Detection of JAK2V617F mutation in patients with myeloproliferative disorders with TaqMan-MGB probe

National Medical Journal of China

Volumn 87, Issue 34, 2007, Pages 2401-2404

  Ruan, Guo Rui ^a   Chen, Shan Shan ^a   Li, Ling Di ^a   Liu, Yan Rong ^a   Qin, Ya Zhen ^a   Li, Jin Lan ^a   Ma, Xi ^a   Wang, Feng Rong ^a   Jiang, Qian ^a   Jiang, Bin ^a   Liu, Kai Yan ^a   Huang, Xiao Jun ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

JAK2; Mutation; Myeloproliferative disorders; Polymerase chain reaction

Indexed keywords

COMPLEMENTARY DNA; GENOMIC DNA; GENOMIC RNA; JANUS KINASE 2; PHENYLALANINE; VALINE;

ACCURACY; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHINESE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA EXTRACTION; GENE MUTATION; GENE SEQUENCE; HUMAN; MAJOR CLINICAL STUDY; MUTANT; MUTATIONAL ANALYSIS; MYELOID METAPLASIA; MYELOPROLIFERATIVE DISORDER; NONHODGKIN LYMPHOMA; NUCLEOTIDE SEQUENCE; POLYCYTHEMIA VERA; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA EXTRACTION; THROMBOCYTHEMIA;

ADULT; AMINO ACID SUBSTITUTION; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA PROBES; HUMANS; JANUS KINASE 2; MOLECULAR SEQUENCE DATA; MUTATION; MYELOPROLIFERATIVE DISORDERS; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS;

EID: 37149038826     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Baxter EJ, Scott LM, Campbell PJ, et al. Cancer Genome Project, Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet, 2005, 365:1054-1061.
2. Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid. metaplasia with myelofibrosis. Cancer Cell, 2005, 7:387-397.
3. Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med, 2005, 352:1779-1790.
4. Jones AV, Kreil S, Zoi K, et al. Widespread occurrence of the JAK2 V617F mutation in myeloproliferative disorders. Blood, 2005, 106:2162-2168.
5. Lippert E, Boissinot M, Kralovics R, et al. The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera. Blood, 2006, 108:1865-1867.
6. Chinese source.
7. Levine RL, Belisle C, Wadleigh M, et al. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood, 2006, 107: 4139-4141.
8. Chinese source.