Effects of ovine CRF injections into the dorsomedial, dorsolateral and lateral columns of the periaqueductal gray: A functional role for the dorsomedial column

Hormones and Behavior

Volumn 53, Issue 1, 2008, Pages 40-50

  Borelli, Karina G ^a   Brandão, Marcus L ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anxiety; Dorsomedial column of the PAG; Elevated plus maze; Fear; oCRF

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR; OVINE CORTICOTROPIN RELEASING FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIORAL SCIENCE; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FUNCTIONAL ANATOMY; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; LATERAL GENICULATE BODY; MALE; MAZE TEST; MICROINJECTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; THALAMUS DORSOMEDIAL NUCLEUS;

ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; CORTICOTROPIN-RELEASING HORMONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; MALE; MAZE LEARNING; MICROINJECTIONS; MOTOR ACTIVITY; ORGAN SPECIFICITY; PERIAQUEDUCTAL GRAY; RATS; RATS, WISTAR; SHEEP;

EID: 37349088117     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2007.08.013     Document Type: Article

References (79)

1. Albrechet-Souza L., Carvalho M.C., Franci C.R., and Brandão M.L. Increases in plasma corticosterone and stretched-attend postures in rats naive and previously exposed to the elevated plus-maze are sensitive to the anxiolytic-like effects of midazolam. Horm. Behav. 52 (2007) 267-273
2. Anseloni V.C.Z., and Brandão M.L. Ethopharmacological analysis of behaviour of rats using variations of the elevated plus-maze. Behav. Pharmacol. 8 (1997) 533-540
3. Arborelius L., Owens M.J., Plotsky P.M., and Nemeroff C.B. The role of corticotropin-releasing factor in depression and anxiety disorders. J. Endocrinol. 60 (1999) 1-12
4. Bagri A., Di Scala G., and Sandner G. Wild running elicited by microinjections of bicuculline or morphine into the inferior colliculus of rats: lack of effect of periaqueductal gray lesions. Pharmacol. Biochem. Behav. 41 (1992) 727-732
5. Bandler R., and Carrive P. Integrated defence reaction elicited by excitatory amino acid microinjection in the midbrain periaqueductal grey region of the unrestrained cat. Brain Res. 439 (1988) 95-106
6. Bandler R., and Shipley M.T. Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?. Trends Neurosci. 17 (1994) 379-389
7. Bandler R., and Keay K.A. Columnar organization in the midbrain periaqueductal gray and the integration of emotional expression. Prog. Brain Res. 107 (1996) 285-300
8. Bandler R., Depaulis A., and Vergnes M. Identification of midbrain neurons mediating defensive behaviour in the rat by microinjections of excitatory amino acids. Behav. Brain Res. 15 (1985) 107-119
9. Behbehani M.M. Functional characteristics of the midbrain periaqueductal gray. Prog. Eurobiol. 46 (1995) 575-605
10. Blanchard D.C., Williams G.E.M.L., and Blanchard R.J. Taming of wild Rattus norvegicus by lesions of the mesencephalic central gray. Physiol. Behav. 9 (1981) 157-163
11. Blanchard R.J., Yudko E.B., Rodgers R.J., and Blanchard D.C. Defense system psychopharmacology: an ethological approach to the pharmacology of fear and anxiety. Behav. Brain Res. 58 (1993) 155-165
12. Blanchard D.C., Canteras N.S., Markham C.M., Pentkowski N.S., and Blanchard R.J. Lesions of structures showing Fos expression to cat presentation: effects on responsivity to a Cat, Cat odor, and nonpredator threat. Neurosci. Biobehav. Rev. 29 (2005) 1243-1253
13. Borelli K.G., Ferreira-Netto C., and Brandão M.L. Fos-like immunoreactivity in the brain associated with freezing or escape induced by inhibition of either glutamic acid decarboxylase or GABAA receptors in the dorsal periaqueductal gray. Brain Res. 105 (2005) 100-111
14. Borelli K.G., Ferreira-Netto C., and Brandão M.L. Distribution of Fos immunoreactivity in the rat brain after freezing or escape elicited by inhibition of glutamic acid decarboxylase or antagonism of GABA-A receptors in the inferior colliculus. Behav. Brain Res. 170 (2006) 84-93
