A functionally coupled μ3-like opiate receptor/nitric oxide regulatory pathway in human multi-lineage progenitor cells

Journal of Immunology

Volumn 179, Issue 9, 2007, Pages 5839-5844

  Cadet, Patrick ^a   Mantione, Kirk J ^a   Zhu, Wei ^a   Kream, Richard M ^a   Sheehan, Melinda ^a   Stefano, George B ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METENKEPHALIN; MORPHINE; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE; OPIATE ANTAGONIST; OPIATE RECEPTOR; RECEPTOR SUBTYPE; MU OPIATE RECEPTOR;

ARTICLE; BRAIN NERVE CELL; CELL FUNCTION; CONTROLLED STUDY; CULTURAL ANTHROPOLOGY; DIFFERENTIATION; EMBRYO DEVELOPMENT; GENETIC CONSERVATION; HUMAN; MICROARRAY ANALYSIS; MOTIVATION; PRECAMBRIAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; UMBILICAL CORD BLOOD; CELL DIFFERENTIATION; CELL LINEAGE; CYTOLOGY; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; SECRETION; SIGNAL TRANSDUCTION; TIME;

BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BINDING; RECEPTORS, OPIOID, MU; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS; TIME FACTORS;

EID: 37249044000     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.9.5839     Document Type: Article

References (38)

