메뉴 건너뛰기




Volumn 120, Issue 7, 2007, Pages 1796-1807

Self-inducing shape memory geometric cues embedded within smart hydroxyapatite-based biomimetic matrices

Author keywords

[No Author keywords available]

Indexed keywords

BIOCERAMICS; CALCIUM PHOSPHATE; CARBON; HYDROXYAPATITE; MESSENGER RNA; OSTEOGENIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA;

EID: 37349022129     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000287133.43718.89     Document Type: Article
Times cited : (42)

References (49)
  • 1
    • 0026049321 scopus 로고
    • Tissue transformation into bone in vivo
    • Khouri, R. K., Koudsi, B., and Reddi, A. H. Tissue transformation into bone in vivo. J.A.M.A. 266: 1953, 1991.
    • (1991) J.A.M.A , vol.266 , pp. 1953
    • Khouri, R.K.1    Koudsi, B.2    Reddi, A.H.3
  • 2
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer, R., and Vacanti, J. P. Tissue engineering. Science 260: 930, 1993.
    • (1993) Science , vol.260 , pp. 930
    • Langer, R.1    Vacanti, J.P.2
  • 3
    • 0026453628 scopus 로고
    • Regulation of cartilage and bone differentiation by bone morphogenetic proteins
    • Reddi, A. H. Regulation of cartilage and bone differentiation by bone morphogenetic proteins. Curr. Opin. Cell Biol. 4: 850, 1992.
    • (1992) Curr. Opin. Cell Biol , vol.4 , pp. 850
    • Reddi, A.H.1
  • 4
    • 0029007273 scopus 로고
    • Biomaterials in tissue engineering
    • Hubbell, J. A. Biomaterials in tissue engineering. Biotechnology 13: 565, 1995.
    • (1995) Biotechnology , vol.13 , pp. 565
    • Hubbell, J.A.1
  • 5
    • 0033843085 scopus 로고    scopus 로고
    • Morphogenesis and tissue engineering of bone and cartilage: Inductive signals, stem cells, and biomimetic biomaterials
    • Reddi, A. H. Morphogenesis and tissue engineering of bone and cartilage: Inductive signals, stem cells, and biomimetic biomaterials. Tissue Eng. 6: 351, 2000.
    • (2000) Tissue Eng , vol.6 , pp. 351
    • Reddi, A.H.1
  • 6
    • 21344468549 scopus 로고    scopus 로고
    • Osteogenic proteins of the TGF-β superfamily
    • H. L. Henry and A. W. Norman Eds, Austin: Academic Press, Pp
    • Ripamonti, U. Osteogenic proteins of the TGF-β superfamily. In H. L. Henry and A. W. Norman (Eds.), Encyclopedia of Hormones. Austin: Academic Press, 2003. Pp. 80-86.
    • (2003) Encyclopedia of Hormones , pp. 80-86
    • Ripamonti, U.1
  • 7
    • 16544361804 scopus 로고    scopus 로고
    • Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues
    • Ripamonti, U. Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues. J. Cell. Mol. Med. 8: 169, 2004.
    • (2004) J. Cell. Mol. Med , vol.8 , pp. 169
    • Ripamonti, U.1
  • 8
    • 21344441394 scopus 로고    scopus 로고
    • Molecular signals in geometrical cues sculpt bone morphology
    • Ripamonti, U. Molecular signals in geometrical cues sculpt bone morphology. S. Afr. J. Sci. 100: 355, 2004.
    • (2004) S. Afr. J. Sci , vol.100 , pp. 355
    • Ripamonti, U.1
  • 9
    • 21344468315 scopus 로고    scopus 로고
    • Soluble signals and insoluble substrata: Novel molecular cues instructing the induction of bone
    • E. J. Massaro and J. M. Rogers Eds, Totowa, N.J, Humana Press, Pp
    • Ripamonti, U., Ramoshebi, L. N., Patton, J., et al. Soluble signals and insoluble substrata: Novel molecular cues instructing the induction of bone. In E. J. Massaro and J. M. Rogers (Eds.), The Skeleton. Totowa, N.J.: Humana Press, 2004. Pp. 217-227.
