The Crystal Structures of Ornithine Carbamoyltransferase from Mycobacterium tuberculosis and Its Ternary Complex with Carbamoyl Phosphate and l-Norvaline Reveal the Enzyme's Catalytic Mechanism

Journal of Molecular Biology

Volumn 375, Issue 4, 2008, Pages 1052-1063

  Sankaranarayanan, Ramasamy ^a   Cherney, Maia M ^a   Cherney, Leonid T ^a   Garen, Craig R ^a   Moradian, Fatemeh ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

carbamoyl phosphate; crystal structure; Mycobacterium tuberculosis; norvaline; ornithine carbamoyltransferase

Indexed keywords

ARGININE; CARBAMOYL PHOSPHATE; CITRULLINE; CYSTEINE; LIGAND; NORVALINE; ORNITHINE; ORNITHINE CARBAMOYLTRANSFERASE; PHOSPHATE;

ARTICLE; BIOSYNTHESIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REDUCTION;

MYCOBACTERIUM TUBERCULOSIS;

EID: 37449003424     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.11.025     Document Type: Article

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