The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China

Asia Pacific Journal of Clinical Nutrition

Volumn 16, Issue 4, 2007, Pages 598-601

  Sun, Hai Ming ^a   Qiao, Yuan Dong ^a   Chen, Feng ^a   Xu, Li Dan ^a   Bai, Jing ^a   Fu, Song Bin ^a,b,c  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Bio pharmaceutical Key Laboratory of Heilongjiang Province   (China)

^c NONE   (China)

Author keywords

China; Lactase; Lactose intolerance; Polymorphism; Population; Single nucleotide

Indexed keywords

LACTASE;

ARTICLE; CHINA; GENE AMPLIFICATION; GENE FREQUENCY; GENETICS; GENOTYPE; HUMAN; LACTOSE INTOLERANCE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; POPULATION GENETICS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

BASE SEQUENCE; CHINA; GENE AMPLIFICATION; GENE FREQUENCY; GENETICS, POPULATION; GENOTYPE; HUMANS; LACTASE; LACTOSE INTOLERANCE; MOLECULAR SEQUENCE DATA; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 37349034520     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Kretchmer, Norman. Lactose intolerance and malabsorption. In: Kenneth F. Kiple, eds. The Cambridge world history of human disease. Cambridge and New York, 1993;813-817.
2. Swallow DM, Hollox EJ. The genetic polymorphism of intestinal lactase activity in adult humans. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic and molecular basis of inherited disease. McGraw-Hill, New York, 2000.
3. Troelsen JT. Adult-type hypolactasia and regulation of lactase expression. Biochim Biophys Acta. 2005;1723:19-32.
4. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I. Identification of a variant associated with adult-type hypolactasia. Nat Genet. 2002;30:233-237.
5. Olds LC, Sibley E. Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum Mol Genet. 2003;12:2333-2340.
6. Lewinsky RH, Jensen TG, Moller J, Stensballe A, Olsen J, Troelsen JT. T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. Hum Mol Genet. 2005;14:3945-3953.
7. Rasinpera H, Savilahti E, Enattah NS, Kuokkanen M, Totterman N, Lindahl H, Jarvela I, Kolho KL. A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut. 2004;53:1571-1576.
8. Hogenauer C, Hammer HF, Mellitzer K, Renner W, Krejs GJ, Toplak H. Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol. 2005;17:371-376.
9. Bodlaj G, Stocher M, Hufnagl P, Hubmann R, Biesenbach G, Stekel H, Berg J. Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance. Clin Chem. 2006;52:148-151.
10. Mulcare CA, Weale ME, Jones AL, Connell B, Zeitlyn D, Tarekegn A, Swallow DM, Bradman N, Thomas MG. The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans. Am J Hum Genet. 2004;74:1102-1110.
11. Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN. Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet. 2004;74:1111-1120.
12. Wang YG, Yan YS, Xu JJ, Du RF, Flatz SD, Kuhnau W, Flatz G. Prevalence of primary adult lactose malabsorption in three populations of northern China. Hum Genet. 1984;67:103-106.
13. Poulter M, Hollox E, Harvey CB, Mulcare C, Peuhkuri K, Kajander K, Sarner M, Korpela R, Swallow DM. The causal element for the lactase persistence/non-persistence polymorphism is located in a 1 Mb region of linkage disequilibrium in Europeans. Ann Hum Genet. 2003;67:298-311.
14. Du, RF, Ye FS. Chinese Nationalities. Beijing: Science Publishing House, 1994.