    • (2004) The Skeleton , pp. 217-227
    • Ripamonti, U.1    Ramoshebi, L.N.2    Patton, J.3
  • 10
    • 21344434496 scopus 로고    scopus 로고
    • Sculpting the architecture of mineralized tissue: Tissue engineering of bone from soluble signals to smart biomimetic matrices
    • R. H. Muller and O. Kayser Eds, Berlin: Wiley-VCH, Pp
    • Ripamonti, U., Ramoshebi, L. N., Patton, J., et al. Sculpting the architecture of mineralized tissue: Tissue engineering of bone from soluble signals to smart biomimetic matrices. In R. H. Muller and O. Kayser (Eds.), Pharmaceutical Biotechnology. Berlin: Wiley-VCH, 2004, Pp. 281-297.
    • (2004) Pharmaceutical Biotechnology , pp. 281-297
    • Ripamonti, U.1    Ramoshebi, L.N.2    Patton, J.3
  • 11
    • 21344453815 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: Experimental studies in the non-human primate Papio ursinus
    • Ripamonti, U., Herbst, N. N., and Ramoshebi, L. N. Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: Experimental studies in the non-human primate Papio ursinus. Cytokine Growth Factor Rev. 16: 357, 2005.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 357
    • Ripamonti, U.1    Herbst, N.N.2    Ramoshebi, L.N.3
  • 12
    • 26944486872 scopus 로고    scopus 로고
    • Soluble osteogenic molecular signals and the induction of bone formation
    • Ripamonti, U. Soluble osteogenic molecular signals and the induction of bone formation. Biomaterials 27: 807, 2006.
    • (2006) Biomaterials , vol.27 , pp. 807
    • Ripamonti, U.1
  • 13
    • 26944460663 scopus 로고    scopus 로고
    • Intrinsic osteoinductivity of smart biomaterials with inductive and morphogenetic shape memory geometries. Abstract
    • presented at the, I-ASMU, Montreal, Quebec, Canada
    • Ripamonti, U., and Crooks, J. Intrinsic osteoinductivity of smart biomaterials with inductive and morphogenetic shape memory geometries. Abstract presented at the 7th International Academy of Shape Memory Material for Medical Use (I-ASMU), Montreal, Quebec, Canada, 2000.
    • (2000) 7th International Academy of Shape Memory Material for Medical Use
    • Ripamonti, U.1    Crooks, J.2
  • 14
    • 0032862824 scopus 로고    scopus 로고
    • Sintered porous hydroxyapatites with intrinsic osteoinductive activity: Geometric induction of bone formation
    • Ripamonti, U., Crooks, J., and Kirkbride, A. N. Sintered porous hydroxyapatites with intrinsic osteoinductive activity: Geometric induction of bone formation. S. Afr. J. Sci. 95: 335, 1999.
    • (1999) S. Afr. J. Sci , vol.95 , pp. 335
    • Ripamonti, U.1    Crooks, J.2    Kirkbride, A.N.3
  • 15
    • 0000978476 scopus 로고    scopus 로고
    • Smart biomaterials with intrinsic osteoinductivity: Geometric control of bone differentiation
    • F. J. E. Davis Ed, Toronto: EM2 Corporation, Pp
    • Ripamonti, U. Smart biomaterials with intrinsic osteoinductivity: Geometric control of bone differentiation. In F. J. E. Davis (Ed.), Bone Engineering. Toronto: EM2 Corporation, 2000. Pp. 25-222.
    • (2000) Bone Engineering , pp. 25-222
    • Ripamonti, U.1
  • 16
    • 0035043853 scopus 로고    scopus 로고
    • Bone induction by BMPs/OPs and related family members in primates: The critical role of delivery systems
    • Ripamonti, U., Ramoshebi, L. N., Matsaba, T., et al. Bone induction by BMPs/OPs and related family members in primates: The critical role of delivery systems. J. Bone Joint Surg. (Am.) 83: 16, 2001.