15. Bowers L.K., Swisher C.B., and Behbehani M.M. Membrane and synaptic effects of corticotropin-releasing factor on periaqueductal gray neurons of the rat. Brain Res. 981 (2003) 52-57
16. Brandão M.L., de Aguiar J.C., and Graeff F.G. GABA mediation of the antiaversive action of minor tranquilizers. Pharmacol. Biochem. Behav. 16 (1982) 397-402
17. Brandão M.L., Tomaz C., Borges P.C., Coimbra N.C., and Bagri A. Defense reaction induced by microinjections of bicuculline into the inferior colliculus. Physiol. Behav. 4 (1988) 361-365
18. Brandão M.L., Coimbra N.C., and Borges P.C. Effects of morphine and midazolam on reactivity to peripheral noxious and central aversive stimuli. Neurosci. Biobehav. Rev. 14 (1990) 495-499
19. Brandão M.L., Cardoso S.H., and Melo L.L. Defense mechanisms in the inferior colliculus. Behav. Brain Res. 58 (1993) 49-55
20. Brandão M.L., Anseloni V.Z., Pandossio J.E., De Araujo J.E., and Castilho V.M. Neurochemical mechanisms of the defensive behavior in the dorsal midbrain. Neurosci. Biobehav. Rev. 23 (1999) 863-875
21. Brandão M.L., Borelli K.G., Nobre M.J., Santos J.M., Albrechet-Souza L., Oliveira A.R., and Martinez R.C. GABAergic regulation of the neural organization of fear in the midbrain tectum. Neurosci. Biobehav. Rev. 29 (2005) 1299-1311
22. Canteras N.S., and Goto M. Fos-like immunoreactivity in the periaqueductal gray of rats exposed to a natural predator. NeuroReport 10 (1999) 413-418
23. Canteras N.S., Chiavegatto S., Valle L.E., and Swanson L.W. Severe reduction of rat defensive behavior to a predator by discrete hypothalamic chemical lesions. Brain Res. Bull. 44 (1997) 297-305
24. Cardoso S.H., Coimbra N.C., and Brandão M.L. Defensive reactions evoked by activation of NMDA receptors in distinct sites of the inferior colliculus. Behav. Brain Res. 63 (1994) 17-24
25. Carrive P. Functional organization of PAG neurons controlling regional vascular beds. In: Bandler R., and Depaulis A. (Eds). The Midbrain Periaqueductal Grey Matter: Functional, Anatomical and Immunohistochemical Organization (1991), Plenum Press, New York 67-100
26. Carrive P. The periaqueductal gray and defensive behavior: functional representation and neuronal organization. Behav. Brain Res. 58 (1993) 27-47
27. Carrive P., and Bandler R. Viscerotopic organization of neurons subserving hypotensive reactions within the midbrain periaqueductal grey: a correlative functional and anatomical study. Brain Res. 15 (1991) 206-215
28. Carvalho-Netto E.F., Litvin Y., Nunes-De-Souza R.L., Blanchard D.C., and Blanchard R.J. Effects of intra-PAG infusion of ovine CRF (oCRF) on defensive behaviors in Swiss-Webster mice. Behav. Brain Res. 176 (2007) 222-229
29. Castilho V.M., and Brandão M.L. Conditioned antinociception and freezing using electrical stimulation of the dorsal periaqueductal gray or inferior colliculus as unconditioned stimulus are differentially regulated by 5-HT2A receptors in rats. Psychopharmacology 155 (2001) 154-162
30. Coimbra N.C., and Brandão M.L. GABAergic nigro-collicular pathways modulate the defensive behaviour elicited by midbrain tectum stimulation. Behav. Brain Res. 31 (1993) 131-139
31. Coimbra N.C., and Brandão M.L. Effects of 5-HT2 receptors blockade on fear induced analgesia elicited by electrical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray. Behav. Brain Res. 87 (1997) 97-103
32. Coimbra N.C., Tomaz C., and Brandão M.L. Evidence for the involvement of erotonin in the antinociception induced by electrical or chemical stimulation of the mesencephalic tectum. Behav. Brain Res. 50 (1992) 77-83
33. Coimbra C., De Oliveira R., Freitas R.L., Ribeiro R.J., Borelli K.G., Pacagnella R.C., Moreira J.E., Da Silva L.A., Mello L.L., Lunardi L.O., and Brandão M.L. Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the superior colliculus and periaqueductal gray matter involved in the elaboration of the defensive behavior and fear-induced analgesia. Exp. Neurol. 197 (2006) 93-112
34. Comoli E., Ribeiro-Barbosa E.R., and Canteras N.S. Predatory hunting and exposure to a live predator induce opposite patterns of Fos immunoreactivity in the PAG. Behav. Brain Res. 138 (2003) 17-28
