Radioprotective effects of 2-(allylthio)pyrazine an experimental chemopreventive agent: Effects on detoxifying enzyme induction

Research Communications in Molecular Pathology and Pharmacology

Volumn 101, Issue 3, 1998, Pages 275-288

  Kim, Sang Geon ^a   Nam, Seon Young ^a   Kim, Choon Won ^b   Cho, Chul Koo ^c   Kim, Nak Doo ^d  

^a Duksung Women's University   (South Korea)

^b Hanyang University   (South Korea)

^c Korea Atomic Energy Research Institute   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ALLYLTHIO)PYRAZINE; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CHEMICAL STRUCTURE; CHEMOPROPHYLAXIS; DETOXIFICATION; ENZYME ACTIVATION; GAMMA RADIATION; GENE EXPRESSION; IONIZING RADIATION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RADIATION PROTECTION; RAT;

ANIMALS; ENZYME INDUCTION; ENZYME INHIBITORS; EPOXIDE HYDROLASES; GLUTATHIONE TRANSFERASE; LIVER; MALE; MICE; MICE, INBRED ICR; PYRAZINES; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 3743091529     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ansher, S. S., Dolan, P. and Bueding, E. (1983) Chemoprotective effects of two dithiolthiones and butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity. Hepatology 3: 932-935.
2. Bammler, T. K., Smith, C. A. D. and Wolf, C. R. (1994) Isolation and characterization of two mouse Pi-class glutathione S-transferase genes. Biochem. J. 298: 385-390.
3. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
4. Daniel, V. (1993) Glutathione S-transferases: gene structure and regulation of expression. Crit. Rev. Biochem. Mol. Biol. 28: 173-207.
5. Ding, G. J. F., Lu, A. Y. H. and Pickett, C. B. (1985) Rat liver glutathione S-transferases: nucleotide sequence analysis of a Yb1 cDNA clone and prediction of the complete amino acid sequence of the Yb1 subunit. J. Biol. Chem. 260: 13268-13271.
6. Ding, G. J. F., Ding, V. D. H., Rodkey, J. A., Bennett, C. D., Lu, A. Y. H. and Pickett, C. B. (1986) Rat liver glutathione S-transferases: DNA sequence analysis of a Yb2 cDNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital. J. Biol. Chem. 261: 7952-7957.
7. Hayes, J. D., Nguyen, T., Judah, D. J., Petersson, D. G. and Neal, G. E. (1994) Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. J. Biol. Chem. 269: 20707-20717.
8. Hayes, J. D., Judah, D. J., Neal, G. E. and Nguyen, T. (1992) Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide. Biochem. J. 285: 173-180.
9. Hayes, J. D. and Pulford, D. J. (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30: 445-600.
10. Kim, N. D., Kim, S. G. and Kwak, M. K. (1994) Enhanced expression of rat microsomal epoxide hydrolase gene by organosulfur compounds. Biochem Pharmacol 47: 541-547.
11. Kim, N. D., Kwak, M. K. and Kim, S. G. (1997a) Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects. Biochem. Pharmacol. 53: 261-269.
12. Kim, S. G., Chung, H. C. and Cho, J. Y. (1996) Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: the role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression. J. Pharmacol. Exp. Therap. 277: 1058-1066.
13. Kim, S. G., Nam, S. Y., Kim, J. H., Cho, C. K. and Yoo, S. Y. (1997b) Enhancement of radiation-inducible hepatic glutathione S-transferase Ya, Yb1, Yb2, Yc1, and Yc2 expression by oltipraz: possible role in radioprotection. Mol. Phamacol. 51: 225-233.
14. Kim, S. G., Nam, S. Y. and Kim, C. W. (1998a) In vivo radioprotective effects of oltipraz in γ-irradiated mice. Biochem. Pharmacol. 55: 1585-1590.
15. Kim, S. G., Lee, A. K. and Kim, N. D. (1998b) Partial hepatoprotective effects of allylthiobenzimidazole in the absence of cytochrome P450 2E1 suppression: effects on epoxide hydrolase, rGSTA2, rGSTA3/5, rGSTM1 and rGSTM2 expression. Xenobiotica 28: 323-336.
16. Kim, S. G. (1992) Transcriptional regulation of rat microsomal epoxide hydrolase gene by imidazole antimycotic agents. Mol. Pharmacol. 42: 273-279.
17. Kim, S. G. and Kim, Y. H. (1992) Gender-related expression of rat microsomal epoxide hydrolase during maturation: post-transcriptional regulation. Mol. Pharmacol. 42: 75-81.
18. Kim, S. G. and Novak, R. F. (1993) The induction of cytochrome P450 2E1 by nitrogen-and sulfur-containing heterocycles: expression and molecular regulation. Toxicol. Appl. Pharmacol. 120: 257-265.
19. Nam, S. Y., Kim, J. H., Cho, C. K., Yoo, S. Y. and Kim, S. G. (1997) Oltipraz enhancement of radiation-induced hepatic microsomal epoxide hydrolase gene expression in rats. Radiat. Res. 147: 613-620.
20. Nam, S. Y., Cho, C. K. and Kim, S. G. (1998) Supression of radiation-inducible microsomal epoxide hydrolase and glutathione S-transferase gene expression by dexamethasone correlates with the increased mortality: effects on vitamin C and E-induced radioprotection. Biochem. Pharmacol. in press.
21. Pickett, C. B., Telakowski-Hopkins, C. A., Ding, G. J. F., Argenbright, L. and Lu, A. Y. H. (1984) Rat liver glutathione S-transferases: complete nucleotide sequence of a glutathione S-transferases mRNA and the regulation of the Ya, Yb and Yc mRNAs by 3-methylcholanthrene and phenobarbital. J. Biol. Chem. 259: 5182-5188.
22. Puissant, C. and Houdebine, L. M. (1990) An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Biotechniques 8:148-149.
23. Roebuck, B. D., Liu, Y. L., Rogers, A. E., Groopman, J. D. and Kensler, T. W. (1991) Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Res 51: 5501-5506,.
24. Schor, N. F., Siuda, J. F., Lomis, T. J. and Cheng, B. (1990) Structural studies on the motivation of γ-glutamylcysteine synthetase by the disulphide analogues of radioprotective cysteamine derivatives. Biochem. J. 267: 291-296.
25. Surh, Y.J., Kim, S. G., Park, K. K., Sohn, Y., Lee, J. M., Kim, N. D. and Miller, J. A. (1998) Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide. Carcinogenesis 19: 1263-1268.
26. Teicher, B. A., Stemwedel, J., Herman, T. S., Ghoshal, P. K. and Rosowsky, A. (1990) 1,2-Dithiol-3-thione and dithioester analogues: potential radioprotectors. Br. J. Cancer 62: 17-22.
27. Tubiana, M., Dutreix, J. and Wambersie, A. (1990) Introduction to radiobiology, pp.1-33. Taylor & Francis, New York.