    • (2001) J. Bone Joint Surg. (Am.) , vol.83 , pp. 16
    • Ripamonti, U.1    Ramoshebi, L.N.2    Matsaba, T.3
  • 17
    • 21344472730 scopus 로고    scopus 로고
    • Tissue engineering of bone by novel substrata instructing gene expression during the de novo bone formation
    • March, Available at
    • Ripamonti, U. Tissue engineering of bone by novel substrata instructing gene expression during the de novo bone formation. Science in Africa March 2002. Available at: http:// www.scienceinafrica.co.za/2002/march/bone2. htm.
    • (2002) Science in Africa
    • Ripamonti, U.1
  • 18
    • 0027312330 scopus 로고
    • Histomorphometry of iliac crest trabecular bone in adult male baboons in captivity
    • Schnitzler, C. M., Ripamonti, U., and Mesquita, M. Histomorphometry of iliac crest trabecular bone in adult male baboons in captivity. Calcif. Tissue Int. 52: 447, 1993.
    • (1993) Calcif. Tissue Int , vol.52 , pp. 447
    • Schnitzler, C.M.1    Ripamonti, U.2    Mesquita, M.3
  • 19
    • 21344465113 scopus 로고
    • Primate model: Evaluation of bone substitutes in craniofacial reconstruction
    • M. B. Habal and A. H. Reddi Eds, Philadelphia: Saunders, Pp
    • Ripamonti, U. Primate model: Evaluation of bone substitutes in craniofacial reconstruction. In M. B. Habal and A. H. Reddi (Eds.), Bone Grafts & Bone Substitutes. Philadelphia: Saunders, 1992. Pp. 235-240.
    • (1992) Bone Grafts & Bone Substitutes , pp. 235-240
    • Ripamonti, U.1
  • 20
    • 0003060851 scopus 로고    scopus 로고
    • The generation of bone in primates by bone morphogenetic proteins
    • T. S. Lindholm Ed, Georgetown, Texas: R. G. Landes Company, Pp
    • Ripamonti, U. The generation of bone in primates by bone morphogenetic proteins. In T. S. Lindholm (Ed.), Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery. Georgetown, Texas: R. G. Landes Company, 1996. Pp. 131-145.
    • (1996) Bone Morphogenetic Proteins: Biology, Biochemistry and Reconstructive Surgery , pp. 131-145
    • Ripamonti, U.1
  • 22
    • 84937360496 scopus 로고
    • Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons
    • Ripamonti, U., Ma, S. S., and Reddi, A. H. Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons. Plast. Reconstr. Surg. 89: 731, 1992.
    • (1992) Plast. Reconstr. Surg , vol.89 , pp. 731
    • Ripamonti, U.1    Ma, S.S.2    Reddi, A.H.3
  • 23
    • 0027332277 scopus 로고
    • Expression of the osteogenic phenotype in porous hydroxyapatite implanted extraskeletally in baboons
    • Ripamonti, U., van den Heever, B., and van Wyk, J. Expression of the osteogenic phenotype in porous hydroxyapatite implanted extraskeletally in baboons. Matrix 13: 491, 1993.
    • (1993) Matrix , vol.13 , pp. 491
    • Ripamonti, U.1    van den Heever, B.2    van Wyk, J.3
  • 24
    • 0028220402 scopus 로고
    • Bone differentiation in porous hydroxyapatite in baboons is regulated by the geometry of the substratum: Implications for reconstructive craniofacial surgery
    • van Eeden, S. P., and Ripamonti, U. Bone differentiation in porous hydroxyapatite in baboons is regulated by the geometry of the substratum: Implications for reconstructive craniofacial surgery. Plast. Reconstr. Surg. 93: 959, 1994.
