Protection afforded against aerosol challenge by systemic immunisation with inactivated Francisella tularensis live vaccine strain (LVS)

Microbial Pathogenesis

Volumn 44, Issue 2, 2008, Pages 164-168

  Eyles, J E ^a   Hartley, M G ^a   Laws, T R ^a   Oyston, P C F ^a   Griffin, K F ^a   Titball, R W ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Adjuvant; Immunization; Mucosal; Pathogen; Tularemia; Virulence factors

Indexed keywords

ALUMINUM HYDROXIDE; CPG OLIGODEOXYNUCLEOTIDE; FRANCISELLA TULARENSIS LIVE VACCINE; IMMUNOGLOBULIN G1 ANTIBODY; ISCOM; LIVE VACCINE; UNCLASSIFIED DRUG;

AEROSOL; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG POTENCY; FEMALE; FRANCISELLA TULARENSIS; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; AEROSOLS; ALUMINUM HYDROXIDE; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; FEMALE; FRANCISELLA TULARENSIS; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; ISCOMS; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; SURVIVAL ANALYSIS; TULAREMIA; VACCINES, INACTIVATED;

FRANCISELLA TULARENSIS; MUS;

EID: 37349055344     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2007.08.009     Document Type: Article

References (25)

1. Salslaw S., Elgelsbach H., Wilson H., et al. Tularaemia vaccine study. I: Intracutaneous challenge. Arch Intern Med 107 (1961) 121-133
2. Tarnvik A., Ericsson M., Golovliov I., et al. Orchestration of the protective immune response to intracellular bacteria: Francisella tularensis as a model organism. FEMS Immunol Med Microbiol 13 3 (1996) 221-225
3. McCrumb F.R. Aerosol infection of man with Pasturella tularensis. Bacteriol Rev 25 (1961) 55-60
4. Olsufiev N.G., Emelyanova O.S., and Dunaeva T.N. Comparative studies of strains of B. tularense in the old and new world and their taxonomy. J Hyg Epidemiol Microbiol Immunol 3 (1959) 138-149
5. Anthony L.S.D., Ghadirian E., Nestel F.P., and Kongshavn P.A.L. The requirement for gamma interferon in resistance of mice to experimental tularemia. Microb Pathog 2 (1989) 3-14
6. Fortier A.H., Slayter M.V., Ziemba R., et al. Live vaccine strain of Francisella tularensis: infection and immunity in mice. Infect Immun 59 (1991) 2922-2928
7. Tarnvik A. Nature of protective immunity to Francisella tularensis. Rev Infect Dis 11 (1989) 440-451
8. Conlan J.W., Sjostedt A., and North R.J. Cd4(+) and Cd8(+) T-cell-dependent and T-cell-independent host-defense mechanisms can operate to control and resolve primary and secondary Francisella tularensis LVS infection in mice. Infect Immun 62 12 (1994) 5603-5607
9. Burke D.S. Immunization against tularaemia: analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory acquired infection. J Infect Dis 135 (1977) 55-60
10. Coriell L.L., King E.O., and Smith M.G. Studies on tularemia. IV. Observations on tularemia in control and vaccinated monkeys. J Immunol 58 (1948) 183-202
11. Kadull P.J., Reames H.R., Coriell L.L., and Foshay L. Studies on tularemia. V. Immunization of man. J Immunol 65 (1950) 425-435
12. Gordon M., Donaldson D.M., and Wright G.G. Immunization of mice with irradiated Pasteurellatularensis. J Immunol 114 (1964) 435-440
13. Eyles J.E., Unal B., Hartley M.G., et al. Immunodominant Francisella tularensis antigens identified using proteome microarray. Proteomics 7 13 (2007) 2172-2183
14. Elkins K.L., Rhinehart-Jones T.R., Stibitz S., et al. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol 162 4 (1999) 2291-2298
15. Fulop M., Mastroeni P., Green M., and Titball R.W. Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis. Vaccine 19 31 (2001) 4465-4472
16. Stenmark S., Lindgren H., Tarnvik A., and Sjostedt A. Specific antibodies contribute to the host protection against strains of Francisella tularensis subspecies holarctica. Microb Pathog 35 2 (2003) 73-80
17. Conlan J.W., Shen H., Webb A., and Perry M.B. Mice vaccinated with the O-antigen of Francisella tularensis LVS lipopolysaccharide conjugated to bovine serum albumin develop varying degrees of protective immunity against systemic or aerosol challenge with virulent type A and type B strains of the pathogen. Vaccine 20 29/30 (2002) 3465-3471
18. Conlan J.W., Vinogradov E., Monteiro M.A., and Perry M.B. Mice intradermally inoculated with the intact lipopolysaccharide, but not the lipid A or O-chain, from Francisella tularensis LVS rapidly acquire varying degrees of enhanced resistance against systemic or aerogenic challenge with virulent strains of the pathogen. Microb Pathog 34 1 (2003) 39-45
19. Chen W., Shen H., Webb A., et al. Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen: protection varies depending on pathogen virulence, route of exposure, and host genetic background. Vaccine 21 26 (2003) 3690-3700
20. Shen H., Chen W., and Conlan J.W. Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen. Vaccine 22 17/18 (2004) 2116-2121
21. Wu T.H., Hutt J.A., Garrison K.A., et al. Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A. Infect Immun 73 5 (2005) 2644-2654
22. Conlan J.W., Shen H., KuoLee R., et al. Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alpha beta T cell- and interferon gamma-dependent mechanism. Vaccine 23 19 (2005) 2477-2485
23. Williamson E.D., Eley S.M., Stagg A.J., et al. A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague. Vaccine 15 10 (1997) 1079-1084
24. Guyton A.C. Measurement of the respiratory volumes of laboratory animals. Am J Physiol 150 (1947) 70-77
25. Harper G.J., and Morton J.D. The respiratory retention of bacterial aerosols: experiments with radioactive spores. J Hyg 51 (1953) 372-385