-
1
-
-
2342573235
-
Trends in waist circumference among U.S. adults
-
Ford ES, Mokdad AH, Giles WH: Trends in waist circumference among U.S. adults. Obes Res 11:1223-1231, 2003
-
(2003)
Obes Res
, vol.11
, pp. 1223-1231
-
-
Ford, E.S.1
Mokdad, A.H.2
Giles, W.H.3
-
2
-
-
33846702984
-
Should central obesity be an optional or essential component of the metabolic syndrome? Ischemic heart disease risk in the Singapore Cardiovascular Cohort Study
-
Lee J, Ma S, Heng D, Tan CE, Chew SK, Hughes K, Tai ES: Should central obesity be an optional or essential component of the metabolic syndrome? Ischemic heart disease risk in the Singapore Cardiovascular Cohort Study. Diabetes Care 30:343-347, 2007
-
(2007)
Diabetes Care
, vol.30
, pp. 343-347
-
-
Lee, J.1
Ma, S.2
Heng, D.3
Tan, C.E.4
Chew, S.K.5
Hughes, K.6
Tai, E.S.7
-
3
-
-
0019603446
-
The "metabolically-obese, " normal-weight individual
-
Ruderman NB, Schneider SH, Berchtold P: The "metabolically-obese, " normal-weight individual. Am J Clin Nutr 34:1617-1621, 1981
-
(1981)
Am J Clin Nutr
, vol.34
, pp. 1617-1621
-
-
Ruderman, N.B.1
Schneider, S.H.2
Berchtold, P.3
-
4
-
-
0031944785
-
The metabolically obese, normal-weight individual revisited
-
Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S: The metabolically obese, normal-weight individual revisited. Diabetes 47:699-713, 1998
-
(1998)
Diabetes
, vol.47
, pp. 699-713
-
-
Ruderman, N.1
Chisholm, D.2
Pi-Sunyer, X.3
Schneider, S.4
-
5
-
-
0024593457
-
Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance
-
Zavaroni I, Bonora E, Pagliara M, Dall'Aglio E, Luchetti L, Buonanno G, Bonati PA, Bergonzani M, Gnudi L, Passeri M, Reaven G: Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 320:702-706, 1989
-
(1989)
N Engl J Med
, vol.320
, pp. 702-706
-
-
Zavaroni, I.1
Bonora, E.2
Pagliara, M.3
Dall'Aglio, E.4
Luchetti, L.5
Buonanno, G.6
Bonati, P.A.7
Bergonzani, M.8
Gnudi, L.9
Passeri, M.10
Reaven, G.11
-
6
-
-
0026352764
-
Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent
-
Ferrari P, Weidmann P, Shaw S, Giachino D, Riesen W, Allemann Y, Heynen G: Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent. Am J Med 91:589-596, 1991
-
(1991)
Am J Med
, vol.91
, pp. 589-596
-
-
Ferrari, P.1
Weidmann, P.2
Shaw, S.3
Giachino, D.4
Riesen, W.5
Allemann, Y.6
Heynen, G.7
-
7
-
-
4444334616
-
Metabolic syndrome in normal-weight Americans: New definition of the metabolically obese, normal-weight individual
-
St-Onge MP, Janssen I, Heymsfield SB: Metabolic syndrome in normal-weight Americans: new definition of the metabolically obese, normal-weight individual. Diabetes Care 27:2222-2228, 2004
-
(2004)
Diabetes Care
, vol.27
, pp. 2222-2228
-
-
St-Onge, M.P.1
Janssen, I.2
Heymsfield, S.B.3
-
8
-
-
19744368235
-
Insulin resistance syndrome, body mass index and the risk of ischemic heart disease
-
St-Pierre AC, Cantin B, Mauriege P, Bergeron J, Dagenais GR, Despres JP, Lamarche B: Insulin resistance syndrome, body mass index and the risk of ischemic heart disease. CMAJ 172:1301-1305, 2005
-
(2005)
CMAJ
, vol.172
, pp. 1301-1305
-
-
St-Pierre, A.C.1
Cantin, B.2
Mauriege, P.3
Bergeron, J.4
Dagenais, G.R.5
Despres, J.P.6
Lamarche, B.7
-
9
-
-
0026356648
-
Insulin sensitivity, glucose effectiveness, and body fat distribution pattern in nondiabetic offspring of patients with NIDDM
-
Osei K, Cottrell DA, Orabella MM: Insulin sensitivity, glucose effectiveness, and body fat distribution pattern in nondiabetic offspring of patients with NIDDM. Diabetes Care 14:890-896, 1991
-
(1991)
Diabetes Care
, vol.14
, pp. 890-896
-
-
Osei, K.1
Cottrell, D.A.2