    • (1994) Plast. Reconstr. Surg , vol.93 , pp. 959
    • van Eeden, S.P.1    Ripamonti, U.2
  • 25
    • 0029655796 scopus 로고    scopus 로고
    • Osteoinduction in porous hydroxyapatite implanted in heterotopic sites of different animal models
    • Ripamonti, U. Osteoinduction in porous hydroxyapatite implanted in heterotopic sites of different animal models. Biomaterials 17: 31, 1996.
    • (1996) Biomaterials , vol.17 , pp. 31
    • Ripamonti, U.1
  • 26
    • 0026952990 scopus 로고
    • Calvarial reconstruction in baboons with porous hydroxyapatite
    • Ripamonti, U. Calvarial reconstruction in baboons with porous hydroxyapatite. J. Craniofac. Surg. 3: 149, 1992.
    • (1992) J. Craniofac. Surg , vol.3 , pp. 149
    • Ripamonti, U.1
  • 27
    • 0026794464 scopus 로고
    • Osteogenin, a bone morphogenetic protein, absorbed on porous hydroxyapatite substrata, induces rapid bone differentiation in calvarial defects of adult primates
    • Ripamonti, U., Ma, S., van den Heever, B., and Reddi, A. H. Osteogenin, a bone morphogenetic protein, absorbed on porous hydroxyapatite substrata, induces rapid bone differentiation in calvarial defects of adult primates. Plast. Reconstr. Surg. 90: 382, 1992.
    • (1992) Plast. Reconstr. Surg , vol.90 , pp. 382
    • Ripamonti, U.1    Ma, S.2    van den Heever, B.3    Reddi, A.H.4
  • 28
    • 0035313214 scopus 로고    scopus 로고
    • Induction of bone formation by recombinant human osteogenic protein-1 and sintered porous hydroxyapatite in adult primates
    • Ripamonti, U., Crooks, J., and Rueger, D. C. Induction of bone formation by recombinant human osteogenic protein-1 and sintered porous hydroxyapatite in adult primates. Plast. Reconstr. Surg. 107: 977, 2001.
    • (2001) Plast. Reconstr. Surg , vol.107 , pp. 977
    • Ripamonti, U.1    Crooks, J.2    Rueger, D.C.3
  • 29
    • 0033848938 scopus 로고    scopus 로고
    • Long-term evaluation of bone formation by osteogenic protein-1 in the baboon and relative efficacy of bone-derived bone morphogenetic proteins delivered by irradiated xenogeneic collagenous matrices
    • Ripamonti, U., van den Heever, B., Crooks, J., Rueger, D. C., and Reddi, A. H. Long-term evaluation of bone formation by osteogenic protein-1 in the baboon and relative efficacy of bone-derived bone morphogenetic proteins delivered by irradiated xenogeneic collagenous matrices. J. Bone Miner. Res. 15: 798, 2000.
    • (2000) J. Bone Miner. Res , vol.15 , pp. 798
    • Ripamonti, U.1    van den Heever, B.2    Crooks, J.3    Rueger, D.C.4    Reddi, A.H.5
  • 30
    • 0030766087 scopus 로고    scopus 로고
    • Recombinant transforming growth factor-β1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation
    • Ripamonti, U., Duneas, N., van den Heever, B., Bosch, C., and Crooks, J. Recombinant transforming growth factor-β1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation. J. Bone Miner. Res. 12: 1584, 1997.
    • (1997) J. Bone Miner. Res , vol.12 , pp. 1584
    • Ripamonti, U.1    Duneas, N.2    van den Heever, B.3    Bosch, C.4    Crooks, J.5
  • 31
    • 0034005590 scopus 로고    scopus 로고
    • Induction of endochondral bone formation by recombinant human transforming growth factor-β2 in the baboon (Papio ursinus)
    • Ripamonti, U., Crooks, J., Matsaba, T., and Tasker, J. Induction of endochondral bone formation by recombinant human transforming growth factor-β2 in the baboon (Papio ursinus). Growth Factors 17: 269, 2000.
