Plant-derived EpCAM antigen induces protective anti-cancer response

Cancer Immunology, Immunotherapy

Volumn 57, Issue 3, 2008, Pages 317-323

  Brodzik, Robert ^a   Spitsin, Sergei ^a   Golovkin, Max ^a   Bandurska, Katarzyna ^a   Portocarrero, Carla ^a   Okulicz, Monika ^b   Steplewski, Zenon ^a   Koprowski, Hilary ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Colorectal cancer; Plant biotechnology; Recombinant subunit vaccine

Indexed keywords

EPITHELIAL CELL ADHESION MOLECULE; MONOCLONAL ANTIBODY; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PURIFICATION; ANTIGENICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACULOVIRUS; BAGG ALBINO MOUSE; CANCER CELL; CANCER INHIBITION; COLORECTAL CANCER; CONTROLLED STUDY; FEASIBILITY STUDY; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SERUM; XENOGRAFT;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; BETA VULGARIS; CANCER VACCINES; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; GENE EXPRESSION REGULATION, PLANT; HUMANS; IMMUNE SERA; IMMUNOTHERAPY; MICE; MICE, INBRED BALB C; MICE, NUDE; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; TOBACCO; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 37349104921     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-007-0366-4     Document Type: Article

References (26)

1. Armstrong A, Eck SL (2003) EpCAM: a new therapeutic target for an old cancer antigen. Cancer Biol Ther 2:320-326
2. Boehm R (2007) Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann N Y Acad Sci 1102:121-134
3. Brady LJ (2005) Antibody-mediated immunomodulation: a strategy to improve host responses against microbial antigens. Infect Immune 73:671-678
4. Brodzik R, Bandurska K, Deka D, Golovkin M, Koprowski H (2005) Advances in alfalfa mosaic virus-mediated expression of anthrax antigen in planta. Biochem Biophys Res Commun 338(2):717-722
5. Brodzik R, Glogowska M, Bandurska K et al (2006) Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells. Proc Natl Acad Sci USA 103:8804-8809
6. Choudhury A, Mosolits S, Kokhaei P et al (2006) Clinical results of vaccine therapy for cancer: learning from history for improving the future. Adv Cancer Res 95:147-202
7. Dalgleish AG, Whelan MA (2006) Cancer vaccines as a therapeutic modality: the long trek. Cancer Immunol Immunother 55:1025-1032
8. Emens LA (2006) Roadmap to a better therapeutic tumor vaccine. Int Rev Immunol 25:415-443
9. Fox JL (2006) Turning plants into protein factories. Nat Biotechnol 24:1191-1193
10. Gleba Y, Klimyuk V, Marillonnet S (2005) Magnifection-a new platform for expressing recombinant vaccines in plants. Vaccine 23:2042-2048
11. Gleba Y, Klimyuk V, Marillonnet S (2007) Viral vectors for the expression of proteins in plants. Curr Opin Biotechnol 18(2):134-141
12. Goldstein DA, Thomas JA (2004) Biopharmaceuticals derived from genetically modified plants. Q J Med 97:705-716
13. Golovkin M, Spitsin S, Andrianov V et al (2007) Smallpox subunit vaccine produced in planta confers protection in mice. Proc Natl Acad Sci USA 104(16):6864-6869
14. Hodge JW, Greiner JW, Tsang KY et al (2006) Costimulatory molecules as adjuvants for immunotherapy. Front Biosci 11:788-803
15. Ko K, Steplewski Z, Glogowska M, Koprowski H (2005) Inhibition of tumor growth by plant-derived mAb. Proc Natl Acad Sci USA 19:7026-7030
16. Koprowski H (2005) Vaccines and sera through plant biotechnology. Vaccine 23:1757-1763
17. Ma JK-C, Chikwamba R, Sparrow P, Fischer R, Mahoney R, Twyman RM (2005) Plant-derived pharmaceuticals-the road forward. Trends in Plant Sci 10:580-585
18. Marillonnet S, Giritch A, Gils M, Kandzia R, Klimyuk V, Gleba Y (2004) In planta engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc Natl Acad Sci USA 101:6852-6857
19. Mosolits S, Markovic K, Frodin JE, Virving L et al (2004) Vaccination with Ep-CAM protein or anti-idiotypic antibody induces Th1-biased response against MHC class I- and II-restricted Ep-CAM epitopes in colorectal carcinoma patients. Clin Cancer Res 10:5391-5402
20. Mosolits S, Nilsson B, Mellstedt H (2005) Towards therapeutic vaccines for colorectal carcinoma: a review of clinical trials. Expert Rev Vaccines 4:329-350
21. Nagorsen D, Thiel E (2006) Clinical and immunologic responses to active specific cancer vaccines in human colorectal cancer. Clin Cancer Res 12:3064-3069
22. Neidhart J, Allen KO, Barlow DL et al (2004) Immunization of colorectal cancer patients with recombinant baculovirus-derived KSA (Ep-CAM) formulated with monophosphoryl lipid A in liposomal emulsion, with and without granulocyte-macrophage colony-stimulating factor. Vaccine 22:773-780
23. Pogrebnyak N, Golovkin M, Andrianov V et al (2005) Severe acute respiratory syndrome (SARS) S protein production in plants: development of recombinant vaccine. Proc Natl Acad Sci USA 102:9062-9067
24. Staib L, Birebent B, Somasundaram R et al (2001) Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients. Int J Cancer 92:79-87
25. Szala S, Froehlich M, Scollon M et al (1990) Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2. Proc Natl Acad Sci USA 87:3542-3546
26. Verch T, Hooper DC, Kiyatkin A, Steplewski Z, Koprowski H (2004) Immunization with a plant-produced colorectal cancer antigen. Cancer Immunol Immunother 53:92-99