Litomosoides sigmodontis: Vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection

Experimental Parasitology

Volumn 118, Issue 2, 2008, Pages 285-289

  Lamb, Tracey J ^a   Harris, Anjanette ^a   Le Goff, Laetitia ^a   Read, Andrew F ^a   Allen, Judith E ^a  

^a Institute of Immunology and Infection Research   (United Kingdom)

Author keywords

Alum; Antibody; Antibody isotype; CFA; Complete Freund's Adjuvant; Endosymbiont; Female; Filarial nematode; Filariasis; Helminth; Litomosoides sigmodontis; Litomosoides sigmodontis Wolbachia surface protein; LsWSP; Male; Nematode; Th1 Th2; Type 1 response; Wolbachia; Wolbachia surface protein

Indexed keywords

ALUM VACCINE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; MEMBRANE PROTEIN; PARASITE VACCINE; UNCLASSIFIED DRUG; VACCINE;

ARTICLE; DISEASE MODEL; FILARIA; FILARIASIS; IMMUNE RESPONSE; IMMUNIZATION; LITOMOSOIDES SIGMODONTIS; MERIONES UNGUICULATUS; NEMATODE; NONHUMAN; ORNOTHONYSSUS BACOTI; PARASITE; PARASITE SURVIVAL; PARASITOSIS; PRIMARY INFECTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; VACCINATION; WOLBACHIA;

ANALYSIS OF VARIANCE; ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; CYTOKINES; FEMALE; FILARIASIS; FILARIOIDEA; IMMUNOGLOBULIN G; MALE; MICE; MICE, INBRED BALB C; SYMBIOSIS; VACCINATION; WOLBACHIA;

LITOMOSOIDES SIGMODONTIS; MAMMALIA; NEMATODA; RODENTIA; VERMES; WOLBACHIA;

EID: 37349116238     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2007.08.011     Document Type: Article

References (23)

1. Allen J.E., Lawrence R.A., and Maizels R.M. Fine specificity of the genetically controlled immune response to native and recombinant gp15/400 (polyprotein allergen) of Brugia malayi. Infection and Immunity 63 (1995) 2892-2898
2. Babu S., Porte P., Klei T.R., Shultz L.D., and Rajan T.V. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. Journal of Immunology 161 (1998) 1428-1432
3. Bandi C., Anderson T.J., Genchi C., and Blaxter M.L. Phylogeny of Wolbachia in filarial nematodes. Proceedings of the Royal Society London B Biological Sciences 265 (1998) 2407-2413
4. Brattig N.W., Buttner D.W., and Hoerauf A. Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria. Microbes and Infection 3 (2001) 439-446
5. Brattig N.W., Bazzocchi C., Kirschning C.J., Reiling N., Buttner D.W., Ceciliani F., Geisinger F., Hochrein H., Ernst M., Wagner H., Bandi C., and Hoerauf A. The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. Journal of Immunology 173 (2004) 437-445
6. Brewer J.M., Conacher M., Satoskar A., Bluethmann H., and Alexander J. In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production. European Journal of Immunology 26 (1996) 2062-2066
7. Casiraghi M., Bain O., Guerrero R., Martin C., Pocacqua V., Gardner S.L., Franceschi A., and Bandi C. Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution. International Journal of Parasitology 34 (2004) 191-203
8. DeKruyff R.H., Mosmann R.R., and Umetsu D.T. Induction of antibody synthesis by CD4+ T cells: IL 5 is essential for induction of antigen-specific antibody responses by TH2 but not TH1 clones. European Journal of Immunology 20 (1990) 2219-2227
9. Fenn K., and Blaxter M. Quantification of Wolbachia bacteria in Brugia malayi through the nematode lifecycle. Molecular and Biochemical Parasitology 137 (2004) 361-364
10. Fischer P., Bonow I., Buttner D.W., Kamal I.H., and Liebau E. An aspartate aminotransferase of Wolbachia endobacteria from Onchocerca volvulus is recognized by IgG1 antibodies from residents of endemic areas. Parasitology Research 90 (2003) 38-47
11. Grafen A., and Halls R. Modern Statistics for the Life Sciences (2002), Oxford University Press
12. Hise A.G., Daehnel K., Gillette-Ferguson I., Cho E., McGarry H.F., Taylor M.J., Golenbock D.T., Fitzgerald K.A., Kazura J.W., and Pearlman E. Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. Journal of Immunology 178 (2007) 1068-1076
13. Hoerauf A. New strategies to combat filariasis. Expert Review of Anti-infective Therapy 4 (2006) 211-222
14. Lamb T.J., Le Goff L., Kurniawan A., Guiliano D.B., Fenn K., Blaxter M.L., Read A.F., and Allen J.E. The majority of the response elicited against Wolbachia surface protein in filarial nematode infection in due to the infective larval stage. Journal of Infectious Diseases 189 (2004) 120-127
15. Le Goff L., Lamb T.J., Graham A.L., Harcus Y., and Allen J.E. IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. International Journal of Parasitology 32 (2002) 1277-1284
16. McGarry H.F., Egerton G.L., and Taylor M.J. Population dynamics of Wolbachia bacterial endosymbionts in Brugia malayi. Molecular and Biochemical Parasitology 135 (2004) 57-67
17. McLaren D.J., Worms M.J., Laurence B.R., and Simpson M.G. Micro-organisms in filarial larvae (Nematoda). Transactions of the Royal Society of Tropical Medicine Hygiene 69 (1975) 509-514
18. Pfarr K.M., Fischer K., and Hoerauf A. Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis. Medical Microbiology & Immunology (Berlin) 192 (2003) 53-56
19. Punkosdy G.A., Addiss D.G., and Lammie P.J. Characterization of antibody responses to Wolbachia surface protein in humans with lymphatic filariasis. Infection and Immunity 71 (2003) 5104-5114
20. Ravindran B. Are inflammation and immunological hyperactivity needed for filarial parasite development?. Trends in Parasitology 17 (2001) 70-73
21. Snapper C.M., and Paul W.E. B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide. Journal of Immunology 139 (1987) 10-17
22. Suba N., Shiny C., Taylor M.J., and Narayanan R.B. Brugia malayi Wolbachia hsp60 IgG antibody and isotype reactivity in different clinical groups infected or exposed to human bancroftian lymphatic filariasis. Experimental Parasitology 116 (2007) 291-295
23. Volkmann L., Bain O., Saeftel M., Specht S., Fischer K., Brombacher F., Matthaei K.I., and Hoerauf A. Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages. Medical Microbiology & Immunology (Berlin) 192 (2003) 23-31