Orabella, M.M.3
-
10
-
-
0029874313
-
Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM
-
Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ: Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 45:633-638, 1996
-
(1996)
Diabetes
, vol.45
, pp. 633-638
-
-
Carey, D.G.1
Jenkins, A.B.2
Campbell, L.V.3
Freund, J.4
Chisholm, D.J.5
-
11
-
-
0023471966
-
Relation of body fat distribution to hyperinsulinemia in children and adolescents: The Bogalusa Heart Study
-
Freedman DS, Srinivasan SR, Burke GL, Shear CL, Smoak CG, Harsha DW, Webber LS, Berenson GS: Relation of body fat distribution to hyperinsulinemia in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr 46:403-410, 1987
-
(1987)
Am J Clin Nutr
, vol.46
, pp. 403-410
-
-
Freedman, D.S.1
Srinivasan, S.R.2
Burke, G.L.3
Shear, C.L.4
Smoak, C.G.5
Harsha, D.W.6
Webber, L.S.7
Berenson, G.S.8
-
12
-
-
0035191137
-
Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians
-
Raji A, Seely EW, Arky RA, Simonson DC: Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 86:5366-5371, 2001
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 5366-5371
-
-
Raji, A.1
Seely, E.W.2
Arky, R.A.3
Simonson, D.C.4
-
13
-
-
0043025606
-
Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance
-
Katsuki A, Sumida Y, Urakawa H, Gabazza EC, Murashima S, Maruyama N, Morioka K, Nakatani K, Yano Y, Adachi Y: Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance. Diabetes Care 26:2341-2344, 2003
-
(2003)
Diabetes Care
, vol.26
, pp. 2341-2344
-
-
Katsuki, A.1
Sumida, Y.2
Urakawa, H.3
Gabazza, E.C.4
Murashima, S.5
Maruyama, N.6
Morioka, K.7
Nakatani, K.8
Yano, Y.9
Adachi, Y.10
-
14
-
-
0029762156
-
Low insulin secretion and high fasting insulin and C-peptide levels predict increased visceral adiposity: 5-year follow-up among initially nondiabetic Japanese-American men
-
Boyko EJ, Leonetti DL, Bergstrom RW, Newell-Morris L, Fujimoto WY: Low insulin secretion and high fasting insulin and C-peptide levels predict increased visceral adiposity: 5-year follow-up among initially nondiabetic Japanese-American men. Diabetes 45:1010-1015, 1996
-
(1996)
Diabetes
, vol.45
, pp. 1010-1015
-
-
Boyko, E.J.1
Leonetti, D.L.2
Bergstrom, R.W.3
Newell-Morris, L.4
Fujimoto, W.Y.5
-
15
-
-
25644448096
-
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents
-
Petersen KF, Dufour S, Shulman GI: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med 2:e233, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Petersen, K.F.1
Dufour, S.2
Shulman, G.I.3
-
16
-
-
0032960890
-
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
-
Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU: Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119, 1999
-
(1999)
Diabetes
, vol.48
, pp. 1113-1119
-
-
Jacob, S.1
Machann, J.2
Rett, K.3
Brechtel, K.4
Volk, A.5
Renn, W.6
Maerker, E.7
Matthaei, S.8
Schick, F.9
Claussen, C.D.10
Haring, H.U.11
-
17
-
-
0036312905
-
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
-
Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, Yki-Jarvinen H: Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87:3023-3028, 2002
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3023-3028
-
-
Seppala-Lindroos, A.1
Vehkavaara, S.2
Hakkinen, A.M.3
Goto, T.4
Westerbacka, J.5
Sovijarvi, A.6
Halavaara, J.7
Yki-Jarvinen, H.8
-
18
-
-
0036828824
-
Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy
-
Gan SK, Samaras K, Thompson CH, Kraegen EW, Carr A, Cooper DA, Chisholm DJ: Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy. Diabetes 51:3163-3169, 2002
-
(2002)
Diabetes
, vol.51
, pp. 3163-3169
-
-
