Tonic-clonic seizure as the presentation symptom of severe hypocalcemia secondary to zoledronic acid administration [1]

Journal of Palliative Medicine

Volumn 10, Issue 6, 2007, Pages 1226-1227

  Navarro, Miguel ^a   López, Rafael ^a   Alaña, Monica ^a   Ocaña, Alberto ^a   Leno, Ruben ^a   Sánchez, Feliciano ^a   Fonseca, Emilio ^a   Cruz, Juan J ^a  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM GLUBIONATE; ZOLEDRONIC ACID;

AGED; BONE METASTASIS; BONE PAIN; CALCIUM BLOOD LEVEL; CANCER PAIN; CANCER PALLIATIVE THERAPY; CASE REPORT; CLINICAL FEATURE; DISEASE SEVERITY; DRUG SAFETY; HUMAN; HYPOCALCEMIA; LETTER; MALE; PROSTATE CANCER; TONIC CLONIC SEIZURE;

AGED, 80 AND OVER; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; EPILEPSY, TONIC-CLONIC; HUMANS; HYPOCALCEMIA; IMIDAZOLES; MALE; SEVERITY OF ILLNESS INDEX; SPAIN;

EID: 37349025459     PISSN: 10966218     EISSN: None     Source Type: Journal    
DOI: 10.1089/jpm.2007.0113     Document Type: Letter

References (6)

1. Wellington K, Goa KL: Zoledronic acid: A review of its use in the management of bone metastasis and hypercalcaemia of malignancy. Drugs 2003;63:417-437.
2. Saad F, Gleason DM, Murray R, Tchekmedyian S, Venner P, Lacombe L, Chin JL, Vinholes JJ, Goas JA, Chen B; Zoledronic Acid Prostate Cancer Study Group: A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 2002;94:1458-1468.
3. Breen TL, Shane E: Prolonged hypocalcemia after treatment with zoledronic acid in a patient with prostate cancer and vitamin D deficiency. J Clin Oncol 2004;22:1531-1532.
4. Tassinari D, Poggi B, Nicoletti S, Fantini M, Tamburini E, Possenti C, Sartori S: Zoledronic acid treatment at home: Safety data from an observational prospective trial. J Palliat Med 2007;10:352-356.
5. Peter R, Mishra V, Fraser WD: Severe hypocalcemia after being given intravenous bisphosphonate. BMJ 2004;328:335-336.
6. Rosen CJ, Brown S: Severe hypocalcemia after intravenous bisphosphonate therapy in occult vitamin D deficiency. N Engl J Med 2003;348:1503-1504.