A not-so-modest proposal that a "modest" increase in aldosterone causes hypertension and more

Hypertension

Volumn 51, Issue 1, 2008, Pages 39-40

  Pratt, J Howard ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSINOGEN;

3' UNTRANSLATED REGION; ALDOSTERONE RELEASE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; EDITORIAL; ESSENTIAL HYPERTENSION; GENE EXPRESSION; HIGH SODIUM INTAKE; HUMAN; HYPERTENSION; NONHUMAN; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ALDOSTERONE; ANIMALS; BLOOD PRESSURE; HUMANS; HYPERALDOSTERONISM; HYPERTENSION; MICE; RENIN; SODIUM;

EID: 37349049272     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.100024     Document Type: Editorial

References (10)

1. Calhoun DA. Is there an unrecognized epidemic of primary aldosteronism? Pro. Hypertension. 2007;50:447-453.
2. Kaplan NM. Is there an unrecognized epidemic of primary aldosteronism? Con. Hypertension. 2007;50:454-458.
3. Jeunemaitre X, Soubrier F, Kotelevtev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel J-M, Corvol P. Molecular basis of human hypertension: role of angiotensinogen. Cell. 1992;71:169-180.
4. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci. 1995;92:2735-2739.
5. Makhanova N, Hagaman J, Kim H-S, Smithies O. Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension. 2008;51:134-140.
6. Vasan RS, Evans JC, Larson MG, Wilson PW, Meigs JB, Rifai N, Benjamin EJ, Levy D. Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med. 2004;351:33-41.
7. El Gharbawy AH, Nadig VS, Kotchen JM, Grim CE, Sagar KB, Kaldunski M, Hamet P, Pausova Z, Gaudet D, Gossard F, Kotchen TA. Arterial pressure, left ventricular mass, and aldosterone in essential hypertension. Hypertension. 2001;37:845-850.
8. Rocha R, Stier CT Jr, Kifor I, Ochoa-Maya MR, Rennke HG, Williams GH, Adler GK. Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology. 2000;141:3871-3878.
9. Nishizaka MK, Zaman MA, Calhoun DA. Efficacy of low-dose spironolactone in subjects with resistant hypertension. Am J Hypertens. 2003;16:925-930.
10. Saha C, Eckert GJ, Ambrosius WT, Chun TY, Wagner MA, Zhao Q, Pratt JH. Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension. Hypertension. 2005;46:481-487.