Effect of the distal C162S mutation on the energetics of drug binding to p38α MAP kinase

Archives of Biochemistry and Biophysics

Volumn 469, Issue 2, 2008, Pages 232-242

  Todorova, Niya A ^a   Doseeva, Victoria ^a   Ramprakash, Jayanthi ^a   Schwarz, Frederick P ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

Differential scanning calorimetry; Drug p38 MAP kinase interactions; Isothermal titration calorimetry; Kinase isoforms

Indexed keywords

1 (2,6 DICHLOROPHENYL) 5 (2,4 DIFLUOROPHENYL) 7 PIPERIDIN 4 YL 3,4 DIHYDROQUINOLIN 2(1H) ONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; MITOGEN ACTIVATED PROTEIN KINASE 14; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BINDING; ENTHALPY; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; BIOCHEMISTRY; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; MAP KINASE SIGNALING SYSTEM; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE;

EID: 37349054113     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.10.014     Document Type: Article

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