A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes

Microbial Pathogenesis

Volumn 44, Issue 2, 2008, Pages 159-163

  Orgun, Nural N ^a   Way, Sing Sing ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Bacteria; T cell immunity; Vaccine

Indexed keywords

LISTERIOLYSIN O; PHOSPHOLIPASE C;

ARTICLE; BACTERIAL IMMUNITY; BACTERIAL INFECTION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BACTERIAL VACCINES; COLONY COUNT, MICROBIAL; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LIVER; MICE; MICE, INBRED C57BL; SPLEEN; TYPE C PHOSPHOLIPASES; VACCINES, ATTENUATED;

BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES;

EID: 37349120020     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2007.08.002     Document Type: Article

References (19)

1. Hamon M., Bierne H., and Cossart P. Listeria monocytogenes: a multifaceted model. Nat Rev Microbiol 4 (2006) 423-434
2. Pamer E.G. Immune responses to Listeria monocytogenes. Nat Rev Immunol 4 (2004) 812-823
3. Sun J.C., Williams M.A., and Bevan M.J. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol 5 (2004) 927-933
4. Sun J.C., and Bevan M.J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300 (2003) 339-342
5. Shedlock D.J., and Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300 (2003) 337-339
6. Harty J.T., and Bevan M.J. CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo. J Exp Med 175 (1992) 1531-1538
7. O'Riordan M., Yi C.H., Gonzales R., Lee K.D., and Portnoy D.A. Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc Natl Acad Sci U S A 99 (2002) 13861-13866
8. Brzoza K.L., Rockel A.B., and Hiltbold E.M. Cytoplasmic entry of Listeria monocytogenes enhances dendritic cell maturation and T cell differentiation and function. J Immunol 173 (2004) 2641-2651
9. McCaffrey R.L., Fawcett P., O'Riordan M., Lee K.D., Havell E.A., Brown P.O., et al. A specific gene expression program triggered by Gram-positive bacteria in the cytosol. Proc Natl Acad Sci USA 101 (2004) 11386-11391
10. Berche P., Gaillard J.L., and Sansonetti P.J. Intracellular growth of Listeria monocytogenes as a prerequisite for in vivo induction of T cell-mediated immunity. J Immunol 138 (1987) 2266-2271
11. Brunt L.M., Portnoy D.A., and Unanue E.R. Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth. J Immunol 145 (1990) 3540-3546
12. Bahjat K.S., Liu W., Lemmens E.E., Schoenberger S.P., Portnoy D.A., Dubensky Jr. T.W., et al. Cytosolic entry controls CD8+-T-cell potency during bacterial infection. Infect Immun 74 (2006) 6387-6397
13. Hamilton S.E., Badovinac V.P., Khanolkar A., and Harty J.T. Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity. J Immunol 177 (2006) 4012-4020
14. Brundage R.A., Smith G.A., Camilli A., Theriot J.A., and Portnoy D.A. Expression and phosphorylation of the Listeria monocytogenes actA protein in mammalian cells. Proc Natl Acad Sci USA 90 (1993) 11890-11894
15. Orr M.T., Orgun N.N., Wilson C.B., and Way S.S. Cutting edge: recombinant Listeria monocytogenes expressing a single immune-dominant peptide confers protective immunity to herpes simplex virus-1 infection. J Immunol 178 (2007) 4731-4735
16. Mercado R., Vijh S., Allen S.E., Kerksiek K., Pilip I.M., and Pamer E.G. Early programming of T cell populations responding to bacterial infection. J Immunol 165 (2000) 6833-6839
17. Barry R.A., Bouwer H.G., Portnoy D.A., and Hinrichs D.J. Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread. Infect Immun 60 (1992) 1625-1632
18. Muraille E., Giannino R., Guirnalda P., Leiner I., Jung S., Pamer E.G., et al. Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes. Eur J Immunol 35 (2005) 1463-1471
19. Jung S., Unutmaz D., Wong P., Sano G., De los Santos K., Sparwasser T., et al. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17 (2002) 211-220