    • (2000) Growth Factors , vol.17 , pp. 269
    • Ripamonti, U.1    Crooks, J.2    Matsaba, T.3    Tasker, J.4
  • 32
    • 30944433188 scopus 로고    scopus 로고
    • Bone induction by recombinant human osteogenic protein-1 (hOP-1, BMP-7) in the primate Papio ursinus with expression of mRNA of gene products of the TGF-β superfamily
    • Ripamonti, U. Bone induction by recombinant human osteogenic protein-1 (hOP-1, BMP-7) in the primate Papio ursinus with expression of mRNA of gene products of the TGF-β superfamily. J. Cell. Mol. Med. 9: 911, 2005.
    • (2005) J. Cell. Mol. Med , vol.9 , pp. 911
    • Ripamonti, U.1
  • 33
    • 0001817786 scopus 로고
    • Stereological basis of bone histomorphometry: Theory of quantitative microscopy and reconstruction of the third dimension
    • R. R. Recher Ed, Boca Raton, Fla, CRC Press, Pp
    • Parfitt, A. M. Stereological basis of bone histomorphometry: Theory of quantitative microscopy and reconstruction of the third dimension. In R. R. Recher (Ed.), Bone Histomorphometry: Techniques and Interpretation. Boca Raton, Fla.: CRC Press, 1993. Pp. 53-87.
    • (1993) Bone Histomorphometry: Techniques and Interpretation , pp. 53-87
    • Parfitt, A.M.1
  • 34
    • 0024232659 scopus 로고
    • The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1 (IV) chain
    • Hostikka, S. L., and Tryggvason, K. The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1 (IV) chain. J. Biol. Chem. 263: 19488, 1988.
    • (1988) J. Biol. Chem , vol.263 , pp. 19488
    • Hostikka, S.L.1    Tryggvason, K.2
  • 35
    • 0025362715 scopus 로고
    • OP-1 cDNA encodes an osteogenic protein in the TGF-β family
    • Özkaynak, E., Rueger, D. C., Drier, E. F., et al. OP-1 cDNA encodes an osteogenic protein in the TGF-β family. E.M.B.O. J. 9: 2085, 1990.
    • (1990) E.M.B.O. J , vol.9 , pp. 2085
    • Özkaynak, E.1    Rueger, D.C.2    Drier, E.F.3
  • 36
    • 0001162106 scopus 로고
    • Formation by autoinduction
    • Urist, M. R. Bone: Formation by autoinduction. Science 220: 680, 1965.
    • (1965) Science , vol.220 , pp. 680
    • Urist, M.R.B.1
  • 37
    • 0004503871 scopus 로고
    • Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation
    • Sampath, T. K., and Reddi, A. H. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc. Natl. Acad. Sci. U.S.A. 78: 7599, 1981.
    • (1981) Proc. Natl. Acad. Sci. U.S.A , vol.78 , pp. 7599
    • Sampath, T.K.1    Reddi, A.H.2
  • 38
    • 0002791734 scopus 로고
    • Bone morphogenetic proteins: Applications in plastic and reconstructive surgery
    • Ripamonti, U., and Reddi, A. H. Bone morphogenetic proteins: Applications in plastic and reconstructive surgery. Adv. Plast. Reconstr. Surg. 11: 47, 1995.
    • (1995) Adv. Plast. Reconstr. Surg , vol.11 , pp. 47
    • Ripamonti, U.1    Reddi, A.H.2
  • 39
    • 0031973396 scopus 로고    scopus 로고
    • Tissue morphogenesis and regeneration by bone morphogenetic proteins
    • Ripamonti, U., and Duneas, N. Tissue morphogenesis and regeneration by bone morphogenetic proteins. Plast. Reconstr. Surg. 101: 227, 1998.
    • (1998) Plast. Reconstr. Surg , vol.101 , pp. 227
    • Ripamonti, U.1    Duneas, N.2
  • 40
    • 0001459913 scopus 로고
    • The formation of bone under the influence of epithelium of the urinary tract
    • Huggins, C. B. The formation of bone under the influence of epithelium of the urinary tract. Arch. Surg. 22: 377, 1931.
