Expression of OCT4 transcription factor in cutaneous neoplasia

Applied Immunohistochemistry and Molecular Morphology

Volumn 15, Issue 4, 2007, Pages 359-362

  Katona, Terrence M ^a   Billings, Steven D ^a   Montironi, Rodolfo ^b   Lopez Beltran, Antonio ^c   Cheng, Liang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Adnexal neoplasia; Basal cell carcinoma; Cutaneous neoplasia; Oct3 4; Stem cell marker

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4;

ARTICLE; BASAL CELL CARCINOMA; CHONDROID HIDRADENOMA; DERMAL DUCT TUMOR; FOLLICLE CYST; HIDRADENOMA; HIDRADENOMA PAPILLIFERUM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFUNDIBULO APOCRINE SEBACEOUS UNIT; MELANOCYTIC NEVUS; MERKEL CELL TUMOR; NEOPLASM; NEVI SEBACEI OF JADASSOHN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEBACEOUS CARCINOMA; SEBACEOUS CYST; SEBACEOUS GLAND ADENOMA; SEBACEOUS GLAND HYPERPLASIA; SKIN FUNCTION; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TRICHOBLASTOMA; TRICHOEPITHELIOMA; TUMOR; UTERINE ADNEXA TUMOR;

FEMALE; HUMANS; MALE; OCTAMER TRANSCRIPTION FACTOR-3; SKIN NEOPLASMS;

EID: 37349070682     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e31803006eb     Document Type: Article

References (23)

1. Cheng L, Thomas A, Roth LM, et al. OCT4: a novel biomarker for dysgerminoma of the ovary. Am J Surg Pathol. 2004;28:1341-1346.
2. de Jong J, Stoop H, Dohle GR, et al. Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours. J Pathol. 2005;206:242-249.
3. Hattab EM, Tu PH, Wilson JD, et al. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol. 2005;29:368-371.
4. Jones TD, Ulbright TM, Eble JN, et al. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol. 2004;28:935-940.
5. Looijenga LH, Stoop H, deLeeuw HP, et al. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res. 2003;63:2244-2250.
6. Jones TD, Ulbright TM, Eble JN, et al. OCT4: a sensitive and specific biomarker for intratubular germ cell neoplasia of the testis. Clin Cancer Res. 2004;10:8544-8547.
7. Jones TD, MacLennan GT, Bonnin JM, et al. Screening for intratubular germ cell neoplasia of the testis using OCT4 immunohistochemistry. Am J Surg Pathol. 2006;30:1427-1431.
8. Sung MT, MacLennan GT, Cheng L. Retroperitoneal seminoma in limited biopsies: morphologic criteria and immunonohistochemical findings in 30 cases. Am J Surg Pathol. 2006;30:766-773.
9. Cheng L, Sung MT, Cossu-Rocca P, et al. OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. J Pathol. 2007;211:1-9.
10. Sung MT, Jones TD, Beck BD, et al. OCT4 is superior to CD30 in the diagnosis of metastatic embryonal carcinomas after chemotherapy. Hum Pathol. 2006;37:662-667.
11. Okamoto K, Okazawa H, Okuda A. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990;60:461-472.
12. Scholer HR, Balling R, Hatzopoulos AK, et al. Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J. 1989;8:2551-2557.
13. Scholer HR, Dressler GR, Balling R, et al. Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 1990;9:2185-2195.
14. Tai MH, Chang CC, Olson LK, et al. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis. 2005;26:495-502.
15. Yu H, Fang D, Kumar S, et al. Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am J Pathol. 2006;168:1879-1888.
16. Bohle A, Studer UE, Sonntag RW, et al. Primary or secondary extragonadal germ cell tumors? J Urol. 1986;135:939-943.
17. Cheng L. Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry. Cancer. 2004;101:2006-2010.
18. Jones TD, Ulbright TM, Eble JN, et al. OCT4: a sensitive and specific biomarker for intratubular germ cell neoplasia of the testis. Clin Cancer Res. 2004;10:8544-8547.
19. Liu Y, Lyle S, Yang Z, et al. Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol. 2003;121:963-968.
20. Ma DR, Yang EN, Lee ST. A review: the location, molecular characterization and multipotency of hair follicle epidermal stem cells. Ann Acad Med Singapore. 2004;33:784-788.
21. Ohyama M, Terunuma A, Tock C, et al. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest. 2006;116:249-260.
22. Wicha M, Liu S, Dontu G. Cancer stem cells: an old idea-a paradigm shift. Cancer Res. 2006;66:1883-1890.
23. Pan CX, Zhu W, Cheng L. The implications of cancer stem cells in the treatment of cancer. Future Oncol. 2006;2:723-731.