Gan, S.K.1
Samaras, K.2
Thompson, C.H.3
Kraegen, E.W.4
Carr, A.5
Cooper, D.A.6
Chisholm, D.J.7
-
19
-
-
0021268588
-
Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes
-
Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB: Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia 26:355-360, 1984
-
(1984)
Diabetologia
, vol.26
, pp. 355-360
-
-
Schneider, S.H.1
Amorosa, L.F.2
Khachadurian, A.K.3
Ruderman, N.B.4
-
20
-
-
0842328975
-
Reduced skeletal muscle oxygen uptake and reduced beta-cell function: Two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes
-
Thamer C, Stumvoll M, Niess A, Tschritter O, Haap M, Becker R, Shirkavand F, Bachmann O, Rett K, Volk A, Haring H, Fritsche A: Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes. Diabetes Care 26:2126-2132, 2003
-
(2003)
Diabetes Care
, vol.26
, pp. 2126-2132
-
-
Thamer, C.1
Stumvoll, M.2
Niess, A.3
Tschritter, O.4
Haap, M.5
Becker, R.6
Shirkavand, F.7
Bachmann, O.8
Rett, K.9
Volk, A.10
Haring, H.11
Fritsche, A.12
-
21
-
-
0029944207
-
Insulin resistance in relatives of NIDDM patients: The role of physical fitness and muscle metabolism
-
Nyholm B, Mengel A, Nielsen S, Skjaerbaek C, Moller N, Alberti KG, Schmitz O: Insulin resistance in relatives of NIDDM patients: the role of physical fitness and muscle metabolism. Diabetologia 39:813-822, 1996
-
(1996)
Diabetologia
, vol.39
, pp. 813-822
-
-
Nyholm, B.1
Mengel, A.2
Nielsen, S.3
Skjaerbaek, C.4
Moller, N.5
Alberti, K.G.6
Schmitz, O.7
-
22
-
-
33846691958
-
Androgens and diabetes in men: Results from the Third National Health and Nutrition Examination Survey (NHANES III)
-
Selvin E, Feinleib M, Zhang L, Rohrmann S, Rifai N, Nelson WG, Dobs A, Basaria S, Golden SH, Platz EA: Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care 30:234-238, 2007
-
(2007)
Diabetes Care
, vol.30
, pp. 234-238
-
-
Selvin, E.1
Feinleib, M.2
Zhang, L.3
Rohrmann, S.4
Rifai, N.5
Nelson, W.G.6
Dobs, A.7
Basaria, S.8
Golden, S.H.9
Platz, E.A.10
-
23
-
-
33644828241
-
Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
-
Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB: Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 91:843-850, 2006
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 843-850
-
-
Kupelian, V.1
Page, S.T.2
Araujo, A.B.3
Travison, T.G.4
Bremner, W.J.5
McKinlay, J.B.6
-
24
-
-
0023033340
-
A controlled randomized study on the effect of long-term physical exercise on the metabolic control in type 2 diabetic patients
-
Ronnemaa T, Mattila K, Lehtonen A, Kallio V: A controlled randomized study on the effect of long-term physical exercise on the metabolic control in type 2 diabetic patients. Acta Med Scand 220:219-224, 1986
-
(1986)
Acta Med Scand
, vol.220
, pp. 219-224
-
-
Ronnemaa, T.1
Mattila, K.2
Lehtonen, A.3
Kallio, V.4
-
25
-
-
0033582188
-
The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men
-
Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, Blair SN: The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 130:89-96, 1999
-
(1999)
Ann Intern Med
, vol.130
, pp. 89-96
-
-
Wei, M.1
Gibbons, L.W.2
Mitchell, T.L.3
Kampert, J.B.4
Lee, C.D.5
Blair, S.N.6
-
26
-
-
0036616180
-
The relation of body mass index, cardiorespiratory fitness, and all-cause mortality in women
-
Farrell SW, Braun L, Barlow CE, Cheng YJ, Blair SN: The relation of body mass index, cardiorespiratory fitness, and all-cause mortality in women. Obes Res 10:417-423, 2002
-
(2002)
Obes Res
, vol.10
, pp. 417-423
-
-
Farrell, S.W.1
Braun, L.2
Barlow, C.E.3
Cheng, Y.J.4
Blair, S.N.5
-
27
-
-
0034682052
-
Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes
