Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs

Journal of Veterinary Internal Medicine

Volumn 21, Issue 6, 2007, Pages 1323-1331

  Coates, Joan R ^a,d   March, Philip A ^b,f   Oglesbee, Michael ^b   Ruaux, Craig G ^d   Olby, Natasha J ^c   Berghaus, Roy D ^e   O'Brien, Dennis P ^a   Keating, John H ^f   Johnson, Gary S ^a   Williams, David A ^d  

^a UNIVERSITY OF MISSOURI   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

^f TUFTS UNIVERSITY   (United States)

Author keywords

Ataxia; Axonopathy; Canine; Neurodegenerative; Oxidative stress; Spinal cord

Indexed keywords

DNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; DOG; DOG DISEASE; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; PEDIGREE; SPINAL CORD DISEASE;

ANIMALS; DNA; DOG DISEASES; DOGS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; MALE; PEDIGREE; SPINAL CORD DISEASES;

ANIMALIA; CANIS FAMILIARIS;

EID: 37349016576     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/07-059.1     Document Type: Article

References (45)

1. Averill DR Jr. Degenerative myelopathy in the aging German Shepherd dog: Clinical and pathologic findings. J Am Vet Med Assoc 1973;162:1045-1051.
2. Griffiths IR, Duncan ID. Chronic degenerative radiculomyelopathy in the dog. J Small Anim Pract 1975;16:461-471.
3. Longhofer SL, Duncan ID, Messing A. A degenerative myelopathy in young German shepherd dogs. J Small Anim Pract 1990;31:199-203.
4. Matthews NS, de Lahunta A. Degenerative myelopathy in an adult miniature poodle. J Am Vet Med Assoc 1985;186:1213-1215.
5. Bichsel P, Vandevelde M, Lang J, et al. Degenerative myelopathy in a family of Siberian husky dogs. J Am Vet Med Assoc 1983;183:998-1000.
6. Kneller SK, Oliver JE, Lewis RE. Differential diagnosis of progressive caudal paresis in an aged German Shepherd dog. J Am Anim Hosp Assoc 1975;11:414-417.
7. Braund KG. Hip dysplasia and degenerative myelopathy: Making the distinction in dogs. Veterinary Medicine 1987;August: 782-789.
8. Braund KG, Vandevelde M. German Shepherd dog myelopathy: A morphologic and morphometric study. Am J Vet Res 1978;39:1309-1315.
9. Caulkins SE, Purinton PT, Oliver JE Jr. Arterial supply to the spinal cord of dogs and cats. Am J Vet Res 1989;50:425-430.
10. Beal MF. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 1992;31:119-130.
11. Ilic TV, Jovanovic M, Jovicic A, et al. Oxidative stress indicators are elevated in de novo Parkinson's disease patients. Funct Neurol 1999;14:141-147.
12. Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995;38:357-366.
13. Olby N, Sharp NJH, Munana KR, et al. Chronic and acute compressive spinal cord lesions in dogs due to intervertebral disk herniation are associated with elevation in lumbar cerebrospinal fluid glutamate concentration. J Neurotrauma 1999;16:1215-1224.
14. Clemmons RM. Degenerative myelopathy. Vet Clin North Am Small Anim Pract 1992;22:965-971.
15. Shevell MI, Cooper BA, Rosenblatt DS. Inherited disorders of cobalamin and folate transport and metabolism. In: Rosenberg RN, Prusiner SB, DiMauro S, et al. eds. The Molecular and Genetic Basis of Neurological Disease. Boston, MA: Butterworth-Heinemann; 1997:1301-1321.
16. Mayhew IG, Brown CM, Stowe HD, et al. Equine degenerative myeloencephalopathy: A vitamin E deficiency that may be familial. J Vet Intern Med 1987;1:45-50.
17. Sokol RJ. Vitamin E and neurologic function in man. Free Radic Biol Med 1989;6:189-207.
18. Scott JM, Dinn JJ, Wilson P, et al. Pathogenesis of subacute combined degeneration: A result of methyl group deficiency. Lancet 1981;2:334-337.
19. Dinn JJ, McCann S, Wilson P, et al. Animal model for subacute combined degeneration. Lancet 1978;2:1154.
20. Johnston PEJ, Knox K, Gettinby G, et al. Serum α-tocopherol concentrations in German shepherd dogs with chronic degenerative radiculomyelopathy. Vet Rec 2001;148: 403-407.