    • (1931) Arch. Surg , vol.22 , pp. 377
    • Huggins, C.B.1
  • 41
    • 26944438228 scopus 로고
    • Sulla produzione eteroplastica dell'osso
    • Sacerdotti, C., and Frattin, G. Sulla produzione eteroplastica dell'osso. R. Accad. Med. Torino 36: 825, 1901.
    • (1901) R. Accad. Med. Torino , vol.36 , pp. 825
    • Sacerdotti, C.1    Frattin, G.2
  • 42
    • 0014664960 scopus 로고
    • Heterotopic bone formed in a synthetic sponge in the skin of young pigs
    • Winter, G. D., and Simpson, B. J. Heterotopic bone formed in a synthetic sponge in the skin of young pigs. Nature 223: 88, 1969.
    • (1969) Nature , vol.223 , pp. 88
    • Winter, G.D.1    Simpson, B.J.2
  • 43
    • 0025944038 scopus 로고
    • The morphogenesis of bone in replicas of porous hydroxyapatite obtained from conversion of calcium carbonate exoskeletons of coral
    • Ripamonti, U. The morphogenesis of bone in replicas of porous hydroxyapatite obtained from conversion of calcium carbonate exoskeletons of coral. J. Bone Joint Surg. (Am.) 73: 692, 1991.
    • (1991) J. Bone Joint Surg. (Am.) , vol.73 , pp. 692
    • Ripamonti, U.1
  • 45
    • 0030298198 scopus 로고    scopus 로고
    • Osteogenesis in extraskeletally implanted porous calcium phosphate ceramics: Variability among different kinds of animals
    • Yang, Z., Yuan, H., Tong, W., Zou, P., Chen, W., and Zhang, X. Osteogenesis in extraskeletally implanted porous calcium phosphate ceramics: Variability among different kinds of animals. Biomaterials 17: 2131, 1996.
    • (1996) Biomaterials , vol.17 , pp. 2131
    • Yang, Z.1    Yuan, H.2    Tong, W.3    Zou, P.4    Chen, W.5    Zhang, X.6
  • 46
    • 0036160839 scopus 로고    scopus 로고
    • A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: Part I
    • Gosain, A. K., Song, L., Riordan, P., et al. A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: Part I. Plast. Reconstr. Surg. 109: 619, 2002.
    • (2002) Plast. Reconstr. Surg , vol.109 , pp. 619
    • Gosain, A.K.1    Song, L.2    Riordan, P.3
  • 47
    • 14944341184 scopus 로고    scopus 로고
    • A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: Part II. Bioengineering implants to optimize bone replacement in reconstruction of cranial defects
    • Gosain, A. K., Riordan, P., Song, L., et al. A 1-year study of osteoinduction in hydroxyapatite-derived biomaterials in an adult sheep model: Part II. Bioengineering implants to optimize bone replacement in reconstruction of cranial defects. Plast. Reconstr. Surg. 114: 1155, 2004.
    • (2004) Plast. Reconstr. Surg , vol.114 , pp. 1155
    • Gosain, A.K.1    Riordan, P.2    Song, L.3
  • 48
    • 23844500338 scopus 로고    scopus 로고
    • Mechanical control of tissue growth: Function follows form
    • Ingber, D. E. Mechanical control of tissue growth: Function follows form. Proc. Natl. Acad. Sci. U.S.A. 102: 11571, 2005.
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 11571
    • Ingber, D.E.1
  • 49
    • 23844487086 scopus 로고    scopus 로고
    • Emergent patterns of growth controlled in multicellular form and mechanics
    • Nelson, C. M., Jean, R. P., Tan, J. L., et al. Emergent patterns of growth controlled in multicellular form and mechanics. Proc. Natl. Acad. Sci. U.S.A. 102: 11594, 2005.
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 11594
    • Nelson, C.M.1    Jean, R.P.2    Tan, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.