Hormonal Regulation and Calcium Metabolism in the Rabbit

Veterinary Clinics of North America - Exotic Animal Practice

Volumn 11, Issue 1, 2008, Pages 139-152

  Eckermann Ross, Christine ^a,b  

^a Avian and Exotic Animal Care   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CALCIUM; PARATHYROID HORMONE; VITAMIN D;

ANIMAL; ANIMAL DISEASE; BONE; FEMALE; HOMEOSTASIS; KIDNEY; MALE; METABOLISM; PARATHYROID DISEASE; PHYSIOLOGY; RABBIT; REVIEW;

ANIMALS; BONE AND BONES; CALCITONIN; CALCIUM; FEMALE; HOMEOSTASIS; KIDNEY; MALE; PARATHYROID DISEASES; PARATHYROID HORMONE; RABBITS; VITAMIN D;

ANIMALIA; MAMMALIA; ORYCTOLAGUS CUNICULUS; VERTEBRATA;

EID: 37449007755     PISSN: 10949194     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvex.2007.09.002     Document Type: Review

References (92)

1. Ruckebusch Y., Phaneuf L.P., and Dunlop R. Physiology of small and large animals (1991), B.C. Decker, Inc, Philadelphia p. 521-6
2. Rosol T.J., and Capen C.C. Calcium-regulating hormones and diseases of abnormal mineral (calcium, phosphorous, magnesium) metabolism. In: Kaneko J.J., Harvey J.W., and Bruss M.L. (Eds). Clinical biochemistry of domestic animals. 5th edition (1997), Academic Press, San Diego (CA) 619-702
3. Warren H.B., Lausen N.C., Segre G.V., et al. Regulation of calciotropic hormones in vivo in the New Zealand white rabbit. Endocrinology 125 5 (1989) 2683-2690
4. Harcourt-Brown M.F. Calcium metabolism in rabbits. Exotic DVM Magazine 6 2 (2005) 11-14
5. Reece W.O. Functional anatomy and physiology of domestic animals. 3rd edition (2005), Lippincott, Williams & Wilkins, Philadelphia p. 293, 465
6. Redrobe S. Calcium metabolism in rabbits. Seminars in avian and exotic pet medicine 2002;11(2):94-101.
7. Levine B.S., Walling M.W., and Coburn J.W. Intestinal absorption of calcium; its assessment, normal physiology, and alterations in various disease states. In: Bronner F., and Coburn J.W. (Eds). Disorders of mineral metabolism, vol. 2, calcium physiology (1982), Academic Press, New York 104-188
8. Kamphues J., Carstensen D., Schroeder D., et al. Effects of increasing calcium and vitamin D supply on calcium metabolism of rabbits. J Anim Physiol Anim Nutr 56 (1986) 191-208
9. Bourdeau J.E., Schwer-Dymerski D.A., Stern P.H., et al. Calcium and phosphorus metabolism in chronically vitamin D deficient laboratory rabbits. Miner Electrolyte Metab 12 (1986) 176-185
10. Cheeke P.R., and Amberg J.W. Comparative calcium excretion by rats and rabbits. J Anim Sci 37 2 (1973) 450-454
11. Shadle A.R. The attrition and extrusive growth of the four major incisor teeth of domestic rabbits. Journal of Mammology 17 (1936) 15-21
12. Shareghi G.R., and Stoner L.C. Calcium transport across segments of the rabbit distal nephron in vitro. Am J Physiol 235 4 (1978) F367-F375
13. Massry S.G. Renal handling of calcium. In: Bronner F., and Coburn J.W. (Eds). Disorders of mineral metabolism, vol. 2, calcium physiology (1982), Academic Press, New York 189-235
14. Kennedy A. The urinary excretion of calcium by normal rabbits. J Comp Pathol 75 (1965) 69-74
15. Whiting S.J., and Quamme G.A. Effects of dietary calcium on renal calcium, magnesium and phosphate excretion by the rabbit. Miner Electrolyte Metab 10 (1984) 217-221
16. Buss S.L., and Bourdeau J.E. Calcium balance in laboratory rabbits. Miner Electrolyte Metab 10 (1984) 127-132
17. Harcourt-Brown F. Textbook of rabbit medicine (2002), Butterworth Heineman, Oxford (UK) p. 19-51, 185-92, 339
18. Berndt T., Marchand T., Sell T., et al. The effects of parathyroid hormone (PTH) and calcitonin (CT) on electrolyte and cyclic AMP (cAMP) excretion in the rabbit. Fed Proc 37 3 (1978) 728
19. Habener J.F., Rosenblatt M., and Potts J.T. Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action and metabolism. Physiol Rev 64 3 (1984) 985-1053
