Quantitative backscattered electron imaging of bone in proximal femur fragility fracture and medical illness

Journal of Microscopy

Volumn 229, Issue 1, 2008, Pages 60-66

  Sutton Smith, P ^a,b   Beard, H ^a   Fazzalari, N ^a,b  

^a HANSON INSTITUTE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Age related change; Bone mineralization; Chronic illness; Osteoporosis

Indexed keywords

ARTHROPLASTY; BACKSCATTERING; CALCIUM; DISEASES; FRACTURE; MEDICAL IMAGING; SCANNING ELECTRON MICROSCOPY;

AGE-RELATED CHANGES; BACKSCATTERED ELECTRON IMAGING; BONE MINERALIZATION; BONE QUALITY; CHRONIC ILLNESS; FRACTURE GROUP; MEDICAL CONDITIONS; MINERALISATION; OSTEOPOROSIS; PROXIMAL FEMUR;

BONE;

METHACRYLIC ACID METHYL ESTER;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BONE BIOPSY; BONE MATRIX; BONE MINERALIZATION; BONE TURNOVER; FEMALE; FEMUR FRACTURE; FRAGILITY FRACTURE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPE; SCANNING ELECTRON MICROSCOPY; TOTAL HIP PROSTHESIS; TRABECULAR BONE;

EID: 37349074523     PISSN: 00222720     EISSN: 13652818     Source Type: Journal    
DOI: 10.1111/j.1365-2818.2007.01867.x     Document Type: Article

References (36)

