Acute hepatic injury in four children with Dravet syndrome: Valproic acid, topiramate or acetaminophen?

Seizure

Volumn 17, Issue 1, 2008, Pages 92-97

  Nicolai, Joost ^a   Gunning, Boudewijn ^b   Leroy, Piet L ^a   Ceulemans, Berten ^c   Vles, Johan S H ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b EPILEPSY CENTER KEMPENHAEGHE   (Netherlands)

^c Epilepsy Center for Children and Youth   (Belgium)

Author keywords

Acetaminophen; Dravet syndrome; Liver toxicity; Stiripentol; Topiramate; Valproate

Indexed keywords

CARBAMAZEPINE; CARNITINE; CLOBAZAM; CLONAZEPAM; DRUG METABOLITE; LACTULOSE; LAMOTRIGINE; LIVER ENZYME; PARACETAMOL; TOPIRAMATE; VALPROIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMMONIA BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CLOTTING DISORDER; CASE REPORT; DISEASE COURSE; DRAVET SYNDROME; DRUG ACCUMULATION; DRUG EFFECT; DRUG WITHDRAWAL; ENZYME BLOOD LEVEL; EPILEPTIC STATE; FEVER; HUMAN; INFANT; INTERNATIONAL NORMALIZED RATIO; LIVER INJURY; LIVER TOXICITY; MALE; MYOCLONUS EPILEPSY; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; SIDE EFFECT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTICONVULSANTS; DEVELOPMENTAL DISABILITIES; DRUG THERAPY, COMBINATION; ENZYMES; FEMALE; FRUCTOSE; HEPATITIS, TOXIC; HUMANS; INFANT; INFLUENZA, HUMAN; LIVER FUNCTION TESTS; MALE; MYOCLONIC EPILEPSY, JUVENILE; NERVE TISSUE PROTEINS; SODIUM CHANNELS; SYNDROME; VALPROIC ACID;

EID: 37249088025     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2007.07.003     Document Type: Article

References (22)

1. Bohan T.P., Helton E., McDonald I., Konig S., Gazitt S., Sugimoto T., et al. Effect of l-carnitine treatment for valproate-induced hepatotoxicity. Neurology 56 (2001) 1405-1409
2. Bryant A.E., and Dreifuss F.E. Valproic acid hepatic fatalities. III. U.S. experience since 1986. Neurology 46 (1996) 465-469
3. Bjoro K., Gjerstad L., Bentdal O., Osnes S., and Schrumpf E. Topiramate and fulminant liver failure. Lancet 352 (1998) 1119
4. Doan R.J., and Clendenning M. Topiramate and hepatotoxicity. Can J Psychiat 45 (2000) 937-938
5. Watkins P.B., Kaplowitz N., Slattery J.T., Colonese C.R., Colucci S.V., Stewart P.W., et al. Aminotransferase elevations in healthy adults receiving 4 g of acetaminophen daily. J Am Med Assoc 296 (2006) 87-93
6. DeVivo D.C., Bohan T.P., Coulter D.L., Dreifuss F.E., Greenwood R.S., Nordli Jr. D.R., et al. l-carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia 39 (1998) 1216-1225
7. Raskind J.Y., and El-Chaar G.M. The role of carnitine supplementation during valproic acid therapy. Ann Pharmacother 34 (2000) 630-638
8. Chiron C., Marchand M.C., Tran A., Rey E., d'Athis P., Vincent J., et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomized placebo-controlled syndrome-dedicated trial STICLO study group. Lancet 356 (2000) 1638-1642
9. Coppola G., Campovilla G., Montagnini A., Federico R.R., Resicato G., and Pascotto A. Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial. Epilepsy Res 49 (2002) 45-48
10. Kröll-Seger J., Portilla P., Dulac O., and Chiron C. Topiramate in the treatment of highly refractory patients with Dravet syndrome. Neuropediatrics 37 (2006) 325-329
11. Ceulemans B., Boel M., Claes L., Dom L., Willekens H., Thiry P., et al. Severe myoclonic epilepsy in infancy: toward an optimal treatment. J Child Neurol 19 (2004) 516-521
12. Coppola G., Epifanio G., Auricchio G., Federico R.R., Resicato G., and Pascotto A. Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet. Brain Dev 28 (2006) 358-365
13. Tein I. Role of carnitine and fatty acid oxidation and its defects in infantile epilepsy. J Child Neurol 17 Suppl 3 (2002) S57-S82
14. Murphy J.V., Groover R.V., and Hodge C. Hepatotoxic effects in a child receiving valproate and carnitine. J Pediatr 123 (1993) 318-320
15. Grosso S., Franzoni E., Iannetti P., Cardinali C., Toldo I., Verrotti A., et al. Efficacy and safety of topiramate in refractory epilepsy of childhood: long-term follow-up study. J Child Neurol 20 (2005) 893-897
16. Longin E., Teich M., Koelfen W., and Konig S. Topiramate enhances the risk of valproate-associated side effects in three children. Epilepsia 43 (2003) 451-454 Erratum Epilepsia 2002; 43:1110
17. Bumb A., Diederich N., and Beyenburg S. Adding topiramate to valproate therapy may cause reversible hepatic failure. Epileptic Disord 5 (2003) 157-159
18. Tran A., Tréluyer J.M., Rey E., Barbet J., Ferracci G., d'Athis J., et al. Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat. Toxicol Appl Pharmacol 170 (2001) 145-152
19. Kozer E., Greenberg R., Zimmerman D.R., and Berkovitch M. Repeated supratherapeutic doses of paracetamol in children-a literature review and suggested clinical approach. Acta paediatr 95 (2006) 1165-1171
20. Jalan R., Williams R., and Bernuau J. Paracetamol: are therapeutic doses entirely safe?. Lancet 368 (2006) 2195-2196
21. Hamer H.M., Knake S., Schomburg U., and Rosenow F. Valproate-induced hyperammonemic encephalopathy in the presence of topiramate. Neurology 54 (2000) 230-232
22. Latour P., Biraben A., Polard E., Bentue-Ferrer D., Beauplet A., Tribut O., et al. Drug induced encephalopathy in six epileptic patients: topiramate? valproate? or both?. Hum Psychopharmacol 19 (2004) 193-203