomal localization of novel human tracheobronchial mucin cDNA containing tandemly repeated sequence of 48 base pairs. Biochem Biophys Res Commun. 1991;175:414-422.
7. Meerzaman D, Charles P, Daskal E, et al. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). J Biol Chem. 1994;269:12932-12939.
8. Toribara NW, Roberton AM, Ho SB, et al. Human gastric mucin: identification of a sequence species by expression cloning. J Biol Chem. 1993;268:5879-5885.
9. Bobek LA, Tasai H, Biesbrock AR, et al. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). J Biol Chem. 1993;268:20563-20569.
10. D'Cruz OJ, Haas GG, Dunn TS, et al. Antigenic cross reactivity of human tracheal mucin with human sperm and trophoblasts correlates with the expression of mucin 8 gene messenger ribonucleic acid in reproductive tract tissues. Fertil Steril. 1996;66:316-326.
11. Lapensee L, Paquette Y, Bleau G. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). Fertil Steril. 1997;68:702-708.
12. Williams SJ, Wreschner DH, Tran M, et al. MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem. 2001;276:18327-18336.
13. Yin BW, Lloyd KO. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J Biol Chem. 2001;276:27371-27375.
14. Gum JR, Crawley SC, Hicks JW, et al. MUC17, a novel membrane-tethered mucin. Biochem Biophys Res Commun. 2002;291:466-475.
15. Carrato C, Balague C, de Bolos C, et al. Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology. 1994;107:160-172.
16. Ho SB, Roberton AM, Shekels LL, et al. Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression. Gastroenterology. 1995;109:735-747.
17. Ho SB, Niehans GA, Lyftogt C, et al. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res. 1993;53:641-651.
18. Ho SB, Shekels LL, Toribara NW, et al. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 1995;55:2681-2690.
19. Ota H, Nakayama J, Momose M, et al. Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins. Virchows Arch. 1998;433:419-426.
20. Byrd JC, Yunker CK, Xu Q, et al. Inhibition of gastric mucin synthesis by Helicobacter pylori. Gastroenterology. 2000;118:1072-1079.
21. Beil W, Enss ML, Muller S, et al. Role of vacA and cagA in Helicobacter pylori inhibition of mucin synthesis in gastric mucous cells. J Clin Microbiol. 2000;38:2215-2218.
22. Morgenstern S, Koren R, Moss SF, et al. Does Helicobacter pylori affect gastric mucin expression? Relationship between gastral antral mucin expression and Helicobacter pylori colonization. Eur J Gastroenterol Hepatol. 2001;13:19-23.
23. Byrd JC, Yan P, Sternberg LR, et al. Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients. Gastroenterology. 1997;113:455-464.
24. El-Omar EM, Penman ID, Ardill JE, et al. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology. 1995;109:681-691.
25. Hansson L-E, Nyrén O, Hsing AW, et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335:242-249.
26. El-Omar EM, Oien K, El-Nujumi A, et al. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology. 1997;113:15-24.
27. Correa P. A human model of gastric carcinogenesis. Cancer Res. 1988;48:3554-3560.
28. La Vecchia C, Negri E, Franceschi S, et al. Family history and the risk of stomach and colorectal cancer. Cancer. 1992;70:50-55.
29. Brenner H, Arndt V, Sturmer T, et al. Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma. Cancer. 2000;88:274-279.
30. El-Omar EM, Oien K, Murray LS, et al. Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori. Gastroenterology. 2000;118:22-30.
31. Sepulveda A, Peterson LE, Shelton J, et al. Histological patterns of gastritis in H. pylori-infected individuals with a family history of gastric cancer. Am J Gastroenterol. 2002;97:1365-1370.
32. Niv Y, Hardy B, Koren R, et al. Association between gastric acid and mucin secretion in dyspeptic patients. Digestion. 2002;65:141-148.
33. Wolfe MM, Nompleggi DJ. Cytokine inhibition of gastric acid secretion - a little goes a long way. Gastroenterology. 1992;102:2177-2178.
34. Gray T, Nettesheim P, Loftin C, et al. Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. Mol Pharmacol. 2004;66:337-346.
35. Gray T, Coakley R, Hirsh A, et al. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 2004;286:L320-L330.
36. Kim YD, Kwon EJ, Park DW, et al. Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol. 2002;62:1112-1118.
37. Clyne M, Dillon P, Daly S, et al. Helicobacter pylori interacts with the human single-domain trefoil protein TFF1. Proc Natl Acad Sci U S A. 2004;101:7409-7414.
38. Van de Bovenkamp JH, Mahdavi J, Korteland-Van Male AM, et al. H. pylori colocalizes with MUC5AC in the human stomach. Gut. 2000;46:601-607.
39. Linden S, Nordman H, Hedenbro J, et al. Strain- and blood group-dependent binding of Helicobacter pylori to human gastric MUC5AC glycoforms. Gastroenterology. 2002;123:1923-1930.