-
Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN: Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med 132:605-611, 2000
-
(2000)
Ann Intern Med
, vol.132
, pp. 605-611
-
-
Wei, M.1
Gibbons, L.W.2
Kampert, J.B.3
Nichaman, M.Z.4
Blair, S.N.5
-
28
-
-
1042291857
-
Exercise capacity and body composition as predictors of mortality among men with diabetes
-
Church TS, Cheng YJ, Earnest CP, Barlow CE, Gibbons LW, Priest EL, Blair SN: Exercise capacity and body composition as predictors of mortality among men with diabetes. Diabetes Care 27:83-88, 2004
-
(2004)
Diabetes Care
, vol.27
, pp. 83-88
-
-
Church, T.S.1
Cheng, Y.J.2
Earnest, C.P.3
Barlow, C.E.4
Gibbons, L.W.5
Priest, E.L.6
Blair, S.N.7
-
29
-
-
0016571567
-
Effect of force-feeding upon basal insulin levels of rats
-
Bernstein IL, Lotter EC, Kulkosky PJ, Porte D Jr, Woods SC: Effect of force-feeding upon basal insulin levels of rats. Proc Soc Exp Biol Med 150:546-548, 1975
-
(1975)
Proc Soc Exp Biol Med
, vol.150
, pp. 546-548
-
-
Bernstein, I.L.1
Lotter, E.C.2
Kulkosky, P.J.3
Porte Jr, D.4
Woods, S.C.5
-
30
-
-
0027375768
-
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: Evidence for a hyperbolic function
-
Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, et al: Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42:1663-1672, 1993
-
(1993)
Diabetes
, vol.42
, pp. 1663-1672
-
-
Kahn, S.E.1
Prigeon, R.L.2
McCulloch, D.K.3
Boyko, E.J.4
Bergman, R.N.5
Schwartz, M.W.6
Neifing, J.L.7
Ward, W.K.8
Beard, J.C.9
Palmer, J.P.10
-
31
-
-
0017745414
-
Relationship between plasma and cerebrospinal fluid insulin levels of dogs
-
Woods SC, Porte D Jr: Relationship between plasma and cerebrospinal fluid insulin levels of dogs. Am J Physiol 233:E331-E334, 1977
-
(1977)
Am J Physiol
, vol.233
-
-
Woods, S.C.1
Porte Jr, D.2
-
32
-
-
0018621289
-
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
-
Woods SC, Lotter EC, McKay LD, Porte D Jr: Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282:503-505, 1979
-
(1979)
Nature
, vol.282
, pp. 503-505
-
-
Woods, S.C.1
Lotter, E.C.2
McKay, L.D.3
Porte Jr, D.4
-
33
-
-
0021433344
-
Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats
-
West DB, Fey D, Woods SC: Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 246:R776-R787, 1984
-
(1984)
Am J Physiol
, vol.246
-
-
West, D.B.1
Fey, D.2
Woods, S.C.3
-
34
-
-
0022500350
-
Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons
-
Figlewicz DP, Stein LJ, West D, Porte D Jr, Woods SC: Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons. Am J Physiol 250:R856-R860, 1986
-
(1986)
Am J Physiol
, vol.250
-
-
Figlewicz, D.P.1
Stein, L.J.2
West, D.3
Porte Jr, D.4
Woods, S.C.5
-
35
-
-
15444339427
-
Obesity, diabetes and the central nervous system
-
Porte D Jr, Seeley RJ, Woods SC, Baskin DG, Figlewicz DP, Schwartz MW: Obesity, diabetes and the central nervous system. Diabetologia 41:863-881, 1998
-
(1998)
Diabetologia
, vol.41
, pp. 863-881
-
-
Porte Jr, D.1
Seeley, R.J.2
Woods, S.C.3
Baskin, D.G.4
Figlewicz, D.P.5
Schwartz, M.W.6
-
36
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR: Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122-2125, 2000
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
Klein, R.7
Krone, W.8
Muller-Wieland, D.9
Kahn, C.R.10
-
37
-
-
0036267472
-
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
-
Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L: Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566-572, 2002
-
(2002)
Nat Neurosci
, vol.5
, pp. 566-572
-
-
Obici, S.1
Feng, Z.2
Karkanias, G.3
Baskin, D.G.4