1. Zamir, N., R. Quirion, and M. Segal. 1985. Ontogeny and regional distribution of proenkephalin- and prodynorphin-derived peptides and opioid receptors in rat hippocampus. Neuroscience 15: 1025-1034.
2. Leslie, F. M., Y. Chen, and U. H. Winzer-Serhan. 1998. Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system. Can. J. Physiol. Pharmacol. 76: 284-293.
3. Zhu, Y., M. S. Hsu, and J. E. Pintar. 1998. Developmental expression of the μ, κ, and δ opioid receptor mRNAs in mouse. J. Neurosci. 18: 2538-2549.
4. Ventura, C., and M. Maioli. 2000. Opioid peptide gene expression primes cardiogenesis in embryonal pluripotent stem cells. Circ. Res. 87: 189-194.
5. Kim, E., A. L. Clark, A. Kiss, J. W. Hahn, R. Wesselschmidt, C. J. Coscia, and M. M. Belcheva. 2006. μ- and κ-opioids induce the differentiation of embryonic stem cells to neural progenitors. J. Biol. Chem. 281: 33749-33760.
6. McGuckin, C. P., N. Forraz, Q. Allouard, and R. Pettengell. 2004. Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro. Exp. Cell Res. 295: 350-359.
7. th Annual International Umbilical Cord Blood Transplantation Symposium, May 19-20. St. Paul, MN.
8. McGuckin, C. P., N. Forraz, M. O. Baradez, S. Navran, J. Zhao, R. Urban, R. Tilton, and L. Denner. 2005. Production of stem cells with embryonic characteristics from human umbilical cord blood. Cell Prolif. 38: 245-255.
9. McGuckin, C., N. Forraz, M. O. Baradez, C. Basford, A. M. Dickinson, S. Navran, and J. D. Hartgerink. 2006. Embryonic-like stem cells from umbilical cord blood and potential for neural modeling. Acta Neurobiol. Exp. 66: 321-329.
10. Forraz, N., R. Pettengell, and C. P. McGuckin. 2004. Characterization of a lineage-negative stem-progenitor cell population optimized for ex vivo expansion and enriched for LTC-IC. Stem Cells 22: 100-108.
11. Goodwin, H. S., A. R. Bicknese, S. N. Chien, B. D. Bogucki, C. O. Quinn, and D. A. Wall. 2001. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol. Blood Marrow Transplant. 7: 581-588.
12. Lee, O. K., T. K. Kuo, W. M. Chen, K. D. Lee, S. L. Hsieh, and T. H. Chen. 2004. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103: 1669-1675.
13. Horowitz, D., J. F. Callahan, L. M. Pelus, S. Fukuda, and A. G. King. 2002. Inhibition of hematopoietic progenitor cell growth by Tyr-MIF, an endogenous opiate modulator, and its degradation products. Int. Immunopharmacol. 2: 721-730.
14. Rameshwar, P., A. Poddar, and P. Gascon. 1997. Hematopoietic regulation mediated by interactions among the neurokinins and cytokines. Leuk. Lymphoma. 28: 1-10.
15. Broome, C. S., A. D. Whetton, and J. A. Miyan. 2000. Neuropeptide control of bone marrow neutrophil production is mediated by both direct and indirect effects on CFU-GM. Br. J. Haematol. 108: 140-150.
16. Sharp, B. M., S. Roy, and J. M. Bidlack. 1998. Evidence for opioid receptors on cells involved in host defense and the immune system. J. Neuroimmunol. 83: 45-56.
17. Stefano, G. B., A. Digenis, S. Spector, M. K. Leung, T. V. Bilfinger, M. H. Makman, B. Scharrer, and N. N. Abumrad. 1993. Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression. Proc. Natl. Acad. Sci. USA 90: 11099-11103.
18. Makman, M. H., T. V. Bilfinger, and G. B. Stefano. 1995. Human granulocytes contain an opiate receptor mediating inhibition of cytokine-induced activation and chemotaxis. J. Immunol. 154: 1323-1330.
19. 3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation. J. Biol. Chem. 270: 30290-30293.
20. 3, a novel alternatively spliced variant of the human μ opiate receptor gene. J. Immunol. 170: 5118-5123.
21. Cadet, P., K. J. Mantione, T. V. Bilfinger, and G. B. Stefano. 2004. Differential expression of the human 7mu; opiate receptor from different primary vascular endothelial cells. Med. Sci. Monit. 10: BR351-BR355.
22. Prevot, V., C. Rialas, D. Croix, M. Salzet, J.-P. Dupouy, P. Puolain, J. C. Beauvillain, and G. B. Stefano. 1998. Morphine and anandamide coupling to nitric oxide stimulated GnRH and CRF release from rat median eminence: neurovascular regulation. Brain Res. 790: 236-244.
23. Madhusoodanan, K. S., and F. Murad. 2007. NO-cGMP signaling and regenerative medicine involving stem cells. Neurochem. Res. 32: 681-694.
24. Zhu, W., K. J. Mantione, L. Shen, P. Cadet, T. Esch, Y. Goumon, E. Bianchi, D. Sonetti, and G. B. Stefano. 2005. Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: CYP2D6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling. Med. Sci. Monit. 11: BR397-BR404.
25. Zhu, W., P. Cadet, G. Baggerman, K. J. Mantione, and G. B. Stefano. 2005. Human white blood cells synthesize morphine: CYP2D6 modulation. J. Immunol. 175: 7357-7362.
26. Mantione, K. J., P. Cadet, W. Zhu, R. M. Kream, M. Sheehan, G. L. Fricchione, Y. Goumon, T. Esch, and G. B. Stefano. 2007. Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition. Addict. Biol. doi: 10.111/j.1369-1600.2007.00072.X.
27. 3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation. J. Biol. Chem. 270: 30290-30293.
28. Magazine, H. I., Y. Liu, T. V. Bilfinger, G. L. Fricchione, and G. B. Stefano. 1996. Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. J. Immunol. 156: 4845-4850.
29. Liu, Y., D. Shenouda, T. V. Bilfinger, M. L. Stefano, H. I. Magazine, and G. B. Stefano. 1996. Morphine stimulates nitric oxide release from invertebrate microglia. Brain Res. 722: 125-131.
30. Stefano, G. B., B. Scharrer, E. M. Smith, T. K. Hughes, H. I. Magazine, T. V. Bilfinger, A. Hartman, G. L. Fricchione, Y. Liu, and M. H. Makman. 1996. Opioid and opiate immunoregulatory processes. Crit. Rev. Immunol. 16: 109-144.
31. 3 opiate receptor in invertebrate neural tissues. Comp. Biochem. Physiol. C 113: 369-373.
32. Cadet, P., T. V. Bilfinger, C. Fimiani, D. Peter, and G. B. Stefano. 2000. Human vascular and cardiac endothelia express μ opiate receptor transcripts. Endothelium 7: 185-191.
33. Sonetti, D., E. Ottaviani, and G. B. Stefano. 1997. Opiate signaling regulates microglia activities in the invertebrate nervous system. Gen. Pharmacol. 29: 39-47.
34. Matthes, H. W., R. Maldonado, F. Simonin, O. Valverde, S. Slowe, I. Kitchen, K. Befort, A. Dierich, M. Le meur, P. Dollé, et al. 1996. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ opioid receptor gene. Nature 383: 819-823.
35. Mujoo, K., J. S. Krumenacker, Y. Wada, and F. Murad. 2006. Differential expression of nitric oxide signaling components in undifferentiated and differentiated human embryonic stem cells. Stem Cells Dev. 15: 779-787.
36. Torroglosa, A., M. Murillo-Carretero, C. Romero-Grimaldi, E. R. Matarredona, A. Campos-Caro, and C. Estrada. 2007. Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway. Stem Cells 25: 88-97.
37. Kream, R. M., and G. B. Stefano. 2006. De novo biosynthesis of morphine in animal cells: an evidence-based model. Med. Sci. Monit. 12: RA207-RA219.
38. Kream, R. M., and G. B. Stefano. 2006. Morphine synthesis in animals (Editorial). Med. Sci. Monit. 12: ED1-ED2.