Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: Identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility

Toxicology and Applied Pharmacology

Volumn 226, Issue 2, 2008, Pages 199-205

  Komissarova, Elena V ^a   Li, Ping ^a   Uddin, Ahmed N ^a   Chen, Xuyan ^a   Nadas, Arthur ^a   Rossman, Toby G ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arsenite; GGT1; Human; Lymphoblasts; Microarray; NFKBIE

Indexed keywords

ARSENIC TRIOXIDE; BIOLOGICAL MARKER; GAMMA GLUTAMYLTRANSFERASE; I KAPPA B; PROTEIN NFKBIE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOBLAST; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS;

ARSENITES; BIOLOGICAL MARKERS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-GLUTAMYLTRANSFERASE; GENE EXPRESSION; GLUTATHIONE; HUMANS; I-KAPPA B PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 37349035834     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.09.004     Document Type: Article

References (47)

1. Anderson M. Glutathione: an overview of biosynthesis and modulation. Chem.-Biol. Interact. 111-112 (1998) 1-14
2. Andrew A.S., Warren A.J., Barchowsky A., Temple K.A., Klei L., Soucy N.V., O'Hara K.A., and Hamilton J.W. Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ. Health Perspect. 111 (2003) 825-838
3. Argos M., Kibriya M.G., Parvez F., Jasmine F., Rakibuz-Zaman M., and Ahsan H. Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. Cancer Epidemiol. Biomark. Prev. 15 (2006) 1367-1375
4. Barchowsky A., Dudek E.J., Treadwell M.D., and Wetterhahn K.E. Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells. Free Radic. Biol. Med. 21 (1996) 783-790
5. Beinke S., and Ley S.C. Functions of NF-kB1 and NF-kB2 in immune cell biology. Biochem. J. 382 (2004) 393-409
6. Bolstad B.M., Irizarry R.A., Åstrand M., and Speed T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19 (2003) 185-193
7. Chowdhury U.K., Biswas B.K., Chowdhury T.R., Samanta G., Mandal B.K., Basu G.C., Chanda C.R., Lodh D., Saha K.C., Mukherjee S.K., Roy S., Kabir S., Quamruzzaman Q., and Chakraborti D. Groundwater arsenic contamination in Bangladesh and West Bengal, India (comment). Environ. Health Perspect. 108 (2000) 393-397
8. Delnomdediou M., Basti M.M., Otvos J.D., and Thomas D.J. Reduction and binding of arsenate and dimethylarsenate by glutathione: a multinuclear magnetic resonance study. Chem.-Biol. Interact. 90 (1994) 139-155
9. Dey S., Ouellette M., Lightbody J., Papadopoulou B., and Rosen B.P. An ATP-dependant As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 2192-2197
10. Ding M., Shi X., Castranova V., and Vallyathan V. Predisposing factors in occupational lung cancer: inorganic minerals and chromium. J. Environ. Pathol. Toxicol. Oncol. 19 (2000) 129-138
11. Emmerich F., Theurich S., Hummel M., Haeffker A., Vry M.S., Dohner K., Bommert K., Stein H., and Dorken B. Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. J. Pathol. 201 (2003) 413-420
12. Ghosh M., Shen J., and Rosen B.P. Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 5001-5006
13. Grossen P.E. Arsenic and SCE in human lymphocytes. Mutat. Res. 119 (1983) 415-419
14. Hanigan M.H. γ-Glutamyl transpeptidase, a glutathionase: its expression and function in carcinogenesis. Chem.-Biol. Interact. 111-112 (1998) 333-342
15. Hu Y., Jin X., and Snow E.T. Effect of arsenic on transcription factor AP-1 and NF-kB DNA binding activity and related gene expression. Toxicol. Lett. 133 (2002) 33-45
16. IARC (International agency for Research on Cancer). IARC monograph on the evaluation of carcinogenic risk of chemicals to human. Some metals and metallic compounds vol. 23 (1980), World Health Organization, Lyon, France
17. Kala S.V., Neely M.W., Kala G., Prater C.I., Atwood D.W., Rice J.S., and Lieberman M.W. The MRP/cMOAT transporter and As-glutathione complex formation are required for biliary excretion of As. J. Biol. Chem. 275 (2000) 33404-33408
18. Karin M., and Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin. Immunol. 12 (2000) 85-98
19. Karin M., and Lin A. NF-kB at the crossroads of life and death. Nat. Immunol. 3 (2002) 221-227
20. Karin M., Cao Y., Greten F.R., and Zhi-Wei L. NF-kB in cancer: from innocent bystander to major culprit. Nat. Rev., Cancer 2 (2002) 301-310
21. Karp D.R., Shimooku K., and Lipsky P.E. Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death. J. Biol. Chem. 276 (2001) 3798-3804
22. Komissarova E.V., Saha S.K., and Rossman T.G. Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol. Appl. Pharmacol. 202 (2005) 99-107