Rossetti, L.5
-
38
-
-
0037315042
-
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
-
Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG Jr, Seeley RJ, Schwartz MW: Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52:227-231, 2003
-
(2003)
Diabetes
, vol.52
, pp. 227-231
-
-
Niswender, K.D.1
Morrison, C.D.2
Clegg, D.J.3
Olson, R.4
Baskin, D.G.5
Myers Jr, M.G.6
Seeley, R.J.7
Schwartz, M.W.8
-
39
-
-
0034699544
-
IRS-2 pathways integrate female reproduction and energy homeostasis
-
Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF: IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407:377-382, 2000
-
(2000)
Nature
, vol.407
, pp. 377-382
-
-
Burks, D.J.1
Font de Mora, J.2
Schubert, M.3
Withers, D.J.4
Myers, M.G.5
Towery, H.H.6
Altamuro, S.L.7
Flint, C.L.8
White, M.F.9
-
40
-
-
0037043534
-
Obesity: Keeping hunger at bay
-
Schwartz MW, Morton GJ: Obesity: keeping hunger at bay. Nature 418:595-597, 2002
-
(2002)
Nature
, vol.418
, pp. 595-597
-
-
Schwartz, M.W.1
Morton, G.J.2
-
41
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici S, Zhang BB, Karkanias G, Rossetti L: Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376-1382, 2002
-
(2002)
Nat Med
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
42
-
-
7044241101
-
Intranasal insulin reduces body fat in men but not in women
-
Hallschmid M, Benedict C, Schultes B, Fehm HL, Born J, Kern W: Intranasal insulin reduces body fat in men but not in women. Diabetes 53:3024-3029, 2004
-
(2004)
Diabetes
, vol.53
, pp. 3024-3029
-
-
Hallschmid, M.1
Benedict, C.2
Schultes, B.3
Fehm, H.L.4
Born, J.5
Kern, W.6
-
43
-
-
33746391488
-
A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes
-
Hermansen K, Davies M, Derezinski T, Martinez Ravn G, Clauson P, Home P: A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 29:1269-1274, 2006
-
(2006)
Diabetes Care
, vol.29
, pp. 1269-1274
-
-
Hermansen, K.1
Davies, M.2
Derezinski, T.3
Martinez Ravn, G.4
Clauson, P.5
Home, P.6
-
44
-
-
33646530498
-
Tissue selectivity of insulin detemir action in vivo
-
Hennige AM, Sartorius T, Tschritter O, Preissl H, Fritsche A, Ruth P, Haring HU: Tissue selectivity of insulin detemir action in vivo. Diabetologia 49:1274-1282, 2006
-
(2006)
Diabetologia
, vol.49
, pp. 1274-1282
-
-
Hennige, A.M.1
Sartorius, T.2
Tschritter, O.3
Preissl, H.4
Fritsche, A.5
Ruth, P.6
Haring, H.U.7
-
45
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91, 1993
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
46
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS: Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389:610-614, 1997
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
47
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
Aguirre V, Uchida T, Yenush L, Davis R, White MF: The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
48
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE: Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293:1673-1677, 2001
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
49
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS: A central role for JNK in obesity and insulin resistance. Nature 420:333-336, 2002
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
50
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS: Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A 103:10741-10746, 2006
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 10741-10746
-
-
Tuncman, G.1
Hirosumi, J.2
Solinas, G.3
Chang, L.4
Karin, M.5
Hotamisligil, G.S.6
-
51
-
-
0034104298
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
-
Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, Hani EH, Vionnet N, Nicod P, Boutin P, Froguel P: The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat Genet 24:291-295, 2000
-
(2000)
Nat Genet
, vol.24
, pp. 291-295
-
-
Waeber, G.1
Delplanque, J.2
Bonny, C.3
Mooser, V.4
Steinmann, M.5
Widmann, C.6
Maillard, A.7
Miklossy, J.8
Dina, C.9
Hani, E.H.10
Vionnet, N.11
Nicod, P.12
Boutin, P.13
Froguel, P.14
-
52
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW: SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A 98:13681-13686, 2001
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
Leisten, J.C.7
Motiwala, A.8
Pierce, S.9
Satoh, Y.10
Bhagwat, S.S.11
Manning, A.M.12
Anderson, D.W.13
-
53
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461, 2004
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
54
-
-
0034613375
-
Function of GATA transcription factors in preadipocyte-adipocyte transition
-
Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS: Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290:134-138, 2000
-
(2000)
Science
, vol.290
, pp. 134-138
-
-
Tong, Q.1
Dalgin, G.2
Xu, H.3
Ting, C.N.4
Leiden, J.M.5
Hotamisligil, G.S.6
-
55
-
-
34247511496
-
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis
-
Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS: Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 129:537-548, 2007
-
(2007)
Cell
, vol.129
, pp. 537-548
-
-
Wellen, K.E.1
Fucho, R.2
Gregor, M.F.3
Furuhashi, M.4
Morgan, C.5
Lindstad, T.6
Vaillancourt, E.7
Gorgun, C.Z.8
Saatcioglu, F.9
Hotamisligil, G.S.10
-
56
-
-
0025292829
-
The response to long-term overfeeding in identical twins
-
Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, Dussault J, Moorjani S, Pinault S, Fournier G: The response to long-term overfeeding in identical twins. N Engl J Med 322:1477-1482, 1990
-
(1990)
N Engl J Med
, vol.322
, pp. 1477-1482
-
-
Bouchard, C.1
Tremblay, A.2
Despres, J.P.3
Nadeau, A.4
Lupien, P.J.5
Theriault, G.6
Dussault, J.7
Moorjani, S.8
Pinault, S.9
Fournier, G.10
-
57
-
-
0032588152
-
Familial aggregation of VO(2max) response to exercise training: Results from the HERITAGE Family Study
-
Bouchard C, An P, Rice T, Skinner JS, Wilmore JH, Gagnon J, Perusse L, Leon AS, Rao DC: Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study. J Appl Physiol 87:1003-1008, 1999
-
(1999)
J Appl Physiol
, vol.87
, pp. 1003-1008
-
-
Bouchard, C.1
An, P.2
Rice, T.3
Skinner, J.S.4
Wilmore, J.H.5
Gagnon, J.6
Perusse, L.7
Leon, A.S.8
Rao, D.C.9
-
58
-
-
0033866536
-
AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study
-
Rankinen T, Gagnon J, Perusse L, Chagnon YC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C: AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study. Am J Physiol Heart Circ Physiol 279:H368-H374, 2000
-
(2000)
Am J Physiol Heart Circ Physiol
, vol.279
-
-
Rankinen, T.1
Gagnon, J.2
Perusse, L.3
Chagnon, Y.C.4
Rice, T.5
Leon, A.S.6
Skinner, J.S.7
Wilmore, J.H.8
Rao, D.C.9
Bouchard, C.10
-
59
-
-
0142020833
-
Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration
-
Hildebrandt AL, Pilegaard H, Neufer PD: Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration. Am J Physiol Endocrinol Metab 285:E1021-E1027, 2003
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Hildebrandt, A.L.1
Pilegaard, H.2
Neufer, P.D.3
-
60
-
-
0035003124
-
Individual differences in response to regular physical activity
-
Bouchard C, Rankinen T: Individual differences in response to regular physical activity. Med Sci Sports Exerc 33 (6 Suppl.):S446 -S451, 2001
-
(2001)
Med Sci Sports Exerc
, vol.33
, Issue.6 SUPPL.
