Production of anti-epithelial antibodies and acantholysis by vaccination with an anti-idiotypic antibody, mimicking desmoglein 1

Experimental Dermatology

Volumn 17, Issue 1, 2008, Pages 44-48

  Avalos díaz, Esperanza ^a   López robles, Eréndira ^a   Alvarado flores, Ernesto ^a   Herrera esparza, Rafael ^a,b  

^a UNIVERSIDAD AUTÓNOMA DE ZACATECAS   (Mexico)

^b NONE   (Mexico)

Author keywords

Anti desmoglein; Anti idiotype; Pemphigus; Vaccination

Indexed keywords

DESMOGLEIN 1; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; PEMPHIGUS ANTIBODY; PEPSIN A;

ACANTHOLYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; BLISTER; CONTROLLED STUDY; EPIDERMIS; GEL FILTRATION CHROMATOGRAPHY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PEMPHIGUS; SEROLOGY; SKIN BIOPSY;

ACANTHOLYSIS; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODY SPECIFICITY; AUTOANTIBODIES; DESMOGLEIN 1; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MICE, INBRED BALB C; RABBITS; VACCINATION; VACCINES;

EID: 37249010525     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2007.00631.x     Document Type: Article

References (22)

1. Kunkel H G, Mannik M, Williams R C. Individual antigenic specificity of isolated antibodies. Science 1963: 140: 1218-1219.
2. Jerne N K, Roland J, Cazenave P A. Recurrent idiotypes and internal images. EMBO J 1982: 2: 243-247.
3. Lamoyi E, Estess P, Capra D, Nisonoff A. Presence of highly conserved idiotype determinants in a family of antibodies that constitute an intrastrain cross-reactive idiotype. J Exp Med 1980: 152: 703-711.
4. Nisonoff A, Lamoyi E. Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine production. Clin Immunol Immunopathol 1981: 21: 397-405.
5. Goldbaum F A, Velikovsky C A, Dall'Acqua W et al. Characterization of anti-anti-idiotypic antibodies that bind antigen and an anti-idiotype. PNAS 1997: 94: 8697-8701.
6. Stanley J R, Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med 2006: 355: 1800-1810.
7. Amagai M, Ahmed A R, Kitajima Y etal. Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just "witnesses of disease"? Exp Dermatol 2006: 15: 815-831.
8. Anhalt G J, Labib R S, Voorhees J J, Beals T F, Diaz L A. Induction of pemphigus in neonatal mice passive transfer of IgG from patients with the disease. N Engl J Med 1982: 306: 1189-1196.
9. Aoki-Ota M, Tsunoda K, Ota T et al. A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice. Br J Dermatol 2004: 151: 346-354.
10. Avalos-Diaz E, Olague-Marchan M, Lopez-Swiderski A, Herrera-Esparza R, Diaz LA. Transplacental passage of maternal pemphigus foliaceous autoantibodies induces neonatal pemphigus. J Am Acad Dermatol 2000: 43: 1130-1134.
11. Alvarado-Flores E, Avalos-Diaz E, Diaz LA, Herrera-Esparza R. Anti-idiotype antibodies neutralize in vivo the blistering effect of pemphigus foliaceous IgG. Scand J Immunol 2001: 53: 254-258.
12. Herrera-Esparza R, Swaak T, Aarden L, Smeek R. Complement-fixing antibodies to dsDNA detected by the immunofluorescence technique on Crithidia luciliae. A critical appraisal. J Rheumatol 1985: 12: 1109-1117.
13. Zagorodniuk I, Weltfriend S, Shtruminger L et al. A comparison of anti-desmoglein antibodies and indirect immunofluorescence in the serodiagnosis of pemphigus vulgaris. Int J Dermatol 2005: 44: 541-544.
14. Diaz L A, Arteaga L A, Hilario-Vargas J et al. Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and Chagas disease suggest a possible etiological link to Fogo selvagem. J Invest Dermatol 2004: 123: 1045-1051.
15. Laemmli U K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970: 277: 680-685.
16. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 1979: 76: 4350-4354.
17. Rico M J, White L D S, Hall R P. Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid. J Invest Dermatol 1993: 100: 766-770.
18. Richard C, Gilbert D, Delpech A, Lauret P, Joly P, Tron F. Production of anti-idiotype antibodies in pemphigus. J Invest Dermatol 1997: 109: 418 (abstract 85).
19. Sulzer B, van Hemmen J L. Adaptive control: A strategy to treat autoimmunity. J Theor Biol 1999: 7: 73-79.
20. Gurish M F, Ben-Porat T, Nisonoff A. Induction of antibodies to pseudorabies virus by immunization with antiidiotypic antibodies. Ann Inst Pasteur Immunol 1988: 139: 677-687.
21. Ullenhag G J, Spendlove I, Watson N F et al. A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55. Clin Cancer Res 2006: 15: 7389-7396.
22. Pfisterer J, du Bois A, Sehouli J et al. The anti-idiotypic antibody abagovomab in patients with recurrent ovarian cancer. A phase I trial of the AGO-OVAR. Ann Oncol 2006: 17: 1568-1577.