20. Berndt T.J., and Knox F.G. Effects of parathyroid hormone and calcitonin on electrolyte excretion in the rabbit. Kidney Int 17 (1980) 473-478
21. Suki W.N., and Rouse D. Hormonal regulation of calcium transport in thick ascending limb renal tubules. Am J Physiol 241 (1981) (Renal fluid electrolyte Physiol 10):F171-4
22. Rocha A.S., Magaldi J.B., and Kokko J.P. Calcium and phosphate transport in isolated segments of rabbit Henle's loop. J Clin Invest 59 (1977) 975-983
23. Shimzu T., Yoshitomi K., Nakamura M., et al. Effects of PTH, calcitonin and cAMP on calcium transport in rabbit distal nephron segments. Am J Physiol 259 (1990) (Renal fluid electrolyte Physiol 28):F408-14
24. Imai M. Effects of parathyroid hormone and N6 O2-dibutyryl cyclic AMP on Ca2+ transport across the rabbit distal nephron segments perfused in vitro. Pflugers Arch 390 (1981) 145-151
25. Brunette M.G., Mailloux J., and Lajeunesse D. Calcium transport through the luminal membrane of the distal tubule. I. Interrelationship with sodium. Kidney Int 41 (1992) 281-288
26. Lajeunesse D., Bouhtiauy I., and Brunette M.G. Parathyroid hormone and hydrochlorothiazide increase calcium transport by the luminal membrane of rabbit distal nephron segments through different pathways. Endocrinology 134 1 (1994) 35-41
27. Morel F. Site of hormone action in the mammalian nephron. Am J Physiol 240 (1981) (Renal Fluid Electrolyte Physiol):F159-64
28. Chabardes D., Imbert M., Clique A., et al. PTH sensitive adenyl cyclase activity in different segments on the rabbit nephron. Pflugers Arch 354 (1975) 229-239
29. Talmage R.V., Cooper C.W., and Toverud S.U. The physiologic significance of calcitonin. Bone and Mineral Research 1 (1983) 74-143
30. Austin L.A., and Heath H. Calcitonin physiology and pathophysiology. N Engl J Med 304 5 (1981) 269-276
31. Kisloff B., and Moore E.W. Effects of intravenous calcitonin on water, electrolyte and calcium movement across in vivo rabbit jejunum and ileum. Gastroenterology 72 3 (1977) 462-468
32. Quamme G.A. Effect of calcitonin on calcium and magnesium transport in rat nephron. Am J Physiol 238 Endocrinol metab 1 (1980) E573-E575
33. Talmage R.V., and Grubb S.A. The influence of endogenous or exogenous calcitonin on daily urinary calcium excretion. Endocrinology 101 (1977) 1351-1357
34. Aldred J.P., Kleszynski R.R., and Bostian J.W. Effects of acute administration of porcine and salmon calcitonin on urine electrolyte excretion in rats. Proc Soc Exp Biol Med 134 (1970) 1175-1179
35. Cochran M., Peacock M., Sachs G., et al. Renal effects of calcitonin. Br Med J 1 (1970) 135-137
36. Zuo Q., Claveau D., Hilal G., et al. Effect of calcitonin on calcium transport by the luminal and basolateral membranes of the rabbit nephron. Kidney Int 51 (1997) 1991-1999
37. Aurbach G.D., and Heath D.A. Parathyroid hormone and calcitonin regulation of renal function. Kidney Int 6 (1974) 331-345
38. Chabardes D., Imbert-Teboul M., Montegut M., et al. Distribution of calcitonin-sensitive adenylate cyclase activity along the rabbit kidney tubule. Proc Natl Acad Sci U S A 73 10 (1976) 3608-3612
39. Luplescu A. Effect of synthetic salmon calcitonin on glucose, blood urea nitrogen and serum electrolytes in rabbits. J Pharmacol Exp Ther 188 2 (1974) 318-323
40. Salako L.A., Smith A.J., and Smith R.N. The effects of porcine calcitonin on renal function in the rabbit. J Endocrinol 50 (1971) 485-491
41. Bell N.H. Vitmain D-endocrine system. J Clin Invest 76 (1985) 1-6
42. Fraser D.R. Regulation of the metabolism of vitamin D. Physiol Rev 60 2 (1980) 551-613
43. 2D3 in regulating parathyroid gland function. Proc Soc Exp Biol Med 191 (1989) 233-237
44. Brommage R., Miller S.C., Langman C.B., et al. The effects of chronic vitamin D deficiency on the skeleton in the adult rabbit. Bone 9 (1988) 131-139
