Doxycycline clearance of experimentally induced chronic Ehrlichia canis infection in dogs

Journal of Veterinary Internal Medicine

Volumn 21, Issue 6, 2007, Pages 1237-1242

  Eddlestone, Susan M ^a   Diniz, P P V P ^b   Neer, T M ^a   Gaunt, S D ^a   Corstvet, R ^a   Cho, D ^a   Hosgood, G ^a   Hegarty, B ^b   Breitschwerdt, E B ^b  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Canine ehrlichiosis; Immunofluorescence assay; Platelets; Polymerase chain reaction

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOG; DOG DISEASE; EHRLICHIA CANIS; EHRLICHIOSIS; RANDOMIZED CONTROLLED TRIAL;

ANIMALS; ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; DOG DISEASES; DOGS; DOXYCYCLINE; EHRLICHIA CANIS; EHRLICHIOSIS;

ANIMALIA; CANIS; CANIS FAMILIARIS; EHRLICHIA CANIS;

EID: 37349020065     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/07-061.1     Document Type: Article

References (16)

1. Iqbal Z, Rikihisa Y. Reisolation of Ehrlichia canis from blood and tissues of dogs after doxycycline treatment. J Clin Microbiol 1994;32:1644-1649.
2. Harrus S, Waner T, Aizenberg I. Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis: Evaluation of a 6-week course. J Clin Microbiol 1998:36, 2140-2142.
3. Neer TM, Breitschwerdt EB, Greene RT, et al. ACVIM consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM: American College of Veterinary Internal Medicine. J Vet Intern Med 2002;16: 309-315.
4. Gaunt SD, Corstvet RE, Berry CM, Brennan B. Isolation of Ehrlichia canis from dogs following subcutaneous inoculation. J Clin Microbiol 1996;34, 1429-1432.
5. Eddlestone SM, Neer TM, Gaunt SD, et al. Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs. J Vet Intern Med 2006;20:840-844.
6. Birkenheuer AJ, Levy MG, Breitschwerdt EB. Development and evaluation of a seminested PCR for detection and differentiation of Babesia gibsoni (Asian genotype) and B. canis DNA in canine blood samples. J Clin Microbiol 2003;41:4172-4177.
7. Breitschwerdt EB, Hegarty BC, Hancock SI. Sequential evaluation of dogs naturally infected with Ehrlichia canis, Ehrlichia chaffeensis, Ehrlichia equi, Ehrlichia ewingii, or Bartonella vinsonii. J Clin Microbiol 1998;36:2645-2651.
8. McBride JW, Yu X, Walker DH. A conserved, transcriptionally active p28 multigene locus of Ehrlichia canis. Gene 2000;254:245-252.
9. Gaunt S, Corstvet RD, Berry CM. Isolation of Ehrlichia canis from dogs following subcutaneous infection. J Clin Microbiol 1996;34:1429-1432.
10. Breitschwerdt EB, Hegarty BC, Hancock SI. Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains. Antimicrob Agents Chemother 1998;42:362-368.
11. Bartsch RC, Greene RT. Post-therapy antibody titers in dogs with ehrlichiosis: Follow-up study on 68 patients treated primarily with tetracycline and/or doxycycline. J Vet Intern Med 1996;10:271-274.
12. Harrus S, Kenny M, Miara L, et al. Comparison of simultaneous splenic sample PCR with blood sample PCR for diagnosis and treatment of experimental Ehrlichia canis infection. Antimicrob Agents Chemother 2004;48:4488-4490.
13. Frank JR, Breitschwerdt EB. A retrospective study of ehrlichiosis in 62 dogs from North Carolina and Virginia. J Vet Intern Med 1999;13:194-201.
14. O'Connor TP, Hanscom JL, Hegarty BC, et al. Comparison of an indirect immunofluorescence assay, Western blot analysis and a commercially available ELISA for detection of Ehrlichia canis antibodies in canine sera. Am J Vet Res 2006;67:206-210.
15. Chang W, Su W, Pan M. Two-step PCR in the evaluation of antibiotic treatment for Ehrlichia platys infection. J Vet Med Sci 1997;59:849-851.
16. Breitschwerdt EB, Blann KR, Stebbins ME, et al. Clinicopathologic abnormalities and treatment response in 24 dogs seroreactive to Bartonella vinsonii (berkhoffii) antigens. J Am Anim Hosp Assoc 2004;40:92-101.