35. Cruz A.P., Frei F., and Graeff F.G. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol. Biochem. Behav. 49 (1994) 171-176
36. De Luca M.C.V., Macedo C.E., and Brandão M.L. Pharmacological assessment of the freezing, antinociception, and exploratory behavior organized in the ventrolateral periaqueductal gray. Pain 121 (2006) 94-110
37. De Souza E.B. Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution. J. Neurosci. 7 (1987) 88-100
38. De Souza E.B. Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology 20 (1995) 789-819
39. De Souza E.B., Insel T.R., Perrin M.H., Rivier J., Vale W.W., and Kuhar M.J. Corticotropin-releasing factor receptors are widely distributed within the rat CNS: an autoradiographic study. J. Neurosci. 5 (1985) 3189-3203
40. Dunn A.J., and Berridge C.W. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?. Brain Res. Brain Res. Rev. 15 (1990) 71-100
41. Fanselow M.S. The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety. In: Bandler R., and Depaulis A. (Eds). The Midbrain Periaqueductal Grey Matter: Functional, Anatomical and Immunohistochemical Organization (1991), Plenum Press, New York 151-173
42. Ferreira-Netto C., and Guimarães F.S. Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray. Neuropsychopharmacology 29 (2004) 101-107
43. Ferreira-Netto C., Borelli K.G., and Brandão M.L. Distinct Fos expression in the brain following freezing behavior elicited by stimulation with NMDA of the ventral or dorsal inferior colliculus. Exp. Neurol. 204 (2007) 693-704
44. File S.E., Zangrossi H., Sanders F.L., and Mabbutt P.S. Raised corticosterone in the rat after exposure to the elevated plus-maze. Psychopharmacology 113 (1994) 543-546
45. Fisher L.A. Central actions of corticotropin-releasing factor on autonomic nervous activity and cardiovascular functioning. Ciba Found Symp. 172 (1993) 243-253
46. Gomita Y., Moriyama M., Ichimaru Y., and Araki Y. Neural systems activated by the aversive stimulation of dorsal central gray. Jpn. J. Pharmacol. 48 (1988) 137-141
47. Graeff F.G. Serotonin, the periaqueductal gray and panic. Neurosci. Biobehav. Rev. 28 (2004) 239-259
48. Graeff F.G., Viana M.B., and Mora P.O. Dual role of 5-HT in defense and anxiety. Neurosci. Biobehav. Rev. 21 (1997) 791-799
49. Gray T.S., and Magnuson D.J. Peptide immunoreactive neurons in the amygdala and the bed nucleus of the stria terminalis project to the midbrain central gray in the rat. Peptides 13 (1992) 451-460
50. Griebel G. Is there a future for neuropeptide receptor ligands in the treatment of anxiety disorders?. Pharmacol. Ther. 82 (1999) 1-61
51. Hauger R.L., Grigoriadis D.E., Dallman M.F., Plotsky P.M., Vale W.W., and Dautzenberg F.M. International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. Pharmacol. Rev. 55 (2003) 21-26
52. Hayward L.F., Swartz C.L., and Davenport P.W. Respiratory response to activation or disinhibition of the dorsal periaqueductal gray in rats. J. Appl. Physiol. 94 (2003) 913-922
53. Jenck F., Schmitt P., and Karli P. Morphine injected into the periaqueductal gray attenuates brain stimulation-induced effects: an intensity discrimination study. Brain Res. 378 (1986) 274-284
54. Koob G.F., Heinrichs S.C., Pich E.M., Menzagli F., Baldwin H., Miczek K., and Britton K.T. The role of corticotropin-releasing factor in behavioural responses to stress. Ciba Found. Symp. 172 (1993) 277-289
55. Litvin Y.S., Pentkowski N., Blanchard C.D., and Blanchard R.J. CRF type 1 receptors in the dorsal periaqueductal gray modulate anxiety-induced defensive behaviors. Horm. Behav. 52 (2007) 244-251
56. Martins A.P., Marras R.A., and Guimarães F.S. Anxiogenic effect of corticotropin-releasing hormone in the dorsal periaqueductal grey. NeuroReport 8 (1997) 3601-3604
57. Martins A.P., Marras R.A., and Guimarães F.S. Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray. Depress. Anxiety 12 (2000) 99-101
58. Melo L.L., and Brandão M.L. Role of 5-HT1A and 5-HT2 receptors in the aversion induced by electrical stimulation of inferior colliculus. Pharmacol. Biochem. Behav. 51 (1995) 317-321
59. Melo L.L., Cardoso S.H., and Brandão M.L. Antiaversive action of benzodiazepines on escape behavior induced by electrical stimulation of the inferior colliculus. Physiol. Behav. 51 (1992) 557-562