45. Nyomba B.L., Bouillon R., and DeMoor P. Influence of vitamin D status on insulin secretion and glucose tolerance in the rabbit. Endocrinology 115 (1984) 191-197
46. Kubota M., Ohno J., Shiina Y., et al. Vitamin D metabolism in pregnant rabbits: differences between the maternal and fetal response to administration of large amounts of vitamin D3. Endocrinology 110 (1982) 1950-1956
47. Dick I.M., Liu J., Glendenning P., et al. Estrogen and androgen regulation of plasma membrane calcium pump activity in immortalized distal tubule kidney cells. Mol Cell Endocrinol 212 (2003) 11-18
48. Burnette M.G., and Leclerc M. Effect of estrogen on calcium and sodium transport by the nephron luminal membranes. J Endocrinol 170 (2001) 441-450
49. Couchourel D., Leclerc M., Filep J., et al. Testosterone enhances calcium reabsorption by the kidney. Mol Cell Endocrinol 222 (2004) 71-81
50. Burnette M.G., and Leclerc M. Renal action of progesterone: effect on calcium reabsorption. Mol Cell Endocrinol 194 (2002) 183-190
51. Spanos E., Pike J.W., Haussler M.B., et al. Circulating 1-alpha-25-dihydroxy vitamin D in the chicken; enhancement by injection of prolactin during egg laying. Life Sci 19 (1976) 1751-1756
52. Mahajan K.K., Robinson C.J., and Horrobin D.F. Prolactin and hypercalcemia. Lancet 303 7868 (1974) 1237-1238
53. Lee Y.H., Huang W.C., Huang J.K., et al. Testosterone enhances whereas estrogen inhibits calcium oxalate stone formation in ethylene glycol treated rats. J Urol 156 (1996) 502-505
54. Lee Y., Huang W., chiang H., et al. Determinant role of testosterone in the pathogenesis of urolithiasis in rats. J Urol 147 (1992) 1134-1138
55. Aldrighi J.M., Lanz J.R., Mansur T.L.R., et al. Effect of sexual steroids on the calcium content of atherosclerotic plaque of oophorectomized rabbits. Braz J Med Biol Res 38 (2005) 705-711
56. Velasquez-Forero F., Garcia P., Triffitt J.T., et al. Prostaglandin E1 increases in vivo and in vitro calcitriol biosynthesis in rabbits. Prostaglandins Leukot Essent Fatty Acids 75 (2006) 107-115
57. Kimberg D.V., Baerg R.D., Geodron E., et al. Effect of cortisone treatment on the active transport of calcium by the small intestine. N Engl J Med 280 (1969) 1396-1405
58. Kimberg D.V. Effects of vitamin D and steroid hormones on the active transport of calcium by the intestine. N Engl J Med 280 25 (1969) 1396-1405
59. Rude R.K., and Singer F.R. Hormonal modifiers of mineral metabolism other than parathyroid hormone, vitamin D, and calcitonin. In: Bronner F., and Coburn J.W. (Eds). Disorders of mineral metabolism, vol. 2, calcium physiology (1982), Academic Press, New York 482-556
60. Collette C., Monnier L., Baldet T., et al. Evidence for alterations of vitamin D metabolism in methylprednisolone-treated rabbits. Horm Metab Res 15 (1983) 249-253
61. Eiler H., and Lyke A. Retention of calcium in intestinal wall of the rabbit by treatment with a glucocorticoid. Am J Physiol 245 Endocrinol Metab 8 (1983) E143-E147
62. Borowitz S.M., and Granrud G.S. Glucocorticoids inhibit intestinal phosphate absorption in developing rabbits. J Nutr 122 (1992) 1273-1279
63. Paloyan E., Paloyan D., and Harper P.V. Glucagon-induced hypocalcemia. Metabolism 16 1 (1967) 35-39
64. Pickleman J.R., Ernst K., Brown S., et al. Glucagon-induced hypocalcemia: effect of the thyroid gland. Surg Forum 20 (1969) 85-87
65. Flatt R.E., and Carpenter A.B. Identification of crystalline material in urine of rabbits. Am J Vet Res 32 4 (1971) 655-658
66. Whary M.T., and Peper R.L. Calcium carbonate urolithiasis in a rabbit. Lab Anim Sci 44 5 (1994) 534-536
67. Hoefer HL. Urolithiasis in rabbits and guinea pigs. In: Proceedings of the North American Veterinary Conference. Orlando (FL): 2006. p. 1735-6.
