Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones

Organic Letters

Volumn 9, Issue 25, 2007, Pages 5259-5262

  Jin, Tienan ^a   Yamamoto, Yoshinori ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 37249012791     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol702455v     Document Type: Article

References (39)

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36. 6 catalyst, other substrates (1c-m) did not give good results even upon increasing the catalyst loading to 15 mol % under the longer reaction times (24 h, the starting materials were recovered in comparable yields.).
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39. 8-Phenyl-7-octyn-3-one produced a complex mixture of products including 2-ethyl-1-cyclopentenyl(phenyl)methanone (∼10%). The cycloisomerization to five-membered enone was difficult: the reason is not clear at present.