60. Merchenthaler I. Corticotropin releasing factor (CRF)-like immunoreactivity in the rat central nervous system. Extrahypothalamic distribution. Peptides 5 (1984) 53-69
61. Mikics E., Barsy B., Barsvari B., and Haller J. Behavioral specificity of non-genomic glucocorticoid effects in rats: effects on risk assessment in the elevated plus-maze and the open-field. Horm. Behav. 48 (2005) 152-162
62. Momose K., Inui A., Asakawa A., Ueno N., Nakajima M., Fujimiya M., and Kasuga M. Intracerebroventricularly administered corticotropin-releasing factor inhibits food intake and produces anxiety-like behaviour at very low doses in mice. Diabetes Obes. Metab. 1 (1999) 281-284
63. Morgan M.M., and Carrive P. Activation of the ventrolateral periaqueductal gray reduces locomotion but not mean arterial pressure in awake, freely moving rats. Neuroscience 102 (2001) 905-910
64. Nobre M.J., Lopes M.G., and Brandão M.L. Defense reaction mediated by NMDA mechanisms in the inferior colliculus is modulated by GABAergic nigro-collicular pathways. Brain Res. 27 (2004) 124-131
65. Osaki M.Y., Castellan-Baldan L., Calvo F., Carvalho A.D., Felippotti T.T., de Oliveira R., Ubiali W.A., Paschoalin-Maurin T., Elias-Filho D.H., Motta V., da Silva L.A., and Coimbra N.C. Neuroanatomical and neuropharmacological study of opioid pathways in the mesencephalic tectum: effect of mu(1)- and kappa-opioid receptor blockade on escape behavior induced by electrical stimulation of the inferior colliculus. Brain Res. 5 (2003) 179-192
66. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (2005), Academic Press, Sydney
67. Pellow S., Chopin P., File S.E., and Briley M. Validation of open: closed arm entries in the elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14 (1985) 149-167
68. Risbrough V.B., and Stein M.B. Role of corticotropin-releasing factor in anxiety disorders: a translational research perspective. Horm. Behav. 50 (2006) 550-561
69. Risold P.Y., and Swanson L.W. Connections of the rat lateral septal complex. Brain Res. Rev. 24 (1997) 115-195
70. Rivier C.L., Grigoriadis D.E., and Rivier J.E. Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors. Endocrinology 144 (2003) 2396-2403
71. Rodgers R.J., and Johnson N.J. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol. Biochem. Behav. 52 (1995) 297-303
72. Rodgers R.J., Haller J., Holmes A., Halasz J., Walton T.J., and Brain P.F. Corticosterone response to the plus-maze: high correlation with risk assessment in rats and mice. Physiol. Behav. 68 (1999) 47-53
73. Schenberg L.C., Povoa R.M., Costa A.L., Caldellas A.V., Tufik S., and Bittencourt A.S. Functional specializations within the tectum defense systems of the rat. Neurosci. Biobehav. Rev. 29 (2005) 1279-1298
74. Swanson L.W., Sawchenko P.E., Rivier J., and Vale W.W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36 (1983) 165-186
75. Vale W.W., Spiess J., Rivier C., and Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 18 (1981) 1394-1397
76. Vianna D.M., Borelli K.G., Ferreira-Netto C., Macedo C.E., and Brandão M.L. Fos-like immunoreactive neurons following electrical stimulation of the dorsal periaqueductal gray at freezing and escape thresholds. Brain Res. Bull. 30 (2003) 179-189
77. Yang M., Farrokhi C., Vasconcellos A., Blanchard R.J., and Blanchard D.C. Central infusion of ovine CRF (oCRF) potentiates defensive behaviors in CD-1 mice in the Mouse Defense Test Battery (MDTB). Behav. Brain Res. 171 (2006) 1-8
78. Zanoveli, J.M., Ferreira-Netto, C., Brandão, M.L., 2007. Conditioned place aversion organized in the dorsal periaqueductal gray recruits the laterodorsal nucleus of thalamus and basolateral amygdala. doi:10.1016/j.expneurol.2007.08.007.
79. Zienowicz M., Wislowska-Stanek A., Lehner M., Taracha E., Skorzewska A., Bidzinski A., Turzynska D., Sobolewska A., Walkowiak J., Maciejak P., Szyndler J., and Plaznik A. Fluoxetine attenuates the effects of pentylenetetrazol on rat freezing behavior and c-Fos expression in the dorsomedial periaqueductal gray. Neurosci. Lett. 13 (2007) 252-256