68. Capello V. Diagnosis and treatment of urolithiasis in pet rabbits. Exotic DVM Magazine 6 2 (2005) 15-22
69. Kamphues J. Calcium metabolism of rabbits as an etiological factor for urolithiasis. J Nutr 121 (1991) S95-S96
70. Itatani H., Yoshioka T., Namiki M., et al. Experimental model of calcium-containing renal stone formation in a rabbit. Investig Urol 17 3 (1979) 234-240
71. Ashcraft M.B., Southard K.A., and Tolley E.A. The effect of corticosteroid-induced osteoporosis on orthodontic tooth movement. Am J Orthod Dentofacial Orthop 102 (1992) 310-319
72. Harcourt-Brown F.M., and Baker S.J. Parathyroid hormone, haematological and biochemical parameters in relation to dental disease and husbandry in rabbits. J Small Anim Pract 42 (2001) 130-136
73. Harcourt-Brown F.M. A review of clinical conditions in pet rabbits associated with their teeth. Vet Rec 137 (1995) 341-346
74. Harcourt-Brown F.M. Calcium deficiency, diet and dental disease in pet rabbits. Vet Rec 139 (1996) 567-571
75. Bas S., Bas A., Estepa J.C., et al. Parathyroid gland function in the uremic rabbit. Domest Anim Endocrinol 26 (2004) 99-110
76. Bogin E., Malachi Z., Djaldeti M., et al. Effect of parathyroid hormone on the fragility and enzyme activities of red blood cells from young and mature rabbits. J Clin Chem Clin Biochem 25 (1987) 77-82
77. Garibaldi B.A., and Pecquet Goad M.E. Hypercalcemia with secondary nephrolithiasis in a rabbit. Lab Anim Sci 38 3 (1988) 331-333
78. Shell L.G., and Saunders G. Arteriosclerosis in a rabbit. J Am Vet Med Assoc 194 5 (1989) 679-680
79. Zimmerman J.E., Guddens W.T., DiGiaborno R.F., et al. Soft tissue mineralization in rabbits fed a diet containing excess vitamin D. Lab Anim Sci 40 2 (1990) 212-215
80. Quimby F., Foote R., Profit-Olstad M., et al. Hypercalcemia, hypercalcitoninism and arterial calcification in rabbits fed a diet containing excessive vitamin D and calcium. Lab Anim Sci 32 (1982) 415
81. Henneman P.H. Effects of high calcium intakes on renal function. Fed Proc 18 (1959) 1093-1096
82. Vernau K.M., Grahn B.H., Clarke-Scott H.A., et al. Thymoma in a geriatric rabbit with hypercalcemia and periodic exophthalmos. J Am Vet Med Assoc 206 6 (1995) 820-822
83. Bas S., Bas A., Lopez I., et al. Nutritional secondary hyperparathyroidism in rabbits. Domest Anim Endocrinol 28 (2005) 380-390
84. Mehrotra M., Gupta S.K., Kumar K., et al. Calcium deficiency-induced secondary hyperparathyroidism and osteopenia are rapidly reversible with calcium supplementation in growing rabbit pups. Br J Nutr 95 (2006) 582-590
85. Norris S.A., Pettifor J.M., Gray D.A., et al. Calcium metabolism and bone mass in female rabbits during skeletal maturation: effects of dietary calcium intake. Bone 29 1 (2001) 62-69
86. Gilsanz V., Roe T.F., Antunes J., et al. Effect of dietary calcium on bone density in growing rabbits. Am J Physiol 260 Endocrinol Metab 23 (1991) E471-E476
87. Pare J.A., and Paul-Murphy J. Disorders of reproductive and urinary systems. In: Quesenbery K.E., and Carpenter J.W. (Eds). Ferrets, rabbits and rodents: clinical medicine and surgery. 2nd edition (2003), WB Saunders, Philadelphia 183-193
88. Fisher P.G. Exotic mammal renal disease: causes and clinical presentation. Vet Clin North Am Exot Anim Pract 9 1 (2001) 33-67
89. Cheeke P.R. Rabbit feeding and nutrition (1987), Academic Press, Orlando (FL) p. 106-11, 144-5, 336
90. Chapin R.E., and Smith S.E. The calcium tolerance of growing and reproducing rabbits. Cornell Vet 57 (1967) 480-491
91. Chapin R.E., and Smith S.E. Calcium requirement of growing rabbits. J Anim Sci 26 (1967) 67-71
92. Lowe J.A. Pet rabbit feeding and nutrition. In: Blas C., and Wiseman J. (Eds). The nutrition of the rabbit (1998), CABI Publishing, Cambridge (MA) 304-331