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Volumn 46, Issue 24, 2007, Pages 10114-10119

Conformational change induced by metal-ion-binding to DNA containing the artificial 1,2,4-triazole nucleoside

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; DNA; NUCLEOSIDE; OLIGONUCLEOTIDE; SILVER; THYMINE; TRIAZOLE DERIVATIVE;

EID: 37249093936     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic700884q     Document Type: Article
Times cited : (62)

References (60)
  • 44
    • 33845662163 scopus 로고    scopus 로고
    • (c) Müller, J. Nature 2006, 444, 698.
    • (2006) Nature , vol.444 , pp. 698
    • Müller, J.1
  • 52
    • 37249051149 scopus 로고    scopus 로고
    • 2+ (refs 8 and 9), the undesired formation of such adducts might also be responsible for the observed destabilization.
    • 2+ (refs 8 and 9), the undesired formation of such adducts might also be responsible for the observed destabilization.
  • 53
    • 37249044985 scopus 로고    scopus 로고
    • One equiv of metal ions represents the amount that is necessary for the formation of a regular double helix in which each potential metal-ion-mediated base pair contains one metal ion
    • One equiv of metal ions represents the amount that is necessary for the formation of a regular double helix in which each potential metal-ion-mediated base pair contains one metal ion.
  • 54
    • 37249075681 scopus 로고    scopus 로고
    • The labeled oligonucleotides A, B, and C cannot be used to confirm the conformational change. In these, the fluorescein and dabcyl moieties stabilize the hairpin conformation to such an extent, that no regular double helix is formed upon the addition of silver(I). This can be seen for example from the concentration-independent melting temperature of C (Supporting Information, Figure S2).
    • The labeled oligonucleotides A, B, and C cannot be used to confirm the conformational change. In these, the fluorescein and dabcyl moieties stabilize the hairpin conformation to such an extent, that no regular double helix is formed upon the addition of silver(I). This can be seen for example from the concentration-independent melting temperature of C (Supporting Information, Figure S2).
  • 58
    • 37249068734 scopus 로고    scopus 로고
    • The hydrodynamic radius does not double when the length of the oligonucleotide doubles because it merely represents the radius of a hypothetic hard spherical particle that diffuses with the same speed as the particle under examination. Whereas short hairpins can accurately be described as spherical particles, double helices should rather be considered as short, rodlike molecules.[27] Hence, the hydrodynamic radii of the latter are always smaller than half of the length of their long axes
    • [27] Hence, the hydrodynamic radii of the latter are always smaller than half of the length of their long axes.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.