-
-
Bouchard, C.1
Rankinen, T.2
-
61
-
-
0033550795
-
Beta2-adrenoceptor gene polymorphism, body weight, and physical activity
-
Meirhaeghe A, Helbecque N, Cottel D, Amouyel P: Beta2-adrenoceptor gene polymorphism, body weight, and physical activity. Lancet 353:896, 1999
-
(1999)
Lancet
, vol.353
, pp. 896
-
-
Meirhaeghe, A.1
Helbecque, N.2
Cottel, D.3
Amouyel, P.4
-
62
-
-
0042666793
-
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2
-
Reynisdottir I, Thorleifsson G, Benediktsson R, Sigurdsson G, Emilsson V, Einarsdottir AS, Hjorleifsdottir EE, Orlygsdottir GT, Bjornsdottir GT, Saemundsdottir J, Halldorsson S, Hrafnkelsdottir S, Sigurjonsdottir SB, Steinsdottir S, Martin M, Kochan JP, Rhees BK, Grant SF, Frigge ML, Kong A, Gudnason V, Stefansson K, Gulcher JR: Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am J Hum Genet 73:323-335, 2003
-
(2003)
Am J Hum Genet
, vol.73
, pp. 323-335
-
-
Reynisdottir, I.1
Thorleifsson, G.2
Benediktsson, R.3
Sigurdsson, G.4
Emilsson, V.5
Einarsdottir, A.S.6
Hjorleifsdottir, E.E.7
Orlygsdottir, G.T.8
Bjornsdottir, G.T.9
Saemundsdottir, J.10
Halldorsson, S.11
Hrafnkelsdottir, S.12
Sigurjonsdottir, S.B.13
Steinsdottir, S.14
Martin, M.15
Kochan, J.P.16
Rhees, B.K.17
Grant, S.F.18
Frigge, M.L.19
Kong, A.20
Gudnason, V.21
Stefansson, K.22
Gulcher, J.R.23
more..
-
63
-
-
32544451924
-
-
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320 -323, 2006
-
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320 -323, 2006
-
-
-
-
64
-
-
0031848068
-
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
-
Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ, Clevers H: Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19:379 -383, 1998
-
(1998)
Nat Genet
, vol.19
, pp. 379-383
-
-
Korinek, V.1
Barker, N.2
Moerer, P.3
van Donselaar, E.4
Huls, G.5
Peters, P.J.6
Clevers, H.7
-
65
-
-
33644618433
-
The biology of incretin hormones
-
Drucker DJ: The biology of incretin hormones. Cell Metab 3:153-165, 2006
-
(2006)
Cell Metab
, vol.3
, pp. 153-165
-
-
Drucker, D.J.1
-
66
-
-
34547702501
-
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
-
Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjogren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155-2163, 2007
-
(2007)
J Clin Invest
, vol.117
, pp. 2155-2163
-
-
Lyssenko, V.1
Lupi, R.2
Marchetti, P.3
Del Guerra, S.4
Orho-Melander, M.5
Almgren, P.6
Sjogren, M.7
Ling, C.8
Eriksson, K.F.9
Lethagen, A.L.10
Mancarella, R.11
Berglund, G.12
Tuomi, T.13
Nilsson, P.14
Del Prato, S.15
Groop, L.16
-
67
-
-
0037034257
-
Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
Fowler, S.E.3
Hamman, R.F.4
Lachin, J.M.5
Walker, E.A.6
Nathan, D.M.7
-
68
-
-
33746075560
-
Diabetes Prevention Program Research Group: TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
-
Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D, Diabetes Prevention Program Research Group: TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241-250, 2006
-
(2006)
N Engl J Med
, vol.355
, pp. 241-250
-
-
Florez, J.C.1
Jablonski, K.A.2
Bayley, N.3
Pollin, T.I.4
de Bakker, P.I.5
Shuldiner, A.R.6
Knowler, W.C.7
Nathan, D.M.8
Altshuler, D.9
-
69
-
-
34250655269
-
The new type 2 diabetes gene TCF7L2
-
Florez JC: The new type 2 diabetes gene TCF7L2. Curr Opin Clin Nutr Metab Care 10:391-396, 2007
-
(2007)
Curr Opin Clin Nutr Metab Care
, vol.10
, pp. 391-396
-
-
Florez, J.C.1
-
70
-
-
34347393853
-
TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population
-
Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ: TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population. Diabetes 56:1943-1947, 2007
-
(2007)
Diabetes
, vol.56
, pp. 1943-1947
-
-
Loos, R.J.1
Franks, P.W.2
Francis, R.W.3
Barroso, I.4
Gribble, F.M.5
Savage, D.B.6
Ong, K.K.7
O'Rahilly, S.8
Wareham, N.J.9
|