23. Lee T.C., Wei M.L., Chang W.J., Ho I.C., Lo J.F., Jan K.Y., and Huang H. Elevation of glutathione levels and glutathione S-transferase in arsenic-resistant Chinese hamster ovary cells. In Vitro Cell. Dev. Biol. 25 (1989) 442-448
24. Lee P.C., Ho I.C., and Lee T.C. Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. Toxicol. Sci. 85 (2005) 541-550
25. Leslie E.M., Haimeur A., and Waalkes M.P. As transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a triglutathione conjugate is required. J. Biol. Chem. 279 (2004) 32700-32708
26. Li M., Cai J.-F., and Chiu J.-F. Arsenic induces oxidative stress and activates stress gene expression in cultured lung epithelial cells. J. Cell. Biochem. 87 (2002) 29-38
27. Li P., Uddin A.N., Liu Z., Mukhopadhyay R., Komissarova E.V., Rosen B.P., and Rossman T.G. Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts. Mol. Cell. Biochem. 255 (2004) 79-85
28. Liao W.-T., Chang K.-L., Yu Ch.-L., Chen G.-Sh., Chang L.W., and Yu H.-S. Arsenic induces human keratinocyte apoptosis by the FAS/FAS ligand pathway, which correlates with alterations in nuclear factor-kappa B and activator protein-1 activity. J. Invest. Dermatol. 122 (2004) 125-129
29. McIntyre T.M., and Curthoys N.P. Renal catabolism of glutathione: characterization of a particulate rat renal dipeptidase that catalyzes the hydrolysis of cysteinylglycine. J. Biol. Chem. 257 (1982) 11915-11921
30. McIntyre T.M., and Curthoys N.P. Comparison of the hydrolytic and transfer activities of rat renal γ-glutamyltranspeptidase. J. Biol. Chem. 254 (1979) 6499-6504
31. Meister A., Tate S.S., and Greffith O.W. γ-Glutamyltranspeptidase. Methods Enzymol. 77 (1981) 237-253
32. NRC (National Research Council). Arsenic in Drinking Water (2000), National Academy Press, Washington, DC
33. Rajpert-De Meyts E., Shi M., Chang M., Robinson T.W., Groffen J., Heisterkamp N., and Forman H.J. Transfection with γ-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione. Toxicol. Appl. Pharmacol. 114 (1992) 56-62
34. Rayet B., and Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18 (1999) 6938-6947
35. Rea M.A., Gregg J.P., Qin Q., Phillips M.A., and Rice R.H. Global alteration of gene expression in human keratinocytes by inorganic arsenic. Carcinogenesis 24 (2003) 747-756
36. Rossman T.G., Uddin A.N., Burns F.J., and Bosland M.C. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol. Appl. Pharmacol. 176 (2001) 64-71
37. Scott N., Hatidlid K.M., and MacKensie N.E. Reaction of As(III) and As(V) species with glutathione. Chem. Res. Toxicol. 6 (1993) 102-106
38. Steinmaus C., Bates M., Yuan Y., Kalman D., Atallah R., Omar A., Biggs M., Hopenhayn C., Moore L., Hoang B., and Smith A. Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States. J. Occup. Environ. Med. 48 (2006) 478-488
39. Su P.F., Hu Y.J., Ho I.C., Cheng Y.M., and Lee T.C. Distinct gene expression profiles in immortalized human urothelial cells exposed to inorganic arsenite and its metabolites. Environ. Health Perspect. 114 (2006) 394-403
40. Tinwell H., Stephens S.C., and Ashby J. Arsenite as the probable active species in the human carcinogenicity of arsenic: mouse micronucleus assay on Na and K arsenite, orpiment, and Fowler's solution. Environ. Health Perspect. 95 (1991) 205-210
41. Uddin A.N., Burns F.J., and Rossman T.G. Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UV in mouse skin. Carcinogenesis 26 (2005) 2179-2186
42. Vega L., Gonsebatt M.E., and Ostrosky-Wegman P. Aneugenic effect of sodium arsenite on human lymphocytes in vitro: an individual susceptibility effect detected. Mutat. Res. 334 (1995) 365-373
43. Vernhet L., Allain N., Payen L., Anger J.P., Guillouzo A., and Fardel O. Resistance of human multidrug resistance-associated protein 1-expressing lung tumor cells to the anticancer drug As trioxide. Biochem. Pharmacol. 61 (2001) 1387-1391
44. Virag L., and Szabo C. The therapeutic potential of poly(ADP-Ribose) polymerase inhibitors. Pharmacol. Rev. 54 (2002) 375-429
45. Wang H.F., and Lee T.C. Glutathione S-transferase pi facilitates the excretion from As-resistant Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 192 (1993) 1093-1099
46. Wiencke J.K., and Yager J.W. Specificity of arsenite in potentiating cytogenetic damage induced by the DNA crosslinking agent diepoxybutane. Environ. Mol. Mutagen. 19 (1992) 195-200
47. Yih L.H., Peck K., and Lee T.C. Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment. Carcinogenesis 23 (2002) 867-876