Preparation of rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation

International Journal of Pharmaceutics

Volumn 349, Issue 1-2, 2008, Pages 241-248

  Yuan, Xu Bo ^a   Yuan, Yan Bo ^b   Jiang, Wei ^c   Liu, Jie ^a   Tian, En Jiang ^c   Shun, Hui Ming ^c   Huang, Ding Hai ^a   Yuan, Xiao Yan ^a   Li, Hong ^d   Sheng, Jing ^a  

^a TIANJIN UNIVERSITY   (China)

^b CHANGZHI MEDICAL COLLEGE   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

^d NANKAI UNIVERSITY   (China)

Author keywords

Chitosan; Corneal transplantation; Immunosuppression; Nanoparticles; Polylactic acid

Indexed keywords

CHITOSAN; RAPAMYCIN;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORNEA TRANSPLANTATION; DRUG COATING; DRUG FORMULATION; GAMMA SCINTIGRAPHY; GRAFT SURVIVAL; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SLIT LAMP; SURVIVAL TIME; SUSTAINED DRUG RELEASE; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; ZETA POTENTIAL;

ADMINISTRATION, TOPICAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CHOLESTEROL; CORNEAL TRANSPLANTATION; DRUG CARRIERS; ELECTROCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; ISOTOPE LABELING; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; OPHTHALMIC SOLUTIONS; POLYMERS; RABBITS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; SIROLIMUS; SOLUBILITY; TECHNETIUM TC 99M PENTETATE;

EID: 37449030662     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.07.045     Document Type: Article

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