21. Johnston PEJ, Barrie JA, McCulloch MC, et al. Central nervous system pathology in 25 dogs with chronic degenerative radiculomyelopathy. Vet Rec 2000;146:629-633.
22. Clemmons RM. Therapeutic considerations for degenerative myelopathy of German Shepherds. American College of Veterinary Internal Medicine 9th Forum, New Orleans, LA, May 1991;773-775.
23. Tan SV, Guiloff RJ. Hypothesis on the pathogenesis of vacuolar myelopathy, dementia, and peripheral neuropathy in AIDS. J Neurol Neurosurg Psychiatry 1998;65:23-28.
24. Ischiropoulos H, Beckman JS. Oxidative stress and nitration in neurodegeneration: Cause, effect, or association. J Clin Invest 2003;111:163-169.
25. Kimura J. Types of electromyographic abnormalities. In: Kimura J, ed. Electrodiagnosis in Diseases of Nerve and Muscle. New York, NY: Oxford University Press; 2001:339-369.
26. Walker TL, Redding RW, Braund KG. Motor nerve conduction velocity and latency in the dog. Am J Vet Res 1979;40:1433-1439.
27. Levine JM, Hillman RB, Erb HN, et al. The influence of age on patellar reflex response in the dog. J Vet Intern Med 2002;16:244-246.
28. Griffiths IR, Duncan ID. Age changes in the dorsal and ventral lumbar nerve roots of dogs. Acta Neuropathol (Berl) 1975;32:75-85.
29. Hoerlein BF. Intervertebral disc disease. In: Hoerlein BF, ed. Canine Neurology: Diagnosis and Treatment. Philadelphia, PA: WB Saunders; 1978:470-560.
30. Hansen HJ. A pathologic-anatomical study on disc degeneration in dog. Acta Orthop Scand Suppl 1952;11:1-117.
31. Jenkins TW. Functional Mammalian Neuroanatomy, 2nd ed. Philadelphia, PA: Lea and Febiger; 1978:
32. de Lahunta A. Veterinary Neuroanatomy and Clinical Neurology, 2nd ed. Philadelphia, PA: WB Saunders; 1983:
33. Amassian VE. Fiber groups and spinal pathways of cortically represented visceral afferents. J Physiol (Lond) 1951;14: 445-460.
34. Al-Chaer ED, Lawand NB, Westlund KN, et al. Pelvic visceral input into the nucleus gracilis is largely mediated by the postsynaptic dorsal column pathway. J Neurophysiol 1996;76: 2675-2690.
35. Willis WD, Al-Chaer ED, Quast MJ, et al. A visceral pain pathway in the dorsal column of the spinal cord. Proceed Natl Acad Sci USA 1999;96:7675-7679.
36. Waxman FJ, Clemmons RM, Johnson G, et al. Progressive myelopathy in older German shepherd dogs. I. Depressed response to thymus-dependent mitogens. J Immunol 1980;124: 1209-1215.
37. Waxman FJ, Clemmons RM, Hinrichs DJ. Progressive myelopathy in older German shepherd dogs. II. Presence of circulating suppressor cells. J Immunol 1980;124:1216-1222.
38. Clemmons RM. Degenerative myelopathy. In: Kirk RW, ed. Current Veterinary Therapy X: Small Animal Practice. Philadelphia, PA: WB Saunders; 1989:830-833.
39. Barclay KB, Haines DM. Immunohistochemical evidence for immunoglobulin and complement deposition in spinal cord lesions in degenerative myelopathy in German shepherd dogs. Can J Vet Res 1994;58:20-24.
40. Fechner H, Johnston PE, Sharp NJH, et al. Molecular genetic and expression analysis of alpha-tocopherol transfer protein mRNA in German Shepherd dogs with degenerative myelopathy. Berliner und Munchener Tierarzliche Wochenschrift 2003;116:31-36.
41. Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem 1992;59:1609-1623.
42. Auer RN, Siesjo BK. Biological differences between ischemia, hypoglycemia, and epilepsy. Ann Neurol 1988;24:699-707.
43. Greco A, Minghetti L, Sette G, et al. Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis. Neurology 1999;53:1876-1879.
44. Montine TJ, Beal MF, Cudkowicz ME, et al. Increased CSF F2-isoprostane concentration. Neurology 1999;52:562-565.
45. Morrow JD, Roberts LJ. The isoprostanes: Unique bioactive products of lipid peroxidation. Prog Lipid Res 1997;36:1-21.