Evaluation of the deformation behavior of binary systems of methacrylic acid copolymers and hydroxypropyl methylcellulose using a compaction simulator

International Journal of Pharmaceutics

Volumn 348, Issue 1-2, 2008, Pages 46-53

  Tatavarti, Aditya S ^a   Muller, Francis X ^a,b   Hoag, Stephen W ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Compaction; Eudragit ; HPMC; Methacrylic acid; pH modulating; Tablets

Indexed keywords

EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; POLYMETHACRYLIC ACID;

ARTICLE; CHEMICAL BOND; DRUG SCREENING; POROSITY; PRIORITY JOURNAL; SIMULATOR;

ACRYLIC RESINS; ELASTICITY; MECHANICS; METHYLCELLULOSE; MICROSCOPY; POLYMETHACRYLIC ACIDS; POWDERS; PRESSURE; STRESS, MECHANICAL; TABLETS; VEHICLES;

EID: 37249047889     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.07.002     Document Type: Article

References (28)

1. Cameron C.G., and McGinity J.W. Controlled-release theophylline formulations containing acrylic resins. II. Combination resin formulations. Drug Dev. Ind. Pharm. 13 (1987) 1409-1427
2. Cameron C.G., and McGinity J.W. Controlled-release theophylline formulations containing acrylic resins. III. Influence of filler excipients. Drug Dev. Ind. Pharm. 13 (1987) 303-318
3. Carstensen J.T., Ertell C., and Danjo K. Effect of compaction speed and die diameter on Athy-Heckel and hardness parameters of compressed tablets. Drug Dev. Ind. Pharm. 15 (1989) 1-10
4. Celik M., and Marshall K. Use of a compaction simulator system in tableting research. Drug Dev. Ind. Pharm. 15 (1989) 759-800
5. Farhadieh B., Borodkin S., and Buddenhagen J.D. Drug Release from methyl acrylate-methyl methacrylate copolymer matrix. I. Kinetics of release. J. Pharm. Sci. 60 (1971) 209-212
6. Garr J.S.M., and Rubinstein M.H. An investigation into the capping of paracetmol at increasing speeds of compression. Int. J. Pharm. 72 (1991) 117-122
7. Heckel R.W. Density-pressure relationships in powder compression. Trans. Metall. Soc. AIME 221 (1961) 671-675
8. Hoag S.W., Nair R., and Muller F.X. Force-transducer design optimization for the measurement of die-wall stress in a compaction simulator. Pharm. Pharmacol. Commun. 6 (2000) 1-6
9. Ilkka J., and Paronen P. Prediction of the compression behavior of powder mixtures by the Heckel equation. Int. J. Pharm. 94 (1993) 181-187
10. Kiekens F., Debunne A., Vevaet C., Baert L., Vanhoutte F., Assche I.V., Menard F., and Remon J.P. Influence of the punch diameter and curvature on the yield pressure of MCC-compacts during Heckel analysis. Eur. J. Pharm. Sci. 22 (2004) 117-126
11. Kottke, and Rudnic. Tablet Dosage Forms in Modern Pharmaceutics vol. 121 (2002), Dekker, New York p. 317
12. McGinity J.W., Cameron C.G., and Cuff G.W. Controlled-release theophylline formulations containing acrylic resins. I. Dissolution properties of tablets. Drug Dev. Ind. Pharm. 9 (1983) 57-68
13. Muller F.X., and Augsburger L.L. The role of the displacement-time waveform in the determination of Heckel behavior under dynamic conditions in a compaction simulator and a fully instrumented rotary tablet machine. J. Pharm. Pharmacol. 46 (1994) 468-475
14. Narayan P., and Hancock B.C. The relationship between the particle properties, mechanical behavior, and surface roughness of some pharmaceutical excipient compacts. Mater. Sci. Eng. A 355 (2003) 24-36
15. Nokhodchi A., Rubinstein M.H., and Ford J.L. The effect of particle size and viscosity grade on the compaction properties of hydroxypropyl methylcellulose 2208. Int. J. Pharm. 126 (1995) 189-197
16. Nokhodchi A., Ford J.L., Rowe P.H., and Rubinstein M.H. The effect of compression rate and force on the compaction properties of different viscosity grades of hydroxypropylmethylcellulose 2208. Int. J. Pharm. 129 (1996) 21-31
17. Oren, P.L., Seidler, W.M.K., 1990. Sustained release matrix. US patent 4,968,508.
18. Pedersen S., and Kristensen H.G. Change in crystal density of acetylsalicylic acid during compaction. STP Pharma Sci. 4 (1994) 201-206
19. Roberts R.J., and Rowe R.C. The effect of punch velocity on the compaction of a variety of materials. J. Pharm. Pharmacol. 37 (1985) 377-384
20. Roberts R.J., and Rowe R.C. The effect of the relationship between punch velocity and particle size on the compaction behaviour of materials with varying deformation mechanisms. J. Pharm. Pharmacol. 38 (1986) 567-571
21. Roberts R.J., Rowe R.C., and Kendall K. Brittle-ductile transitions in die compaction of sodium chloride. Chem. Eng. Sci. 44 (1989) 1647-1651
22. Schulze M.D., and McGinity J.W. Indices of tableting performance for acrylic resin polymers with plastic and brittle drugs. Drug Dev. Ind. Pharm. 19 (1993) 1393-1411
23. Schulze M.D., Williams III R.O., and McGinity J.W. Compaction properties of acrylic resin polymers with plastic and brittle drugs. Drug Dev. Ind. Pharm. 16 (1990) 741-754
24. Sonnergaard J.M. A critical evaluation of the Heckel equation. Int. J. Pharm. 193 (1999) 63-71
25. Sun C., and Grant D.J. Influence of elastic deformation of particles on Heckel analysis. Pharm. Dev. Technol. 6 (2001) 193-200
26. Takka S., Rajbhandari S., and Sakr A. Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. Eur. J. Pharm. Biopharm. 52 (2001) 75-82
27. Tatavarti A.S., and Hoag S.W. Microenvironmental pH modulation based release enhancement of a weakly basic drug from hydrophilic matrices. J. Pharm. Sci. 95 (2006) 1459-1468
28. Tatavarti A.S., Mehta K.A., Augsburger L.L., and Hoag S.W. Influence of methacrylic and acrylic acid polymers on the release performance of weakly basic drugs from sustained release hydrophilic matrices. J. Pharm. Sci. 93 (2004) 2319-2331