Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis

Modern Rheumatology

Volumn 17, Issue 6, 2007, Pages 511-513

  Abe, Koki ^a,b   Mitsuka, Takeshi ^b   Kanamori, Shigeo ^a   Yamashita, Keishi ^b   Yamaoka, Akiyoshi ^b  

^a Chiba Tokushukai Hospital   (Japan)

^b Social Insurance Funabashi Central Hospital   (Japan)

Author keywords

Adverse effect; Gynecomastia; Methotrexate (MTX); Rheumatoid arthritis (RA)

Indexed keywords

BUCILLAMINE; LANSOPRAZOLE; MELOXICAM; METHOTREXATE; PREDNISOLONE; REBAMIPIDE; SALAZOSULFAPYRIDINE; TACROLIMUS;

AGED; ARTICLE; BREAST TENDERNESS; CASE REPORT; DISEASE COURSE; DRUG DOSE INCREASE; DRUG HYPERSENSITIVITY; DRUG SUBSTITUTION; DRUG TOLERANCE; DRUG WITHDRAWAL; FOLLOW UP; GYNECOMASTIA; HUMAN; LABORATORY TEST; LOW DRUG DOSE; MALE; MASTALGIA; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DOSE-RESPONSE RELATIONSHIP, DRUG; GYNECOMASTIA; HUMANS; MALE; METHOTREXATE; REMISSION INDUCTION; TACROLIMUS; WITHHOLDING TREATMENT;

EID: 37449012325     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-007-0619-2     Document Type: Article

References (11)

1. DW Del Paine JC Leek C Jakle DL Robbins 1983 Gynecomastia-associated with low dose methotrexate therapy (letter) Arthritis Rheum 26 691-2 6847735 10.1002/art.1780260523 1:STN:280:BiyB3cvis1M%3D
2. E Thomas JL Leroux F Blotman 1994 Gynecomastia in patients with rheumatoid arthritis treated with methotrexate (letter) J Rheumatol 21 1777-8 7799373 1:STN:280:ByqD1Mjjt1Y%3D
3. DR Finger GL Klippe 1995 Gynecomastia following low dose methotrexate therapy for rheumatoid arthritis (letter) J Rheumatol 22 796-7 7791195 1:STN:280:ByqA3M7ivFU%3D
4. MA Aguirre A Velez M Romero E Collantes 2002 Gynecomastia and Sexual Impotence Associated with Methotrexate Treatment J Rheumatol 29 1793-4 12180746
5. D Pandhi R Gupta A Singal 2005 Gynaecomastia with oligospermia: An unusual complication of low-dose methotrexate for pustular psoriasis (letter) Clin Exp Dermatol 31 138-40 10.1111/j.1365-2230.2005.01925.x
6. GD Baunstein N Engl J Med 1993 Gynecomastia N Engl J Med 7 328 490-5 10.1056/NEJM199302183280708
7. T Satoh S Itoh T Seki S Itoh N Nomura I Yoshizawa 2002 On the inhibitory action of 29 drugs having side effect gynecomastia on estrogen production J Steroid Biomol Biol 82 209-16 10.1016/S0960-0760(02)00154-1 1:CAS:528:DC%2BD38XptlCkur8%3D
8. AR Glass J Bereberg 1979 Gynaecomastia after chemotherapy for lymphoma Arch Intern Med 139 1048-9 582502 10.1001/archinte.139.9.1048 1:STN:280:CSaB2Mvos1A%3D
9. M Koehler R Waldherr R Ludwig U Heinrich WE Brandeis 1986 Effects of methotrexate on rabbit testes. Part 1: Morphological changes Pediatr Hematol Oncol 3 325-34 3153246 10.3109/08880018609031234 1:CAS:528:DyaL2sXitVOhurY%3D
10. M Koehler U Heinrich R Ludwig R Waldherr WE Brandeis 1986 Effects of methotrexate on rabbit testes. Part 2: Hormonal changes Pediatr Hematol Oncol 3 335-41 3155255 10.3109/08880018609031235 1:CAS:528:DyaL2sXitVOhurc%3D
11. RC Shamberger SA Rosenberg CA Siepp RJ Sherins 1981 Effects of high-dose methotrexate and vincristine on ovarian and testicular functions in patients undergoing postoperative adjuvant treatment of osteosarcoma Cancer Treat Rep 65 9-10 739-46 6791818 1:CAS:528:DyaL3MXltVyrtro%3D