1. Bagi, C.M., Hanson, N., Andresen, C., Pero, R., Lariviere, R., Turner, C.H. & Laib, A. (2006) The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA. Bone 38, 136 144.
2. Boivin, G. & Meunier, P.J. (2002) The degree of mineralization of bone tissue measured by computerized quantitative contact radiography. Calcif. Tissue. Int. 70, 503 511.
3. Boivin, G.Y., Chavassieux, P.M., Santora, A.C., Yates, J. & Meunier, P.J. (2000) Alendronate increases bone strength by increasing the mean degree of mineralisation of bone tissue in osteoporotic women. Bone 27, 687 694.
4. Boyce, T.M. & Bloebaum, R.D. (1993) Cortical aging differences and fracture implications for the human femoral neck. Bone 14, 769 778.
5. Boyde, A., Compston, J.E., Reeve, J., Bell, K.L., Noble, B.S., Jones, S.J. & Loveridge, N. (1998) Effect of estrogen suppression on the mineralization density of iliac crest biopsies in young women as assessed by backscattered electron imaging. Bone 22, 241 250.
6. Boyde, A., S.J J, Aerssens, J. & Dequecker, J. (1995) Mineral density quantitation of the human cortical iliac crest by backscattered electron image analysis: variations with age, sex, and degree of osteoarthritis. Bone 16, 619 627.
7. Currey, J. (2002) The adaption of mechanical properties to different functions. Structure and mechanics (ed. by Currey J. Bones pp. 124 145. Princeton University Press, Princeton and Oxford.
8. Daci, E., van Cromphaut, P. & Bouillon, R. (2002) Mechanisms influencing bone metabolism in chronic illness. Horm. Res. 58, 44 51.
9. Ebbesen, E.N., Thomsen, J.S., Beck-Nielsen, H., Nepper-Rasmussan, N.J. & Mosekilde, L. (1999) Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing. Bone 25, 713 724.
10. Felsenberg, D. & Boonen, S. (2005) The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin. Ther. 27, 1 11.
11. Follet, H., Boivin, G., Rumelhart, C. & Meunier, P.J. (2004) The degree of mineralisation is a determinant of bone strength: a study on human calcani. Bone 34, 783 789.
12. Grabner, B., Landis, W., Roschger, P., Rinnerthaler, S., Peterlik, H., Klaushofer, K. & Fratzl, P. (2001) Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim). Bone 29, 453 457.
13. Heaney, R.P. (2003) Is the paradigm shifting? Bone 33, 457 465.
14. Hui, S.L., Slemenda, C.W. & Johnston, C.C. (1988) Age and bone mass as predictors of fracture in a prospective study. J Clin. Invest. 81, 1804 1809.
15. Kingsmill, V.J. & Boyde, A. (1998) Mineralisation density of human mandibular bone: quantitative backscattered electron image analysis. J. Anat. 192, 245 256.
16. Li, B. & Aspden, R.M. (1997) Material properties of bone from the femoral neck and calcar femorale of patients with osteoporosis or osteoarthritis. Osteoporosis Int. 7, 450 456.
17. Loveridge, N., Power, J., Reeve, J. & Boyde, A. (2004) Bone mineralization density and femoral neck fragility. Bone 35, 929 941.
18. Misof, B.M., Roschger, P., Cosman, F., et al 2003) Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab 88, 1150 1156.
19. Mosekilde, L., Mosekilde, L. & Danielsen, C.C. (1987) Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals. Bone 8, 79 85.
20. Recker, R.R., Lappe, J., Davies, K.M. & Heaney, R.P. (2004) Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients. J. Bone Miner. Res. 19, 1628 1633.
21. Reid, S.A. & Boyde, A. (1987) Changes in the mineral density distribution in human bone with age: image analysis using backscattered electrons in the SEM. J. Bone. Miner Res 2, 13 22.
22. Robling, A., Castillo, A. & Turner, C. (2006) Biomechanical and molecular regulation of bone remodeling. Annu. Rev. Biomed. Eng. 8, 455 498.
23. Roschger, P., Grabner B.M., Rinnerthaler, S., Tesch, W., Kneissel, M., Berzlanovich, A., Klaushofer, K. & Fratzl, P. (2001a) Structural development of the mineralized tissue in the human L4 vertebral body. J. Struct. Biol. 136, 126 136.
24. Roschger, P., Fratzl, P., Eschberger, J. & Klaushofer, K. (1998) Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 24, 619 621.
25. Roschger, P., Fratzl, P., Eschberger, J. & Klaushofer, K. (1999) Letters to the editor. Bone 24, 620 621.
26. Roschger, P., Gupta, H.S., Berzlanovich, A., et al 2003) Constant mineralisation density distribution in cacellous human bone. Bone 32, 316 323.
27. Roschger, P., Rinnerthaler, S., Yates, J., Rodan, G.A., Fratzl, P. & Klaushofer, K. (2001b) Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29, 185 191.
28. Ruffoni, D., Fratzl, P., Roschger, P., Klaushofer, K. & Weinkamer, R. (2007) The bone mineralization density distribution as a fingerprint of the mineralization process. Bone 40, 1308 1319.
29. Shea, J.E., Vajda, E.G. & Bloebaum, R.D. (2001) Evidence of a hypermineralised calcified fibrocartilage on the human femoral neck and lesser trochanter. J. Anat. 198, 153 162.
30. Skedros, J.G., Bloebaum, R.D., Bachus, K.N. & Boyce, R.W. (1993) The meaning of graylevels in backscattered electron images of bone. J. Biomed. Mater. Res. 27, 47 56.
31. Sutton-Smith, P., Parkinson, I.H., Linn, A., Kooke, S. & Fazzalari, N.L. (2006) Trabecular rod buckling index in thoraco-lumbar vertebral bone. Clin. Anat. 19, 12 18.
32. Tsangari, H., Findlay, D.M. & Fazzalari, N.L. (2006) Structural and remodeling indices in the cancellous bone of the proximal femur across adulthood. Bone 40, 211 217.
33. Vajda, E.G. & Bloebaum, R.D. (1999) Age-related hypermineralization in the female proximal human femur. Anat. Rec. 255, 202 211.
34. Vajda, E.G., Skedros, J.G. & Bloebaum, R.D. (1995) Consistency in calibrated backscattered electron images of calcified tissues and minerals analysed in multiple imaging sessions. Scanning Microsc. 9, 741 755.
35. Vijayapalan, V., Sutton-Smith, P., Parkinson, I.H., Martin, R.B. & Fazzalari, N.L. (2003) Trabecular rod thickness by direct measurement from 3D SEM anaglyphs. Anat. Rec. Part A 271A, 286 290.
36. Xiang, A., Kanematsu, M., Kikkawa, H., Asano, S. & Kinoshita, M. (2006) Analysis of change of microcomputed tomography 3-dimensional bone parameters as a high-throughput tool to evaluate antisteoporotic effects of agents at an early stage of ovariectomy-induced osteoporosis in mice. Invest. Radiol. 41, 704 712.